Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography Is Useless for the Detection of Local Recurrence after Radical Prostatectomy

Incidental Abnormal FDG Uptake in the Prostate on 18-fluoro-2-Deoxyglucose Positron Emission Tomography-Computed Tomography Scans

“…Consistent with the current study, several clinical reports revealed no significant difference in the 18 F-FDG activity of primary prostatic adenocarcinoma compared with BPH, and that the correlation coefficient between PSA levels and SUVmax was very low (Hofer et al, 1999;Shiiba et al, 2012).…”

Incidental diagnosis of a PSA-negative prostate cancer by 18FDG PET/CT in a patient with hypopharyngeal cancer

“…This has to be emphasized as these biochemical findings are sometimes unspecific and may also be found in patients with nonmalignant diseases of the prostate gland such as benign hyperplasia, prostatitis or even in healthy individuals. [2][3][4][5][6]9,[12][13][14][15][16][17][18] Even the described slight increase of the PSA level from 1.68 to 2.21 ng/ml after 2 years, which consecutively decreased to 1.9 ng/ml at the time of surgery, or a potential rise of the percent-free PSA in relation to total PSA, would not have required a prostate biopsy in any case as, despite the described rise of the PSA, PSA levels were still within and even not at the upper limit (4.0 ng/ml) of the normal range. In addition, estimation of percent-free PSA is also prone to variations between malignant and benign masses of the prostate.…”

“…11 Consequently, several previously published studies failed to show a beneficial impact of FDG-PET, except in the detection and localization of distant metastases in hormone-refractory PC. 2,5,6,9,[12][13][14][15] Additionally, even the recently introduced PET/CT technique, adding morphological information to metabolic data of FDG-PET, failed to improve the diagnostic value of FDG-PET imaging for PC in a small series of patients. 15 Data regarding new radiotracers for the diagnosis of PC, for example 11 C-choline, seem to have a beneficial impact on the diagnostic value as compared to FDG-PET, but data are still discussed controversially and, as of yet, failed to show a significant correlation between the uptake of 11 C-choline and tumor grade or Gleason score.…”

Valor de la PET en la recurrencia del cáncer de próstata con PSA < 5 ng/ml

“…Los estudios preliminares utilizaban como radiotrazador la glucosa marcada con flúor, en forma de 18 fluoro-2-desoxiglucosa ( 18 F-FDG), radiotrazador que se emplea comúnmente para la evaluación metabólica de múltiples procesos neoplá-sicos. La limitación de su rendimiento, debido a la baja captación celular de 18 F-FDG, ha sido ampliamente demostrada en el cáncer de próstata [11][12][13][14][15] ; posiblemente pueda utilizarse para evaluar la agresividad y la resistencia androgénica 16 , quedando relegado a pacientes con PSA entre 2 y 10 ng/ml 17 .…”