Evaluation of wound healing and antimicrobial properties of aqueous extract from Bowdichia virgilioides stem barks in mice

Agra, Isabela Karine Rodrigues; Pires, Luana Luzia Santos; Carvalho, Paulo S.M.; Silva-Filho, Euripedes A.; Smaniotto, Salete; Barreto, Emiliano

doi:10.1590/s0001-37652013005000049

Cited by 38 publications

(37 citation statements)

References 20 publications

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“…However, prolonged inflammation phase causes delaying of healing process. [16] Anti-inflamatory activity of yacon leaves extract plays a role for shorten the healing period.…”

Section: Macroscopic Evaluation Of Wound Healingmentioning

confidence: 99%

Antihyperglycemic and diabetic wound healing activity of smallanthus sonchifolius leaves extract

et al. 2018

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Diabetic patient tend to suffer from lower extremity complication that contribute to the occurence of diabetic foot ulcer. Smallanthus sonchifolius or yacon leaves extract has been used as an alternative medicine for diabetes and also showed antibacterial activity. This research aims to obtain the antihyperglycemic and diabetic wound healing activity of yacon leaves extract. Diabetic condition of rat was induced by streptozotocin (45 mg/kg bw) and nicotinamide (110 mg/kg bw). Rats were then allowed to develop diabetes for 21 days. A biopsy punch then was used to create a wound. Yacon leaves extract were administered by oral and topical for 14 day. The serum glucose level and diameter of the wound were measured every week, and histopatology study of the skin was conducted at the end of the study. Oral administration of yacon leaves extract (150 mg/kg bw) together with topical administration showed antihyperglycemic as well as diabetic wound healing activities comparable to the reference drugs (glibenclamide oral and nebacetin cream).

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“…However, prolonged inflammation phase causes delaying of healing process. [16] Anti-inflamatory activity of yacon leaves extract plays a role for shorten the healing period.…”

Section: Macroscopic Evaluation Of Wound Healingmentioning

confidence: 99%

Antihyperglycemic and diabetic wound healing activity of smallanthus sonchifolius leaves extract

et al. 2018

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“…For wound healing and antimicrobial properties, a study employed by Agra et al . [ 15 ] showed that the aqueous extract from Bowdichia virgilioides stem barks can be used in mice. Jiao et al .…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory activity of Jatropha curcas Linn. latex in cream formulation on CD68 expression in mice skin wound

et al. 2018

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Aim:The purpose of the present study was to determine the potential of Jatropha curcas latex in the cream formulation on CD68 immune expression (macrophages) during inflammatory phase wound healing process in mice skin.Materials and Methods:Amount of 12 two-months-old male mice were used between 30 and 40 g. To surgical procedures, wound skin incision was performed 2.0 cm in length until subcutaneous on the paravertebral of each animal. The treatment was carried under locally anesthetized with procaine cream. The mice were allotted into four groups of each, entire surface of each group wound covered by base cream control, sulfadiazine 0.1% cream, J. curcas latex cream 10% and, 15%, respectively. All experiments were performed twice a day for 3 days. The wound healing was assayed in stained histological sections in immunohistochemical of the wounds. CD68 expression was investigated under a microscope.Results:The results showed that the cream from the 10% and 15% latex of J. curcas revealed moderate immune reaction to CD68 on wound healing.Conclusion:We concluded that the latex cream of J. curcas possesses anti-inflammatory activity in wound healing process of mice skin.

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“…This delay in wound healing may be due to flavine being a disinfectant and therefore kill new immature cells while having no inherent proliferative properties. As a comparison, L. pumila is an excellent wound healing agent with proliferative properties and has inherent antimicrobial properties to prevent wound infection (Agra et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Labisia pumila improves wound healing process in ovariectomized rat model

Ahmad

Shuid

Mohamed

2018

Bangladesh J Pharmacol

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Labisia pumila (Blume) Fern.-Vill. synonym Marantodes pumilum (Blume) Kuntze is a flowering plant of the Primulaceae family. It is used traditionally by the Malay women to shrink the uterus, facilitate labor, improve menstrual irregularities and as post-partum medicine (Runi, 2000). The ethnopharmacological studies and clinical findings have illustrated that L. pumila possesses many biological functions, including phytoestrogenic, antimicrobial, anti-oxidative, anti-inflammatory properties and anti-aging (Choi et al., 2010;Nadia et al., 2012). Recent studies on L. pumila also demonstrated that it could also be used for osteoporosis, cardiovascular diseases, and metabolic disorders (Shuid et al., 2011). The ethnobotanical and therapeutic properties of L. pumila make it a potential source of novel medicine for the healing of wounds. Therefore, this study investigates the effectiveness of topical application of the aqueous extract of L. pumila on the rate of wound closure and the histology of the wound area. Materials and Methods Plant collection and extractionThe plant species were collected from their natural habitat in the rainforest of Taiping, Perak, Malaysia in October, 2014. Identification of the plant species was verified by a botanist from the Faculty of Science, Universiti Kebangsaan Malaysia (UKM). All voucher specimens were deposited in the Herbarium of UKM (voucher specimen number of L. pumila var. alata = UKMB 30006/SM 2622 and var. pumila = UKMB 30007/ SM s.n.). The standardized aqueous extraction method was used according to Jamal et al. (2003) AbstractThe purpose of this study was to determine the wound healing effect of Labisia pumila in the ovariectomized rat model. Ninety-nine Sprague Dawley female rats equally divided into nine groups; where five were control groups, and four were treated groups. The dressing was changed daily, starting from the wound induction until complete healing. The percentage of wound contraction was measured on day 0, 2, 5, 8, 9, 10, 11, 12 and 13. Three rats were sacrificed from each group on day 2, 5 and 8 respectively for evaluating of histological assessments. Wounds dressed with extract showed considerable healing and significantly healed faster compared to all control groups (p<0.05). Moreover, histological analysis revealed remarkable reduction in the scar width correlated with the enhanced collagen content and fibroblast cells, accompanied by a reduction of inflammatory cells in the granulation tissues.In conclusion, L. pumila may promote wound healing in postmenopausal rat model. Article Info

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Evaluation of wound healing and antimicrobial properties of aqueous extract from Bowdichia virgilioides stem barks in mice

Cited by 38 publications

References 20 publications

Antihyperglycemic and diabetic wound healing activity of smallanthus sonchifolius leaves extract

Antihyperglycemic and diabetic wound healing activity of smallanthus sonchifolius leaves extract

Anti-inflammatory activity of Jatropha curcas Linn. latex in cream formulation on CD68 expression in mice skin wound

Labisia pumila improves wound healing process in ovariectomized rat model

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