Electrodes/paper sandwich devices for in situ sensing of hydrogen peroxide secretion from cells growing in gels-in-paper 3-dimensional matrix

Shi, Zhuanzhuan; Wu, Xiaoshuai; Gao, Lixia; Tian, YunLi; Yu, Ling

doi:10.1039/c4ay00695j

Cited by 23 publications

(22 citation statements)

References 54 publications

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“…Primary and secondary antibodies of CEA and AFP were deposited on the sensor platform and 3D‐rGO@redox probes amplifiers, respectively. A disposable carbon paper electrode (CPE)/cells‐in‐paper/CPE sandwich device was developed by Shi et al for the in situ detection of extracellular hydrogen peroxide produced from cells growing in the paper matrix. CPEs were functionalized by a CNT/rGO/MnO 2 aerogel nanocomposite prepared by freeze‐drying from the corresponding hydrogel due to the intimate contact of the sandwiched paper with the electrodes.…”

Section: Graphene Assemblies For Biosensorsmentioning

confidence: 99%

Recent Advances in Sensing Applications of Graphene Assemblies and Their Composites

Tùng

Nine

Krebsz

et al. 2017

Adv Funct Materials

240

139

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Development of next-generation sensor devices is gaining tremendous attention in both academia and industry because of their broad applications in manufacturing processes, food and environment control, medicine, disease diagnostics, security and defense, aerospace, and so forth. Current challenges include the development of low-cost, ultrahigh, and user-friendly sensors, which have high selectivity, fast response and recovery times, and small dimensions. The critical demands of these new sensors are typically associated with advanced nanoscale sensing materials. Among them, graphene and its derivatives have demonstrated the ideal properties to overcome these challenges and have merged as one of the most popular sensing platforms for diverse applications. A broad range of graphene assemblies with different architectures, morphologies, and scales (from nano-, micro-, to macrosize) have been explored in recent years for designing new high-performing sensing devices. Herein, this study presents and discusses recent advances in synthesis strategies of assembled graphene-based superstructures of 1D, 2D, and 3D macroscopic shapes in the forms of fibers, thin films, and foams/aerogels. The fabricated state-of-the-art applications of these materials in gas and vapor, biomedical, piezoresistive strain and pressure, heavy metal ion, and temperature sensors are also systematically reviewed and discussed, and their sensing performance is compared.

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Section: Graphene Assemblies For Biosensorsmentioning

confidence: 99%

Recent Advances in Sensing Applications of Graphene Assemblies and Their Composites

Tùng

Nine

Krebsz

et al. 2017

Adv Funct Materials

240

139

View full text Add to dashboard Cite

show abstract

“…To prepare the lightweight sensors, decorating paper with conductive CNT/graphene/MnO 2 aerogel formed disposable biosensors for biology studies. [151] But as most 3D catalysts, additional reference electrode and counter electrode is required. Hamed et al inkjet-printed paper with multi-walled carbon nanotube for conductive paper and then casted Ag nanoparticles electrocatalyst on the MWCNT electrode surface, which can form H 2 O 2 sensor with single working electrode and be modified with different catalysts to achieve multi-electrode for multi-channel detection (Figure 4).…”

Section: Unconventional Substrates For Free-standing 3d Electrodesmentioning

confidence: 99%

Free‐Standing 3D Electrodes for Electrochemical Detection of Hydrogen Peroxide

et al. 2019

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Electrochemical detection of hydrogen peroxide has achieved rapid development, due to the wide presence in industrial production, everyday life, bioprocess and green energy chemistry, etc. Many three‐dimensional structures have emerged as state‐of‐the‐art electrocatalysts due to their fascinating structures and electrochemical properties. This review summarizes free‐standing three‐dimensional electrocatalysts based on metal, metal oxide, carbon & silicon, and unconventional materials for detection of hydrogen peroxide with low limit of detection, wide range and fast response. The work also highlights their applications in near neutral conditions, especially their ability for single cell detection and mapping in biological environment. Further exploration into these materials together with devices design will facilitate the development of next‐generation detection technologies toward in situ and real‐time detection and contribute to wearable/portable smart detection electronics.

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“…printed a working electrode mixed with cobalt(II) phthalocyanine (CoPC) to electrocatalytically detect thiols . Other examples have modified screen‐printed carbon electrodes (SPCE) with nanoparticles (NPs) or graphene to improve performance .…”

Section: Epad Fabricationmentioning

confidence: 99%

Electrochemical paper‐based microfluidic devices

2015

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Self-pumping porous microfluidic devices have attracted significant interest because of their low cost and broad applicability in point-of-care and low resource settings. One limitation of many of the devices is sensitivity and selectivity for detection. Electrochemistry can provide a sensitive, selective detection method while still using low cost, portable instrumentation as typified by handheld glucometers. Here, the development of electrochemical paper-based analytical devices (ePADs) is reviewed. Given the importance of electrode geometry and composition, fabrication methods are reviewed first. This is followed by a review of example applications demonstrated for ePADs. Finally, major accomplishments and future directions are summarized.

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Electrodes/paper sandwich devices for in situ sensing of hydrogen peroxide secretion from cells growing in gels-in-paper 3-dimensional matrix

Abstract: The CNT/graphene/MnO2 aerogel decorated electrode/paper sandwich device can in situ sense hydrogen peroxide released from cells growing in a 3-dimensional paper matrix, offering new insights on designing of disposable biosensors for cell biology studies.

Cited by 23 publications

References 54 publications

Recent Advances in Sensing Applications of Graphene Assemblies and Their Composites

Recent Advances in Sensing Applications of Graphene Assemblies and Their Composites

Free‐Standing 3D Electrodes for Electrochemical Detection of Hydrogen Peroxide

Electrochemical paper‐based microfluidic devices

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