Propionibacterium acnes Has Low Susceptibility to Chlorhexidine Digluconate

Nakase, Keisuke; Fukushima, Hanae; Yukawa, Tomoko; Nakaminami, Hidemasa; Fujii, Takeshi; Noguchi, Norihisa

doi:10.1089/sur.2017.220

Cited by 16 publications

(9 citation statements)

References 13 publications

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“…Hagi et al reported that bactericidal activity of olanexidine gluconate against various bacterial species was compared to CHG and PI by determination of minimum bactericidal concentration. 9) They used 100 species including Enterococcus faecalis, VRE, Staphylococcus aureus, MRSA, Staphylococcus epidermidis, Streptococcus pyogenes, Cutibacterium acnes, Acinetobacter baumannii, Burkholderia cepacia, Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Proteus mirabilis, Proteus hauseri, Pseudomonas aeruginosa, Salmonella Typhimurium, Serratia marcescens, Stenotrophomonas maltophilia, and Bacteroides fragilis, which were also used in this study. The data showed that olanexidine gluconate had high bactericidal activity as well or better than CHG and PI.…”

Section: Resultsmentioning

confidence: 99%

“…Olanexidine gluconate exerts strong and fastacting bactericidal activity against wide range of bacteria. 9) The bactericidal mechanism has been reported to occur via an interaction with the bacterial surface molecules, such as lipopolysaccharide and lipoteichoic acid, which subsequently disrupts cell membranes and degrades proteins. 9) Therefore, the bactericidal effect of olanexidine gluconate is irreversible owing to the loss of intracellular components.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of in Vitro Bactericidal Activity of 1.5% Olanexidine Gluconate, a Novel Biguanide Antiseptic Agent

Seyama

Nishioka

Nakaminami

et al. 2019

Biological & Pharmaceutical Bulletin

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Recently, 1.5% olanexidine gluconate, a biguanide compounds, was launched as a new antiseptic agent in Japan. However, the comprehensive bactericidal spectrum of olanexidine gluconate is still unknown. In this study, we evaluated in vitro bactericidal activity of olanexidine gluconate using time-kill assay against various bacteria, mycobacteria, and fungi. With the exception of Burkholderia cepacia and Mycobacterium spp., 1.5% olanexidine gluconate exhibited fast-acting (≤60 s) bactericidal activity against all tested Gram-positive and Gram-negative bacteria, including vancomycin-resistant Enterococcus faecalis, methicillin-resistant Staphylococcus aureus, methicillin-resistant Staphylococcus epidermidis, extended spectrum β-lactamase producing Klebsiella pneumoniae, and multidrug-resistant Pseudomonas aeruginosa. Furthermore, 1.5% olanexidine gluconate eradicated Candida albicans, Microsporum canis, and Malassezia furfur within 3 min. Our findings indicate that olanexidine gluconate has broad spectrum bactericidal activity; therefore, it may be useful for the prevention of a wide range of infectious diseases.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of in Vitro Bactericidal Activity of 1.5% Olanexidine Gluconate, a Novel Biguanide Antiseptic Agent

Seyama

Nishioka

Nakaminami

et al. 2019

Biological & Pharmaceutical Bulletin

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“…The study showed that some C. acnes isolates required a higher chlorhexidine digluconate MBCs (minimum bactericidal concentrations) than the concentration used in commercial preparations (2%). On the other hand, MBCs determined in the same study for iodine-povidone, ethanol, and benzalkonium chloride were lower than their commercial concentrations [ 116 ].…”

Section: Skin Disinfection and Its Influence On The Microbiome Comentioning

confidence: 99%

Human Skin Microbiome: Impact of Intrinsic and Extrinsic Factors on Skin Microbiota

et al. 2021

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The skin is the largest organ of the human body and it protects the body from the external environment. It has become the topic of interest of researchers from various scientific fields. Microorganisms ensure the proper functioning of the skin. Of great importance, are the mutual relations between such microorganisms and their responses to environmental impacts, as dysbiosis may contribute to serious skin diseases. Molecular methods, used for microorganism identification, allow us to gain a better understanding of the skin microbiome. The presented article contains the latest reports on the skin microbiota in health and disease. The review discusses the relationship between a properly functioning microbiome and the body’s immune system, as well as the impact of internal and external factors on the human skin microbiome.

