Functional activity mapping of the mesial hemispheric wall during anticipation of pain

Porro, Carlo Adolfo; Cettolo, Valentina; Francescato, Maria Pia; Baraldi, Patrizia

doi:10.1016/s1053-8119(03)00184-8

Cited by 145 publications

(89 citation statements)

References 47 publications

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“…In particular, pain unpleasantness is mainly encoded in the ACC [9]. Then, anticipation of pain may, itself, induce changes in brain nociceptive networks [10]. Moreover, recent experimental evidence has been provided, by means of functional magnetic resonance imaging, of a strict similarity in the processing of both hypnotically and physically induced experience of pain; the subjective dimension of pain (in the absence of any noxious stimulus) seems to involve brain regions (ACC, thalamus, insula, cerebellum, prefrontal and parietal cortices) variously described as belonging to the pain network [3,4].…”

Section: Discussionmentioning

confidence: 99%

Cortical involvement during the description of head pain

et al. 2006

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Pain perception involves several cortical areas. Our purpose was to examine cortical activity in patients describing their cephalic pain with the MacGill Pain Questionnaire (MPQ). Two SPECT analyses were performed in pain-free periods in 10 patients with migraine (n=8) or myogenous facial pain (n=2). The MPQ was administered in the first session, while no task was to be performed during the second session. Differences were calculated using statistical parametric mapping (SPM99), also taking the MPQ pain rating index (PRI) as covariance.During the MPQ session, clusters of activation were observed in the orbitofrontal cortex, the insula and the anterior cingulate cortex (ACC) of the left brain, but not significantly so. Using the MPQ PRI as covariate, significant areas of activation were found in the left frontal lobe, the Brodmann area 32 and in the ACC. The description of pain seems to activate cortical areas similar to those involved in actual pain perception.

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Section: Discussionmentioning

confidence: 99%

Cortical involvement during the description of head pain

et al. 2006

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“…Areas of the ACC that represent pain affect are also active in anticipation of painful stimuli (Hsieh, StoneElander, & Ingvar, 1999;Koyama, Tanaka, & Mikami, 1998;Porro, Cettolo, Francescato, & Baraldi, 2003), including stimulus-specific anticipatory discharge of neurons in area 24b (Hutchison et al, 1999). The relationship between anticipation and empathy in visually cued pain representations in the ACC may thus be a very close one, both functionally and subjectively.…”

Section: A Common Neural Substrate For Felt and Seen Painmentioning

confidence: 99%

“…In the ACC, nociceptive neurons are interspersed among cells that code for the aversive value of the stimulus (Koyama, Kato, Tanaka, & Mikami, 2001;Porro et al, 2003). Projections from the anterior cingulate of area 24b reach supplementary motor, premotor, cingulate motor, and primary motor cortices, influencing the selection of skeletomotor responses to painful stimuli (Devinsky et al, 1995;Matelli, Luppino, & Rizzolatti, 1991;Vogt et al, 1995).…”

Section: Vicarious Pain As a Motivational-affective Representationmentioning

confidence: 99%

Vicarious responses to pain in anterior cingulate cortex: Is empathy a multisensory issue?

Morrison

Lloyd

Pellegrino

et al. 2004

Cognitive, Affective, & Behavioral Neuroscience

437

261

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Results obtained with functional magnetic resonance imaging show that both feeling a moderately painful pinprick stimulus to the fingertips and witnessing another person's hand undergo similar stimulation are associated with common activity in a pain-related area in the right dorsal anterior cingulate cortex (ACC). Common activity in response to noxious tactile and visual stimulation was restricted to the right inferior Brodmann's area 24b. These results suggest a shared neural substrate for felt and seen pain for aversive ecological events happening to strangers and in the absence of overt symbolic cues. In contrast to ACC 24b, the primary somatosensory cortex showed significant activations in response to both noxious and innocuous tactile, but not visual, stimuli. The different response patterns in the two areas are consistent with the ACC's role in coding the motivational-affective dimension of pain, which is associated with the preparation of behavioral responses to aversive events.

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“…The prefrontal cortex (PFC), anterior insula, and anterior cingulate cortex (ACC) are activated during the anticipation of pain, but their exact role in pain expectation remains poorly delineated (9)(10)(11)(12). Moreover, the neural mechanisms by which conscious predictions about the magnitude of pain influence the experience of pain remain poorly understood and largely unexploited in the treatment of pain.…”

mentioning

confidence: 99%

The subjective experience of pain: Where expectations become reality

Koyama

McHaffie

Laurienti

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

620

408

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Our subjective sensory experiences are thought to be heavily shaped by interactions between expectations and incoming sensory information. However, the neural mechanisms supporting these interactions remain poorly understood. By using combined psychophysical and functional MRI techniques, brain activation related to the intensity of expected pain and experienced pain was characterized. As the magnitude of expected pain increased, activation increased in the thalamus, insula, prefrontal cortex, anterior cingulate cortex (ACC) and other brain regions. Pain-intensityrelated brain activation was identified in a widely distributed set of brain regions but overlapped partially with expectation-related activation in regions, including the anterior insula and ACC. When expected pain was manipulated, expectations of decreased pain powerfully reduced both the subjective experience of pain and activation of pain-related brain regions, such as the primary somatosensory cortex, insular cortex, and ACC. These results confirm that a mental representation of an impending sensory event can significantly shape neural processes that underlie the formulation of the actual sensory experience and provide insight as to how positive expectations diminish the severity of chronic disease states.functional MRI ͉ mental imagery ͉ placebo ͉ psychophysical T he experience of a sensory event is highly subjective and can vary substantially from one individual to the next (1). Much of this individual variation may result from the manner in which past experience and future predictions about a stimulus are used to interpret afferent information. Consistent pairing of environmental cues with sensory events provides a learned historical context that is critically important for the prediction and processing of future sensations (2, 3). However, expectations that are inconsistent with sensory information can dramatically alter the sensory experience. In the case of pain, positive expectations can powerfully reduce the subjective experience of pain evoked by a consistently noxious stimulus, whereas negative expectations may result in the amplification of pain (4-7). Furthermore, expectations in which there is a high degree of certainty as to the outcome may activate descending control systems to diminish pain, whereas expectations associated with uncertain outcomes may amplify pain (8).The prefrontal cortex (PFC), anterior insula, and anterior cingulate cortex (ACC) are activated during the anticipation of pain, but their exact role in pain expectation remains poorly delineated (9-12). Moreover, the neural mechanisms by which conscious predictions about the magnitude of pain influence the experience of pain remain poorly understood and largely unexploited in the treatment of pain. At the most fundamental level, expectation-induced modulation of pain must necessarily engage three neural processes. First, an active mental representation of an impending event must be formulated by incorporating past information with the present context and future implica...

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Functional activity mapping of the mesial hemispheric wall during anticipation of pain

Cited by 145 publications

References 47 publications

Cortical involvement during the description of head pain

Cortical involvement during the description of head pain

Vicarious responses to pain in anterior cingulate cortex: Is empathy a multisensory issue?

The subjective experience of pain: Where expectations become reality

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