Evaluation of the antidiabetic action of<i> Mangifera indica</i> in mice

Aderibigbe, AO; Emudianughe, T. S.; Lawal, Bilqis A.

doi:10.1002/ptr.859

Cited by 106 publications

(71 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Single oral administration of a dose of 250 mg/kg body weight produces a potent and strong hypoglycemic effect in type 2 rats. The obtained results are supported by the finding of other investigators (Sharma et al, 1997;Aderibigbe et al, 2001).…”

Section: Discussionsupporting

confidence: 91%

“…Experiment on normal, type 1 and type 2 diabetic model rats at different prandial states have been combined in this experimental approach, which screens materials for hypo-/antihyperglycemic activity as well as provide an approximate idea on the possible target tissue(s) involved. Mangifera indica has been reported to have hypoglycemic effect in both laboratory animals (Ojewole et al, 2005;Muruganandan et al, 2005;Perpetuo et al, 2003;Aderibigbe et al, 2001;Sharma et al, 1997) and human diabetic subjects (Mahabir et al, 1997). The purpose of this work was to evaluate the hypo-and antihyperglycemic effects of M. indica in normal and both type of diabetic model rats and to find out their possible mode(s) of antidiabetic action.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Studies on the antidiabetic effects of Mangifera indica stem-barks and leaves on nondiabetic, type 1 and type 2 diabetic model rats

Bhowmik

Khan

Akhter

et al. 2009

Bangladesh J Pharmacol

View full text Add to dashboard Cite

Studies on the antidiabetic effects of Mangifera indica stem-barks and leaves on nondiabetic, type 1 and type 2 diabetic model rats. Bangladesh J Pharmacol. 2009; 4: 110-14. AbstractMangifera indica Linn, locally known as mango tree has been claimed to possess antidiabetic properties by many investigators. The present study was undertaken to screen the hypoglycemic and antihyperglycemic activity of both ethanol and water extracts of leaves and stem-barks of M. indica in nondiabetic and diabetic model rats in different prandial state. The results showed that all of the extracts had significant antihyperglycemic effect in type 2 diabetic model rats when fed simultaneously with glucose load (p<0.05-0.01; p<0.005-0.001). Moreover, the ethanol extract of stem-barks showed significant antihyperglycemic effect when the extract was fed 30 min prior to the glucose load (p<0.01). Investigations were carried out to evaluate the effect of M. indica on glucose absorption using a rat intestinal preparation in situ. The ethanol extracts of stem-barks reduced glucose absorption gradually This work is licensed under a Creative Commons Attribution 3.0 License. You are free to copy, distribute and perform the work. You must attribute the work in the manner specified by the author or licensor.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Studies on the antidiabetic effects of Mangifera indica stem-barks and leaves on nondiabetic, type 1 and type 2 diabetic model rats

Bhowmik

Khan

Akhter

et al. 2009

Bangladesh J Pharmacol

View full text Add to dashboard Cite

show abstract

“…The leaves of M. indica L. used for antidiabetic properties using normoglycemic, glucose-induced hyperglycemia, and STZ-induced diabetic mice. The aqueous extract of the leaves of M. indica L. possesses hypoglycemic activity [27]. Oral glucose tolerance test in rats mangiferin (10 and 20 mg/kg, i.p.)…”

