Evaluation of the neutrophil–lymphocyte ratio in newly diagnosed nondiabetic hypertensive patients with ascending aortic dilatation

Özde, Cem; Yılmaz, Samet; Korkmaz, Ahmet; Turna, Fahrettin; Şahin, I.; Demir, Vahit

doi:10.1097/mbp.0000000000000187

Cited by 14 publications

(14 citation statements)

References 30 publications

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“…In the hypertension patients, the NLR value increased and positively correlated with hyperhomocysteinemia [19]. In the pathogenesis of aneurysm of the ascending aorta in hypertensive patients, NLR as a marker of inflammation may play an important role [20]. In patients with symptomatic intermediate carotid artery stenosis, NLR was increased and the increased NLR value was an independent variable for carotid artery plaques to become symptomatic [21].…”

Section: Discussionmentioning

confidence: 99%

High Neutrophil-to-Lymphocyte Ratio Predicts Cardiovascular Mortality in Chronic Hemodialysis Patients

Xiong³

et al. 2017

Mediators of Inflammation

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The neutrophil-to-lymphocyte ratio (NLR) is a novel simple biomarker of inflammation. It has emerged as a predictor of poor prognosis in cancer and cardiovascular disease in general population. But little was known of its prognostic value in chronic hemodialysis (HD) patients. Here we investigated the association between NLR and cardiovascular risk markers, including increased pulse pressure (PP), left ventricular mass index (LVMI) and intima-media thickness (IMT), and mortality in HD patients. Two hundred and sixty-eight HD patients were enrolled in this study and were followed for 36 months. The primary end point was all-cause mortality and cardiovascular mortality. Multivariable Cox regression was used to calculate the adjusted hazard ratios for NLR on all-cause and cardiovascular survival. We pinpointed that higher NLR in HD patients was a predictor of increased PP, LVMI, and IMT; HD patients with higher NLR had a lower survival at the end of the study; furthermore, high NLR was an independent predictor of all-cause and cardiovascular mortality when adjusted for other risk factors. In conclusion, higher NLR in HD patients was associated with cardiovascular risk factors and mortality.

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Section: Discussionmentioning

confidence: 99%

High Neutrophil-to-Lymphocyte Ratio Predicts Cardiovascular Mortality in Chronic Hemodialysis Patients

Xiong³

et al. 2017

Mediators of Inflammation

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“…Hypertensive patients with high homocysteine(HCY) had increased NLR and it positively correlated with HCY but not with blood pressure [24]. Also, there was a statistically significant positive correlation between the ascending aortic diameter and NLR ( r = 0.524, P < 0.001), which indicated that it plays a role in the pathogenesis of aneurysm of the ascending aorta in hypertensive patients [25]. In addition, hypertensive patients with diastolic dysfunction had higher values of NLR compared with subjects without diastolic dysfunction.…”

Section: Discussionmentioning

confidence: 99%

The neutrophil-to-lymphocyte ratio on admission is a good predictor for all-cause mortality in hypertensive patients over 80 years of age