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“…Ultimately, 79 studies (33)(34)(35)(36)(37) 96)) and povidone-iodine (37,46,49,70,76,91). In total, MBC data from 6218 microbes were extracted.…”

Section: Resultsmentioning

confidence: 99%

“…Articles were published between 1976 and 2021, although the majority (95%) were published this century. The antiseptics used included five different CHX salts (digluconate (33,35,37,40,47,50,(55)(56)(57)(58)61,63,67,69,74,75,81,83,88,90,94,97,99,101,106,107,111,113), gluconate (34,36,42,42,53,91,102,103,108,108,109,112), dichlorohydrate (85)(86)(87), diacetate (71,99) and dihydrochloride( 96)) and povidone-iodine (37,46,49,…”

Section: Study Characteristicsmentioning

confidence: 99%

Bacterial Sensitivity to Chlorhexidine and Povidone-Iodine Antiseptics Over Time: A Systematic Review and Meta-Analysis of Human-Derived Data

Aftab

Dodhia

Jeanes

et al. 2021

Preprint

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BackgroundSurgical site infection (SSI) is the most common complication of surgery, increasing healthcare costs and hospital stay. Topical biocides such as chlorhexidine (CHX) and povidone-iodine (PVI) are used for skin antisepsis to minimise SSIs. There is an increasing concern of developing resistance to topical biocides, however the clinical implications of this remains unclear.OutcomesThe objective of this review was to determine whether the Minimum Bactericidal Concentration (MBC) for topical preparations of CHX or PVI have changed over time, in microbes relevant to SSI.MethodsWe searched for studies which reported the mean bactericidal concentration (MBC) of laboratory and clinical isolates of common SSI causing microbes to CHX and PVI. We excluded samples derived from non-humans and studies using antimicrobial solvents or mixtures of biocides with other active substances. MBC was pooled in random effects meta-analyses and change in MBC over time was explored using meta-regression.Results79 studies were including, analysing 6218 microbes between 1976 and 2021. Most studies used CHX (93%) and there was insufficient data for meta-analysis of PVI. Enterobacteriales had the highest MBC for CHX (20 mg/L [95% CI 14, 25]; I2 95%) whilst MRSA had the lowest (3 mg/L [95% CI 1, 2]; I2 93%). There was no change in MBC of CHX to Staphylococci (β 0.12 [-1.13, 1.37]; I2 99%) or Streptococci (β 0.13 [-0.35, 0.62]; I2 97%).ConclusionsThere is no evidence of change in susceptibility of common SSI-causing microbes to CHX over time. This study provides reassurance that the worldwide guidance that CHX should remain the first-choice agent for skin asepsis prior to surgery.

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Propionibacterium acnes Has Low Susceptibility to Chlorhexidine Digluconate

Abstract: Different skin bacteria have different susceptibilities to disinfectants. To prevent SSIs, the selected disinfectant agent and the disinfection time should have bactericidal activity toward all the bacteria that pose a risk of infection.

Cited by 16 publications

References 13 publications

Evaluation of <i>in Vitro</i> Bactericidal Activity of 1.5% Olanexidine Gluconate, a Novel Biguanide Antiseptic Agent

Evaluation of <i>in Vitro</i> Bactericidal Activity of 1.5% Olanexidine Gluconate, a Novel Biguanide Antiseptic Agent

Human Skin Microbiome: Impact of Intrinsic and Extrinsic Factors on Skin Microbiota

Bacterial Sensitivity to Chlorhexidine and Povidone-Iodine Antiseptics Over Time: A Systematic Review and Meta-Analysis of Human-Derived Data

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