Hydrogels for biomedical applications from glycol chitosan and PEG diglycidyl ether exhibit pro-angiogenic and antibacterial activity

Tripodo, Giuseppe; Trapani, Adriana; Rosato, Antonio; Franco, Cinzia Di; Tamma, Roberto; Trapani, Giuseppe; Ribatti, Doménico; Mandracchia, Delia

doi:10.1016/j.carbpol.2018.06.061

Cited by 67 publications

(50 citation statements)

References 31 publications

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“…PEG is generally considered to have low toxicity by all routes of administration 18 : its metabolism was reviewed by Webster et al 19 The molecular weight of PEGD is not known. In general, PEG is not considered biodegradable except for low molecular weight species (<400 Da) that may be degraded by alcohol dehydrogenase in vivo 5,6,19‐32 …”

Section: Introductionmentioning

confidence: 99%

“…In general, PEG is not considered biodegradable except for low molecular weight species (<400 Da) that may be degraded by alcohol dehydrogenase in vivo. 5,6,[19][20][21][22][23][24][25][26][27][28][29][30][31][32] Its application as a crosslinker for HA hydrogels stems from the combination of its low toxicity and the good rheological properties of PEG crosslinked hydrogels. 33 The aim of this study was to evaluate the chemical, viscoelastic and biological properties of a recently introduced hydrogel based on PEG-crosslinked HA with a high concentration of HA (28 mg/mL), commercialized as Neauvia Intense (MatexLab, SA).…”

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confidence: 99%

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Chemical and mechanical characterization of hyaluronic acid hydrogel cross‐linked with polyethylen glycol and its use in dermatology

Zerbinati

Esposito²,

Cipolla³

et al. 2020

Dermatologic Therapy

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Hydrogels based on hyaluronic acid are used to restore volume, hydration, and skin tone, as well as to correct scars, asymmetries or defects of the soft tissue. Hyaluronic acid is often chemically crosslinked with different crosslinking agents in order to improve its mechanical and biological properties. Here we focused on defining the chemical and mechanical characterization of a new hydrogel with specific characteristics: hyaluronic acid polyethylene glycol (PEG)‐crosslinked with a high concentration of hyaluronic acid (28 mg/mL), manufactured by MatexLab Spa, via Carlo Urbani 2, ang Via Enrico Fermi, Brindisi, Italy. We made a quantitative and qualitative analysis of the content of sodium hyaluronate in the hydrogel after polymerization and sterilization processes and also evaluated histologically the bio integration of these hydrogels in the cutaneous soft tissues. The results suggest that hyaluronic acid hydrogel PEG‐crosslinked have great bio integration, great chemical and mechanical properties, compared with other products available on the market, that are cross‐linked with different cross‐linking agents. The nontoxicity and nonimmunogenicity of PEG guarantee the lack of allergic and immunological reactions. The PEG‐crosslinking technology guarantees a high duration time of the implanted hydrogel because of more resistant physiological degradation.

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Chemical and mechanical characterization of hyaluronic acid hydrogel cross‐linked with polyethylen glycol and its use in dermatology

Zerbinati

Esposito²,

Cipolla³

et al. 2020

Dermatologic Therapy

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“…For biomedical applications, among the most used polymers for hydrogel preparation, the great family of polysaccharides should be mentioned. Hyaluronic acid [ 3 ], chitosan and derivatives [ 4 ], dextran [ 5 ], alginate [ 6 ], cellulose [ 7 ] and heparin [ 8 ] are among the most used. Polysaccharides are also employed for colon drug delivery because most of them are specifically degraded from intestinal microflora [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

A Micellar-Hydrogel Nanogrid from a UV Crosslinked Inulin Derivative for the Simultaneous Delivery of Hydrophobic and Hydrophilic Drugs

et al. 2018

Self Cite

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Hydrogels are among the most common materials used in drug delivery, as polymeric micelles are too. They, preferentially, load hydrophilic and hydrophobic drugs, respectively. In this paper, we thought to combine the favorable behaviors of both hydrogels and polymeric micelles with the specific aim of delivering hydrophilic and hydrophobic drugs for dual delivery in combination therapy, in particular for colon drug delivery. Thus, we developed a hydrogel by UV crosslinking of a methacrylated (MA) amphiphilic derivative from inulin (INU) (as known INU is specifically degraded into the colon) and vitamin E (VITE), called INVITEMA. The methacrylated micelles were physicochemically characterized and subjected to UV irradiation to form what we called the “nanogrids”. The INVITEMA nanogrids were characterized by DSC, SEM, TEM, water uptake and beclomethasone dipropionate (BDP) release. In particular, the release of the hydrophobic drug was specifically assessed to verify that it can spread along the hydrophilic portions and, therefore, effectively released. These systems can open new pharmaceutical applications for known hydrogels or micelle systems, considering that in literature only few examples are present.