Section: Resultsmentioning

confidence: 99%

Hypoglycemic Activity of Ten Medicinal Plants Extract in Glucose Induced Mice

Muhtadi

Irenka

Ayu

et al. 2017

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: To evaluate and compare the hypoglycemic activity of 10 medicinal plants extract that is used empirically to treat hyperglycemia in Indonesia, to determine plant with the most potential as a hypoglycemic agent.Methods: Activity test was conducted in Swiss Webster glucose-induced mice with glucose tolerance test. The ethanolic extracts of Mangifera indica L. leaves, Persea americana Mill. leaves, Acorus calamus L. rhizome, Phyllanthus niruri L. herb, Syzygium cumini (L.) skeels bark, Zingiber officinale Roscoe rhizome, Moringa oleifera Lam. leaves, Tamarindus indica L. seed, Momordica charantia L. fruits, and Azadirachta indica A. juss leaves, which were given orally at the same dose of 300 mg/kg bw. The blood samples were used for determination of glucose level examination using a glucose meter and test strips (Accu-Chek). Results:The ethanolic extract of M. indica L. leaves has the best activity in reduction of blood glucose level in mice, followed by Z. officinale Roscoe rhizome, A. calamus L. rhizome, T. indica L. seed., M. charantia L. fruit., S. cumini (L.) skeels bark, P. niruri L. herb., P. americana Mill. leaves, and A. indica A. juss leaves. Conclusion:Results of this study suggest the potential use of M. indica L. leaves extract in the therapy of hyperglycemia.

show abstract

“…This was investigated in gut perfusion experiment where the ethanol extracts showed sudden increase and then a gradual decrease in glucose absorption. Aderibigbe et al 15 claimed that hypoglycemic effect of some plant extracts were compatible with chlorpropamide (oral hypoglycemic agents) and the action may be parts due to an intestinal reduction of the absorption of glucose. Since glucose lowering effect of some plants was clearly evident from previous study reports, glucose absorption inhibition could have been a possible mechanism responsible for the hypoglycemic effect 16 .…”

Section: Discussionmentioning

confidence: 99%

Revelation of Mechanism of Action of Rhizophora Mucronata Poir. Bark Extract for Its Antidiabetic Activity by Gut Perfusion and Six Segment Method in Long Evans Rats

Haque¹,

Ahmed²,

Nasrin³

et al. 2013

Int. Res. J. Pharm.

View full text Add to dashboard Cite

The aqueous bark extract of Rhizophora mucronata Poir. is used in Bangladesh as a hypoglycemic aid without any knowledge about its probable mode of action . It is an effort to assess the claimed hypoglycemic property of the crude drug and to get some knowledge about it. The Hypoglycemic effects were investigated in the ethanol extract of bark of Rhizophora mucronata Poir on Long Evans rats. Gut perfusion and six segments studies were carried out to assess these activities. In gut-perfusion study the percentage of glucose absorption in control rats vs. rats fed with 500 mg/kg extracts were observed at 5, 10, 15, 20, 25 and 30 minutes and the significant (p<0.05) absorption result was found which were respectively 30.71 vs. 56.34, 36.87 vs. 71.30, 35.87 vs. 62.11, 36.64 vs. 70.44, 36.36 vs. 64.21, 35.24 vs. 56.32, The percentage drug unabsorbed in GIT was better with 500 mg/kg than 250 mg/kg. The six-segment study was performed to assess the amount of sucrose remaining in the GIT at six different positions. The amount of sucrose unabsorbed in different GIT segments showed that in control rats vs. rats fed with 500mg/kg extract at 30 minutes in mmol/l was 0.1526 vs. 0.1767 which gradually abating with time dependent manner at 60, 180, and 360 minutes in mmol/l. These results suggests Rhizophora mucronata bark has significant dose dependant anti-diabetic effects, which significantly suppressed postprandial hyperglycemia after sucrose ingestion and reversibly increases the unabsorbed sucrose content throughout the gut.

show abstract

Evaluation of the antidiabetic action of Mangifera indica in mice

Cited by 106 publications

References 4 publications

Studies on the antidiabetic effects of Mangifera indica stem-barks and leaves on nondiabetic, type 1 and type 2 diabetic model rats

Studies on the antidiabetic effects of Mangifera indica stem-barks and leaves on nondiabetic, type 1 and type 2 diabetic model rats

Hypoglycemic Activity of Ten Medicinal Plants Extract in Glucose Induced Mice

Revelation of Mechanism of Action of Rhizophora Mucronata Poir. Bark Extract for Its Antidiabetic Activity by Gut Perfusion and Six Segment Method in Long Evans Rats

Contact Info

Product

Resources

About