Establishment and ultrasound characteristics of atherosclerosis in rhesus monkey

Zeng, Wen; Wen, Xiaorong; Gong, Li; Sun, Jiayu; Yang, Jing; Liao, Jiali; Qian, Can; Chen, Wei; Song, Bin

doi:10.1186/1475-925x-14-s1-s13

Cited by 6 publications

(8 citation statements)

References 24 publications

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“…Our present study proved that 1-year feeding with IPB-1 diet increases the presence of plaque (by USG), in which the prevalence of plaques in the left arteries was higher than the right arteries in both common carotid and carotid BIF. These results differ from those reported in rhesus macaques that high-fat diet-induced plaques are more worse in the right carotid arteries [32].…”

Section: Discussioncontrasting

confidence: 99%

Metabolic and morphometric changes in Indonesian cynomolgus monkeys (Macaca fascicularis) fed an atherogenic diet composed of locally sourced ingredients

et al. 2018

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Background and Aim:This study was designed to determine the effects of a new atherogenic diet formulated at Institut Pertanian Bogor (IPB) (Bogor, Indonesia) on metabolic, morphometric, and carotid artery imaging of cynomolgus monkeys.Materials and Methods:A total of 20 adult male cynomolgus monkeys fed IPB-1 atherogenic diet for 1 year. Total plasma cholesterol (TPC), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, and morphometric measurements were evaluated at baseline and monthly during the study. Carotid plaques and intima-media thickness (IMT) were measured using ultrasonography at baseline and after 8 months of treatment.Results:This diet increased TPC, LDL, and TPC/HDL ratio and induced carotid atherosclerosis in this model. The TPC, LDL, and TPC/HDL ratio were positively associated; however, HDL was negatively associated with carotid plaques and IMT.Conclusion:The IPB-1 atherogenic diet formulated with locally and readily available ingredients provides an economically and scientifically feasible monkey model to study atherosclerosis in Indonesia and Southeast Asia.

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Section: Discussioncontrasting

confidence: 99%

Metabolic and morphometric changes in Indonesian cynomolgus monkeys (Macaca fascicularis) fed an atherogenic diet composed of locally sourced ingredients

et al. 2018

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“…FPG, 2hPPG, HbA1c and lipid parameters were measured as we previously performed [ 23 , 26 ]. Body mass index (BMI) was calculated using body weight divided by the square of CRL.…”

Section: Methodsmentioning

confidence: 99%

Diastolic dysfunction in spontaneous type 2 diabetes rhesus monkeys: a study using echocardiography and magnetic resonance imaging

Qian¹,

Gong²,

Yang³

et al. 2015

BMC Cardiovasc Disord

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BackgroundDiastolic heart failure is a common and deadly complication of diabetes mellitus, with the development of diabetic cardiomyopathy as one of the key determinants of the disease’s complex pathology. The cause of the association is unknown and has no approved therapy strategies as of yet. However significant advances in this area may come from studies on suitable animal models.MethodsA total of 25 male rhesus monkeys (12-16 years, 9-13 kg) were enrolled. Fifteen of them were diagnosed as spontaneous type 2 diabetes mellitus (T2DM, FPG ≥ 104 mg/dl, HbA1c: 4.7-5.5 %, diabetes duration: 1-4 years). The other 10 monkeys were non-diabetic (ND, FPG < 90 mg/dl). Echocardiography and cardiac magnetic resonance were used for evaluating the cardiac structure and function. One T2DM monkey with impaired diastolic function and another ND monkey were both sacrificed to gain the necessary pathology and protein expression studies displayed here.ResultsSix out of 15 T2DM rhesus monkeys were diagnosed with diastolic dysfunction (DD) by echocardiography. Additionally, no abnormalities were found in the group which we determined as the ND monkeys. The six DD monkeys all showed low e’ velocity and decreased e’/a’ ratio, among which three of them showing decreased E/A ratio and the other 3 having elevated E/A ratio, this appears to be similar to the impaired relaxation pattern and pseudonormal pattern found in human patients respectively. The EF and FS of monkeys with pseudonormal pattern decreased significantly compared with ND subjects. A CMR study showed that LVID at end systole of 5 DD monkeys is significantly longer than that of 3 ND monkeys. Of great interest, myocardium lesions and mitochondria impairments and increased expression of AGEs and caspase-3 were found in a sacrificed DD subject.ConclusionThe changes in the imaging and physiological markers of spontaneous T2DM rhesus monkeys are similar to those key markers found in human type 2 diabetes and diastolic dysfunction. This monkey model could help the medical community and us to understand the pathology of this debilitating disease and serve as a beginning to explore important measures to prevent and treat diabetic cardiomyopathy.

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“…3 In addition, it was previously reported that fasting could affect the serum biochemistry profile of apparently healthy male and female cynomolgus monkeys, but its effect was not evaluated in this study. 17 The rescued LTM in this study were not…”

Section: Discussionmentioning

confidence: 64%

Correlations of serum biochemistry profile with ultrasonic histogram of liver, gallbladder, and kidneys and morphometry of rescued long‐tailed macaques (Macaca fascicularis)

Cardenio

Acorda

Lastica-Ternura

2020

J of Medical Primatology

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Diagnostic tools are infrequently used in assessing health conditions of rescued wildlife such as the long-tailed macaques in local wildlife rehabilitation and rescue centers in the Philippines. Health assessment of recently surrendered and rescued long-tailed macaques is limited to physical examination. Diagnostic tools such as serum biochemistry and diagnostic imaging are not readily present and performed upon arrival of new monkeys and during regular general health checkup of long-tailed macaques. These diagnostic tools are important in evaluating the general health condition of the animal, disease diagnosis, and monitoring. Serum evaluation is infrequently performed in rescued monkeys and is limited only to those being kept in laboratories. Serum biochemistry values for laboratory-kept long-tailed macaques originated from Mauritius, 1 China, 2 and Cambodia 3 were previously reported. Sex-related differences were observed on serum biochemistry values of healthy male and female macaques in previous studies. 4-8 The differences in serum biochemistry values observed in monkeys from a different country of origin might have been caused by their exposure to different dietary constituents and environment. Moreover, many factors including climate, genetic background, and age of the animals could affect the results. 4 In addition, increase or

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Establishment and ultrasound characteristics of atherosclerosis in rhesus monkey

Cited by 6 publications

References 24 publications

Metabolic and morphometric changes in Indonesian cynomolgus monkeys (Macaca fascicularis) fed an atherogenic diet composed of locally sourced ingredients

Metabolic and morphometric changes in Indonesian cynomolgus monkeys (Macaca fascicularis) fed an atherogenic diet composed of locally sourced ingredients

Diastolic dysfunction in spontaneous type 2 diabetes rhesus monkeys: a study using echocardiography and magnetic resonance imaging

Correlations of serum biochemistry profile with ultrasonic histogram of liver, gallbladder, and kidneys and morphometry of rescued long‐tailed macaques (Macaca fascicularis)

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