Expression of CD34 and CD105 as markers for angiogenesis in oral vascular malformations and pyogenic granulomas

Abstract

The objective of this study was to assess angiogenic activity by analyzing anti-CD105 and anti-CD34 immunostaining in 20 cases of vascular malformations (VMs) and 20 cases of oral pyogenic granulomas (OPG). In addition, the usefulness of these markers for the differential diagnosis of these two oral tumors was evaluated. The results showed no significant difference in mean microvessel count between the anti-CD105 (P = 0.803) and anti-CD34 (P = 0.279) antibody. The mean number of vessels was 18.75 and 59.72 for oral VMs immunostained with anti-CD105 and anti-CD34 antibody, respectively, whereas in OPG the mean number was 20.22 and 48.09, respectively. CD34 was found to be more effective than CD105 in identifying blood vessels. However, the anti-CD105 antibody seems to be more related to vascular neoformation. Overall, this study supports the role of angiogenic factors in the etiopathogenesis of oral VMs and PG, but the results showed that quantification of angiogenesis cannot be used as a marker for the differential diagnosis of these two types of lesions.

Study of the etiopathogenesis and differential diagnosis of oral vascular lesions by immunoexpression of GLUT‐1 and HIF‐1α

“…, Buckmiller, Suen , and Vasconcelos et al. . According to these authors, the histological differential diagnosis between hemangioma and VM or PG is difficult as hemangioma is histologically similar to VM during the process of involution, whereas inflamed hemangioma resembles PG.…”

Immunohistochemical Evaluation of Angiogenesis and Tryptase-positive Mast Cell Infiltration in Periapical Lesions

“…By contrast, CD105 (endoglin) is predominantly expressed on cycling vascular endothelial cells in reactive and neoplastic tissues, all of which undergo active angiogenesis (11). In the oral cavity, several studies have been performed to quantify MVD by using CD34 and CD105 (12)(13)(14), but only one study assessed periapical lesions (15). In the current study, we have considered of interest the analysis of possible correlations between CD105 and CD34 pattern and tryptase-positive MCs in periapical lesions.…”

FASN expression, angiogenesis and lymphangiogenesis in central and peripheral giant cell lesions

“…CD105 (endoglin) is an angiogenic membrane protein that is highly expressed in neoformed vessels 6 . Although CD105 has been assessed in oral vascular malformations and pyogenic granulomas 26 , to our knowledge, CD105 expression in GCL of the jaws is unknown. Another unclear and relevant point is the characterization of the lymphatic MVD (LMVD) in GCL, which may be immunohistochemically evaluated through the D2-40 marker 13 .…”