Sun

Luo

Zhao

et al. 2017

BMC Cardiovasc Disord

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BackgroundImmuno-inflammation plays a major role in the process of hypertension. We aimed to evaluate the association between inflammatory markers, neutrophil-to-lymphocyte ratio (NLR), red cell distribution width (RDW) and all-cause mortality in elderly patients with hypertension.MethodsA total of 341 hypertensive patients over 80 years of age were included to this study. The NLR and RDW were measured on admission and all the selected patients were followed up for up to 90 days. Kaplan–Meier curves were plotted to evaluate the association between the NLR and the all-cause mortality at follow-up. Using Cox regression models, we investigated the prognostic value of NLR and RDW for all-cause mortality.ResultsPatients with higher quartile of NLR linked to high mortality in hypertensive patients at 90 day after admission (16.47%,13.25%,1.14%,1.17% respectively; χ2 = 20.581,P = 0.000). Surviving patients had lower RDW (13.61 ± 1.37 VS 14.18 ± 1.38, p = 0.041) and NLR (4.97 ± 5.72 VS 7.95 ± 6.88,p = 0.011). The receiver operating curve (ROC) of the NLR for all-cause mortality had an area under the curve (AUC) =0.714 (95%CI: 0.629–0.798, P = 0.000), with acritical value of 2.97, with sensitivity of 92.6%, and a specificity of 52.5%. The ROC of the RDW to predict all-cause mortality, had an AUC =0.654 (95%CI:0.548–0.761, P = 0.008), with acritical value of 13.2%.The Kaplan–Meier curve showed a significant difference between different NLR levels (p = 0.002). Multivariate Cox proportional hazard analysis shown 3rd quartile of NLR(RR = 9.646, 95% CI 1.302–34.457, P = 0.041) and 4th quartiles(RR = 16.451, 95% CI 2.137–66.643, P = 0.007) were found to independently predict all-cause death in hypertensive patients over 80 years of age. Higher rank of NLR was link to higher incidence of all-cause death for such patients.ConclusionThe findings of the present study demonstrate the potential utility of NLR in risk stratification of elderly patients with hypertension to provide information for clinical treatment strategies.

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“…[10] Cem O et al found that NLR is a marker of chronic low grade inflammation and play a role in the pathogenesis of aneurysm of the ascending aorta in hypertensive patients. [16] This studies showing that hypertensives have higher NLR, which has been demonstrated to have the greatest predictive power of death, myocardial infarction and high risk for coronary artery disease and it's an independent predictor of long-term mortality. [17] Research has shown that increased PLR value without absolute thrombocytosis is associated with thrombosis and inflammation, which might be due to an increase in platelet activity.…”

Section: Discussionmentioning

confidence: 90%

Study of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Hypertensives and Normotensives

Mistry

Parmar

2019

IJCEP

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Background and Aim: Long-term hypertension proceed to development of atherothrombotic disease and it's a major healthcare problem worldwide. Platelets and neutrophils play an important role in Cardiovascular (CV) events and development of atherothrombotic disease. Recently, Neutrophil/lymphocyte Ratio (NLR) and Platelet/lymphocyte Ratio (PLR), which can be easily calculated from the differential blood count, have been proposed as novel systemic inflammation-based markers predictive of thrombotic events. The aim of the present study was to explore the association between NLR and PLR with hypertension and as an indicator of cardiovascular risk. Methods: It's a cross sectional study. 50 Hypertensive patients aged 40-60 years, males and females with the history of Previously diagnosed hypertension >1 year duration or taking anti-hypertensive medications with blood pressure Systolic BP > 140 mm Hg, Diastolic BP > 90 mmHg were taken as study group. 50 normotensives aged 40-60, males and females with Systolic BP < 140 mmHg, Diastolic BP < 90 mmHg were taken as control group, who were matching socioeconomically with study group. A detailed history and physiological parameters were taken. Blood pressure was measured via auscultatory method using sphygmomanometer. Under aseptic precautions, 3 ml of venous blood samples were collected and analysed. Results: Neutrophil to Lymphocyte Ratio (NLR) was significantly higher (p<0.01) in study group. Platelet to Lymphocyte Ratio (PLR) was also higher in study group but statistically not significant (p>0.05). Conclusion: Hypertensives with higher NLR have greater risk for athero-thrombotic and atherosclerotic events.

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Evaluation of the neutrophil–lymphocyte ratio in newly diagnosed nondiabetic hypertensive patients with ascending aortic dilatation

Abstract: NLR as a marker of chronic low-grade inflammation may play a role in the pathogenesis of aneurysm of the ascending aorta in hypertensive patients.

Cited by 14 publications

References 30 publications

High Neutrophil-to-Lymphocyte Ratio Predicts Cardiovascular Mortality in Chronic Hemodialysis Patients

High Neutrophil-to-Lymphocyte Ratio Predicts Cardiovascular Mortality in Chronic Hemodialysis Patients

The neutrophil-to-lymphocyte ratio on admission is a good predictor for all-cause mortality in hypertensive patients over 80 years of age

Study of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Hypertensives and Normotensives

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