2005
DOI: 10.1016/j.jsgi.2005.02.008
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Establishment and Characterization of a Human First-Trimester Extravillous Trophoblast Cell Line (TEV-1)

Abstract: Phenotypic and biologic characteristics of TEV-1 were shown as the properties of extravillous trophoblasts; thus, the TEV-1 cell line may be used as a cell model in extravillous trophoblast studies.

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Cited by 60 publications
(40 citation statements)
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“…[12][13][14] While cell lines provide a convenient, high-throughput tool to study trophoblast migration, they exhibit some important differences from primary EVTs, meaning that caution needs to be exercised in interpreting the results of these studies. For example, choriocarcinoma derived cell lines are characterized by their transformation from normal EVTs to highly invasive cancerous cells with extensive abnormalities in chromosome number (>70) and rearrangement.…”
Section: Cell Linesmentioning
confidence: 99%
“…[12][13][14] While cell lines provide a convenient, high-throughput tool to study trophoblast migration, they exhibit some important differences from primary EVTs, meaning that caution needs to be exercised in interpreting the results of these studies. For example, choriocarcinoma derived cell lines are characterized by their transformation from normal EVTs to highly invasive cancerous cells with extensive abnormalities in chromosome number (>70) and rearrangement.…”
Section: Cell Linesmentioning
confidence: 99%
“…The normal trophoblast cell line, TEV1, was previously established and characterized in our center. 20 All cells were grown in Minimum Essential Medium Eagle (Sigma St. Louis, MO) supplemented with 10% fetal bovine serum (JRH Biosciences, Lenexa, KS) and 100 U/ml penicillin and streptomycin (Invitrogen, San Diego, CA).…”
Section: Cell Linesmentioning
confidence: 99%
“…21,23 Briefly, 5 m formalin-fixed paraffin sections were cut, deparaffinized and stained with antibodies against PAK1 and p-PAK2 Ser 20 (as listed in Table 2) using UltraVision LPValue Detection System (Lab Vision Corporation, Fremont, CA). These antibodies were known to cross-react with the corresponding target proteins in humans as indicated by the manufacturers and were used in our previous study.…”
Section: Immunohistochemical Stainingmentioning
confidence: 99%
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