Estudio de enfermedad celíaca en pacientes con enfermedad por hígado graso no alcohólico y con hepatopatías autoinmunes

Valera, José Miguel; Hurtado, Carmen; Poníachik, Jaime; Abumohor, P; Brahm, Javier

doi:10.1157/13114565

Cited by 4 publications

(5 citation statements)

References 25 publications

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“…Out of these, 15 articles were deemed relevant, and 8 of these had required biopsy with villous atrophy (Marsh III) for the celiac diagnosis, thus included in the main analysis. The reasons for excluding 16 papers were: data only from correspondence/letter to editor (n = 2), 20,21 conference abstract (n = 3), 22‐24 poster presentation (n = 2), 25,26 review article (n = 2), 27,28 meta‐analysis per se (n = 1), 29 insufficient/incorrect data (n = 5) and 30‐34 non‐English (n = 1) 35 . The selection process is illustrated in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…The reasons for excluding 16 papers were: data only from correspondence/letter to editor (n = 2), 20,21 conference abstract (n = 3), [22][23][24] poster presentation (n = 2), 25,26 review article (n = 2), 27,28 metaanalysis per se (n = 1), 29 insufficient/incorrect data (n = 5) and [30][31][32][33][34] non-English (n = 1). 35 The selection process is illustrated in…”

Section: Re Sultsmentioning

confidence: 99%

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High prevalence of celiac disease in autoimmune hepatitis: Systematic review and meta‐analysis

Haggård

Glimberg

Lebwohl

et al. 2021

Liver International

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Background Previous studies investigating the prevalence of celiac disease (CD) in individuals with autoimmune hepatitis (AIH) have shown highly variable results. We therefore aimed to examine the prevalence of CD in individuals with AIH. Methods Two professional librarians searched PubMed, EMBASE, Cochrane and Web of Science Core Collection up until 7 February 2020. The search terms included ‘celiac disease’, ‘celiac’, ‘transglutaminases’, ‘gluten’, ‘gliadin’, ‘EMA’, ‘TTG’ and ‘villous’ combined with ‘autoimmune’, ‘hepatitis’, ‘ANA’, ‘SMA’ and ‘LKM’. This search yielded 2419 unique publications. A systematic review based on the PRISMA guidelines resulted in 31 articles eligible for full text review. Fifteen articles were deemed relevant, with 8 being included in our main analysis. A fixed‐effect inverse variance‐weighted model was used, and heterogeneity was calculated. Results Our main analysis included 567 individuals with AIH from eight studies, where biopsy‐verified CD (equivalent to Marsh III) was seen in 23 individuals (4.1%). The pooled prevalence of CD in AIH was 3.5% (95% CI = 1.6%‐5.3%) (heterogeneity: P = .874; I2 = 0.0%), which is clearly higher than the 1% CD seen in most general populations. When also including studies where CD had been diagnosed through positive serology without biopsy (15 studies: n = 1817 individuals with AIH), the pooled prevalence of CD was 2.9% (95% CI = 2.1%‐3.8%) (heterogeneity: P < .001; I2 = 66.8%). Conclusion Our results demonstrate a higher prevalence of CD in individuals with AIH compared to the general population. CD screening may be considered in patients with AIH.

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Section: Resultsmentioning

confidence: 99%

Section: Re Sultsmentioning

confidence: 99%

High prevalence of celiac disease in autoimmune hepatitis: Systematic review and meta‐analysis

Haggård

Glimberg

Lebwohl

et al. 2021

Liver International

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“…Celiac disease has been reported in 4%–13% of cases with NASH [39–41]. The etiopathogenesis of hepatic steatosis in CD is uncertain.…”

Section: Hepatobiliary Disordersmentioning

confidence: 99%

Hepatobiliary Disorders in Celiac Disease: An Update

Prasad

Debi

Sinha

et al. 2011

International Journal of Hepatology

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This communication reviews recent literature and summarizes hepatobiliary abnormalities that may complicate the clinical course of celiac disease. A wide spectrum of hepatobiliary diseases has been described, including asymptomatic elevations of liver enzyme levels, nonspecific hepatitis, nonalcoholic fatty liver disease, and autoimmune and cholestatic liver disease. Moreover, in the majority of patients, liver enzyme levels will normalize on a gluten-free diet. In addition, celiac disease may be associated with rare hepatic complications, such as hepatic T-cell lymphoma. Because many celiac patients do not have overt gastrointestinal symptoms, a high index of suspicion is required. Simple methods of detecting celiac disease such as serum antibody tests help in the early identification of the disease, thus preventing serious complications of the disorder. The IgG DGP antibody test and IgA tTG antibody test used in combination are an excellent screening test for suspected cases of celiac disease.

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“…Anti-tTG antibodies are frequently elevated in autoimmune hepatitis patients [140,141], particularly in those with a HLA-DQ2 or -DQ8 background. It is shown, however, that these antibodies regress after liver transplantation without gluten exclusion and many such patients do not have intestinal pathology [140].…”

Section: Autoimmune Diseases Associated With Csmentioning

confidence: 99%

“…On the other hand, the specificity of anti-endomysial antibodies remains high in patients with autoimmune liver disorders (∼100%). It is therefore recommended that patients with autoimmune hepatitis and positive tTG-IgA be tested for anti-endomysial antibody prior to intestinal biopsy to avoid unnecessary endoscopy and biopsy [137,141]. …”

Section: Autoimmune Diseases Associated With Csmentioning

confidence: 99%

Celiac sprue: a unique autoimmune disorder

Rashtak

Marietta

Murray³

2009

Expert Review of Clinical Immunology

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Celiac sprue (CS) is a gluten-sensitive enteropathy with many autoimmune features. CS involves multiple organs through immune and nonimmune processes, and is frequently associated with other autoimmune disorders. This article reviews the co-occurrence of CS with autoimmune disorders of the cutaneous, nervous, endocrine, musculoskeletal, gastrointestinal and cardiovascular systems. The types of autoimmune disorders associated with CS and the prevalence of CS in other autoimmune disorders are also discussed. A brief review of the literature on the potential mechanisms behind these associations and the therapeutic effects of a gluten-free diet for autoimmune comorbidities in CS is also provided.

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Estudio de enfermedad celíaca en pacientes con enfermedad por hígado graso no alcohólico y con hepatopatías autoinmunes

Cited by 4 publications

References 25 publications

High prevalence of celiac disease in autoimmune hepatitis: Systematic review and meta‐analysis

High prevalence of celiac disease in autoimmune hepatitis: Systematic review and meta‐analysis

Hepatobiliary Disorders in Celiac Disease: An Update

Celiac sprue: a unique autoimmune disorder

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