Electrospun nanofibrous polymeric scaffold with targeted drug release profiles for potential application as wound dressing

Thakur, Rashmi; Florek, Charles A.; Kohn, Joachim; Michniak, B. B.

doi:10.1016/j.ijpharm.2008.07.033

Cited by 286 publications

(174 citation statements)

References 32 publications

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“…For instance, bioactive agents can be incorporated in the matrix or encapsulated into hollow nanofibres [114]. When the bioactive agent is incorporated in the matrix, there is a strong burst release within the first few hours [115]. Therefore, when the bioactive agent is encapsulated into hollow nanofibres, there is a better control of the bioactive agent release profile, but some of the complications during nanofibre preparation do not allow for easy large-scale production [116].…”

Section: Combining Liposomes With Scaffoldsmentioning

confidence: 99%

Liposomes in tissue engineering and regenerative medicine

Monteiro

Martins

Reis

et al. 2014

J. R. Soc. Interface.

329

217

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Liposomes are vesicular structures made of lipids that are formed in aqueous solutions. Structurally, they resemble the lipid membrane of living cells. Therefore, they have been widely investigated, since the 1960s, as models to study the cell membrane, and as carriers for protection and/or delivery of bioactive agents. They have been used in different areas of research including vaccines, imaging, applications in cosmetics and tissue engineering. Tissue engineering is defined as a strategy for promoting the regeneration of tissues for the human body. This strategy may involve the coordinated application of defined cell types with structured biomaterial scaffolds to produce living structures. To create a new tissue, based on this strategy, a controlled stimulation of cultured cells is needed, through a systematic combination of bioactive agents and mechanical signals. In this review, we highlight the potential role of liposomes as a platform for the sustained and local delivery of bioactive agents for tissue engineering and regenerative medicine approaches.

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Section: Combining Liposomes With Scaffoldsmentioning

confidence: 99%

Liposomes in tissue engineering and regenerative medicine

Monteiro

Martins

Reis

et al. 2014

J. R. Soc. Interface.

329

217

View full text Add to dashboard Cite

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“…For example, the crystallinity of the polymer controls the rate of drug release as semi-crystalline polymers showed in general a higher extent of burst because of two reasons: on one hand, the instantaneous release of the drug deposited at the fiber surface, and on the other hand, the hindered release of the drug from the fiber bulk due to limited water uptake in the semi-crsytalline regions [20]. The drug state in the fibers is also an important factor since it was shown that a drug that is incorporated in crystalline form will mainly be deposited outside the fibers and trigger burst release, while drug in amorphous state will be loaded inside the fibers and be released in a sustained manner [22,23,27]. Drug loading is another factor that can affect the drug release: higher loadings will produce faster release ( [18,21,22]); on one hand, at high loadings, there is more surface segregated drug that dissolves fast and on the other hand, there is an increase in porosity during drug elution proportional to the initial amount of drug [18].…”

Section: Introductionmentioning

confidence: 99%

Effects of drug solubility, state and loading on controlled release in bicomponent electrospun fibers

Natu

Sousa

Gil

2010

International Journal of Pharmaceutics

148

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Bicomponent fibers of two semi-crystalline (co)polymers, poly(ε-caprolactone), PCL and poly(oxyethylene-b-oxypropylene-b-oxyethylene), Lu were obtained by electrospinning. Acetazolamide and timolol maleate were loaded in the fibers in different concentrations (below and above the drug solubility limit in polymer) in order to determine the effect of drug solubility in polymer, drug state, drug loading and fiber composition on fiber morphology, drug distribution and release kinetics. The high loadings fibers (with drug in crystalline form) showed higher burst and faster release than low drug content fibers, indicating the release was more sustained when the drug was encapsulated inside the fibers, in amorphous form. Moreover, timolol maleate was released faster than acetazolamide, indicating that drug solubility in polymer influences the partition of drug between polymer and elution medium, while fiber composition also controlled drug release. At low loadings, total release was not achieved (cumulative release percentages smaller than 100 %), suggesting that drug remained trapped in the fibers. The modeling of release data implied a three stage release mechanism: a dissolution stage, a desorption and subsequent diffusion through water filled pores, followed by polymer degradation control.

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“…10 In addition, nanofibers have been proven effective in treating wounds by irrigation with anesthetic solution, followed by the application of prophylactic antibiotics to prevent wound infection. 11 However, the successful incorporation of drugs with distinct properties, such as solubility, in nanofibers generally requires the use of multiple carriers or solvents, limiting the likelihood of simultaneous delivery. 10 Furthermore, it is a great challenge to achieve controlled release of each drug in an intermittent and sequential manner.…”

Section: Introductionmentioning

confidence: 99%

Electrospun composite nanofibers containing nanoparticles for the programmable release of dual drugs

Wang

Qiao

Wang

et al. 2011

Polym J

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In this study, electrospun composite nanofibers containing nanoparticles for the programmable release of dual drugs were successfully fabricated through a one-step, single-nozzle electrospinning technique. Field-emission scanning electron microscopy and scanning electron microscopy were used to examine the morphology of the nanoparticles and electrospun nanofibers, respectively. The distribution of nanoparticles in the composite nanofibers was evaluated by fluorescence microscopy and laser scanning confocal microscopy. The results indicate that the nanoparticles were encapsulated within the composite nanofibers, forming a core-sheath structure. The different release behaviors of the drugs were ascribed to their varying distribution in the nanofibers and their interaction with carriers. A programmable release of both drugs was also achieved by adjusting the preparation process of the electrospinning solution. Composite nanofibers that can provide a platform for dual-drug loading and the programmed release of each drug may find application in drug delivery systems or in the tissue-engineering field.

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Electrospun nanofibrous polymeric scaffold with targeted drug release profiles for potential application as wound dressing

Cited by 286 publications

References 32 publications

Liposomes in tissue engineering and regenerative medicine

Liposomes in tissue engineering and regenerative medicine

Effects of drug solubility, state and loading on controlled release in bicomponent electrospun fibers

Electrospun composite nanofibers containing nanoparticles for the programmable release of dual drugs

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