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“…2 Many research groups have prepared CS-based hydrogels as tissue scaffolds for the delivery of antibiotics and to promote tissue repair such as cardiac repair and bone regeneration. [22][23][24][25] In addition, CS and glycerol phosphate disodium salt (GP) could be prepared as a thermosensitive hydrogel that has a low viscosity at lower critical solution temperature and turns into a gel state at higher critical solution temperature to fill irregular bone sites. 26 Drug release from CS-gels commonly follows physical diffusion in which the drug cumulative release time only reaches 1-5 days.…”

Section: Introductionmentioning

confidence: 99%

<p>Injectable Chitosan-Based Thermosensitive Hydrogel/Nanoparticle-Loaded System for Local Delivery of Vancomycin in the Treatment of Osteomyelitis</p>

Jin¹,

Zhang²,

Shen³

et al. 2020

IJN

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Purpose: Osteomyelitis, particularly chronic osteomyelitis, remains a major challenge for orthopedic surgeons. The traditional treatment for osteomyelitis, which involves antibiotics and debridement, does not provide a complete solution for infection and bone repair. Antibiotics such as vancomycin (VCM) are commonly used to treat osteomyelitis in clinical settings. VCM use is limited by a lack of effective delivery methods that provide sustained, high doses to entirely fill irregular bone tissue to treat infections. Methods: We engineered a chitosan (CS)-based thermosensitive hydrogel to produce a VCM-nanoparticle (NPs)/Gel local drug delivery system. The VCM-NPs were formed with quaternary ammonium chitosan and carboxylated chitosan nanoparticles (VCM-NPs) by positive and negative charge adsorption to enhance the encapsulation efficiency and drug loading of VCM, with the aim of simultaneously preventing infection and repairing broken bones. This hydrogel was evaluated in a rabbit osteomyelitis model. Results: The VCM-NPs had high encapsulation efficiency and drug loading, with values of 60.1±2.1% and 24.1±0.84%, respectively. When embedded in CS-Gel, the VCM-NPs maintained their particle size and morphology, and the injectability and thermosensitivity of the hydrogel, which were evaluated by injectability test and rheological measurement, were retained. The VCM-NPs/Gel exhibited sustained release of VCM over 26 days. In vitro tests revealed that the VCM-NPs/Gel promoted osteoblast proliferation and activity against Staphylococcus aureus. In vivo, VCM-NPs/Gel (with 10 mg vancomycin per rabbit) was used to treat rabbits with osteomyelitis. The VCM-NPs/Gel showed excellent anti-infection properties and accelerating bone repair under osteomyelitis conditions. Conclusion: The reported multifunctional NPs hydrogel system for local antibiotic delivery (VCM-NPs/Gel) showed bone regeneration promotion and anti-infection properties, demonstrating significant potential as a scaffold for effective treatment of osteomyelitis.

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Hydrogels for biomedical applications from glycol chitosan and PEG diglycidyl ether exhibit pro-angiogenic and antibacterial activity

Cited by 67 publications

References 31 publications

Chemical and mechanical characterization of hyaluronic acid hydrogel cross‐linked with polyethylen glycol and its use in dermatology

Chemical and mechanical characterization of hyaluronic acid hydrogel cross‐linked with polyethylen glycol and its use in dermatology

A Micellar-Hydrogel Nanogrid from a UV Crosslinked Inulin Derivative for the Simultaneous Delivery of Hydrophobic and Hydrophilic Drugs

<p>Injectable Chitosan-Based Thermosensitive Hydrogel/Nanoparticle-Loaded System for Local Delivery of Vancomycin in the Treatment of Osteomyelitis</p>

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