Gold nanoparticles with surface-anchored chiral poly(acryloyl-L(D)-valine) induce differential response on mesenchymal stem cell osteogenesis

Deng, Jun; Zheng, Honghao; Zheng, Xiaowen; Mengyun, Yao; Li, Zheng; Gao, Changyou

doi:10.1007/s12274-016-1239-y

Cited by 50 publications

(40 citation statements)

References 56 publications

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“…This osteogenic differentiation-inducing capacity was evidenced through the upregulation of the osteogenic differentiation-related genes, namely alkaline phosphatase (ALP), osteopontin (OPN), osteocalcin (OCN), and Runt-related transcription factor 2 (RUNX2) [ 120 ]. The chirality of the surface of AuNPs through the anchoring of the chiral poly (acryloyl- l ( d )-valine) ( l ( d )- PAV) to finally produce l ( d )-PAV-AuNPs, which led to the promotion of the osteogenic differentiation of MSCs [ 121 ]. l ( d )-PAV-AuNPs-exposed MSCs showed upregulation of osteogenic differentiation marker genes such as OCN and collagen type I (COL I), activation of mitogen-activated protein kinase (MAPK)/p38 pathway, and calcium mineralization [ 121 ].…”

Section: Metallic Nps and Stem Cell Differentiation And Proliferatmentioning

confidence: 99%

“…The chirality of the surface of AuNPs through the anchoring of the chiral poly (acryloyl- l ( d )-valine) ( l ( d )- PAV) to finally produce l ( d )-PAV-AuNPs, which led to the promotion of the osteogenic differentiation of MSCs [ 121 ]. l ( d )-PAV-AuNPs-exposed MSCs showed upregulation of osteogenic differentiation marker genes such as OCN and collagen type I (COL I), activation of mitogen-activated protein kinase (MAPK)/p38 pathway, and calcium mineralization [ 121 ].…”

Section: Metallic Nps and Stem Cell Differentiation And Proliferatmentioning

confidence: 99%

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The Impact of Metallic Nanoparticles on Stem Cell Proliferation and Differentiation

2018

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Nanotechnology has a wide range of medical and industrial applications. The impact of metallic nanoparticles (NPs) on the proliferation and differentiation of normal, cancer, and stem cells is well-studied. The preparation of NPs, along with their physicochemical properties, is related to their biological function. Interestingly, various mechanisms are implicated in metallic NP-induced cellular proliferation and differentiation, such as modulation of signaling pathways, generation of reactive oxygen species, and regulation of various transcription factors. In this review, we will shed light on the biomedical application of metallic NPs and the interaction between NPs and the cellular components. The in vitro and in vivo influence of metallic NPs on stem cell differentiation and proliferation, as well as the mechanisms behind potential toxicity, will be explored. A better understanding of the limitations related to the application of metallic NPs on stem cell proliferation and differentiation will afford clues for optimal design and preparation of metallic NPs for the modulation of stem cell functions and for clinical application in regenerative medicine.

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Section: Metallic Nps and Stem Cell Differentiation And Proliferatmentioning

confidence: 99%

Section: Metallic Nps and Stem Cell Differentiation And Proliferatmentioning

confidence: 99%

The Impact of Metallic Nanoparticles on Stem Cell Proliferation and Differentiation

2018

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“…5D). 150 (2) Silver nanoparticles. Silver nanoparticles (AgNPs) have drawn appealing lights in regenerative medicine due to their excellent antimicrobial properties.…”

Section: Hard Nanomaterialsmentioning

confidence: 99%

“…NPs can easily transfer across cells membranes and distribute in the cytoplasm or lysosome, thus activating or inhibit certain cellular signaling pathways for differentiation induction or inhibition. 172,173 NPs are internalized via different endocytosis pathways 150,174 including clathrin-mediated endocytosis, caveolin-mediated endocytosis, macropinocytosis and clathrin-and caveolin-independent endocytosis, cellular internalization of NPs and the possible mechanism of differentiation induced by NPs are signicantly inuenced by the physicochemical properties of NPs, such as size, shape, hydrophobicity, soness, composition and surface chemistry of nanoparticle surfaces. 4 The optimal size of NPs for stem cell differentiation almost ranges from 20 nm to 70 nm possibly due to the size-dependent cellular uptake rates.…”

Section: The Interactions Between Nps and Stem Cells And Possible Undmentioning

confidence: 99%

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Recent review of the effect of nanomaterials on stem cells

Yuan

et al. 2018

RSC Adv.

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Chirality Controls Mesenchymal Stem Cell Lineage Diversification through Mechanoresponses

Wei

Jiang

et al. 2019

Advanced Materials

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Biogenesis and tissue development are based on the heterogenesis of multipotent stem cells. However, the underlying mechanisms of stem cell fate specification are unclear. Chirality is one of the most crucial factors that affects stem cell development and is implicated in asymmetrical cell morphology formation; however, its function in heterogeneous cell fate determination remains elusive. In this study, it is reported that the chirality of a constructed 3D extracellular matrix (ECM) differentiates mesenchymal stem cells to diverse lineages of osteogenic and adipogenic cells by providing primary heterogeneity. Molecular analysis shows that left‐handed chirality of the ECM enhances the clustering of the mechanosensor Itgα5, while right‐handed chirality decreases this effect. These differential adhesion patterns further activate distinct mechanotransduction events involving the contractile state, focal adhesion kinase/extracellular signal‐regulated kinase 1/2 cascades, and yes‐associated protein/runt‐related transcription factor 2 nuclear translocation, which direct heterogeneous differentiation. Moreover, theoretical modeling demonstrates that diverse chirality mechanosensing is initiated by biphasic modes of fibronectin tethering. The findings of chirality‐dependent lineage specification of stem cells provide potential strategies for the biogenesis of organisms and regenerative therapies.

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Gold nanoparticles with surface-anchored chiral poly(acryloyl-L(D)-valine) induce differential response on mesenchymal stem cell osteogenesis

Cited by 50 publications

References 56 publications

The Impact of Metallic Nanoparticles on Stem Cell Proliferation and Differentiation

The Impact of Metallic Nanoparticles on Stem Cell Proliferation and Differentiation

Recent review of the effect of nanomaterials on stem cells

Chirality Controls Mesenchymal Stem Cell Lineage Diversification through Mechanoresponses

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