Idade dos ratos versus idade humana: qual é a relação?

Abstract

HEADINGS -Rats. Experimental surgery. Physiology.RESUMO -Racional -Milhões de ratos são empregados anualmente em pesquisas e no ensino. A exata relação entre a idade dos ratos, comparada com a idade dos humanos ainda é assunto de discussão e controvérsias. Objetivo -É revisar a literatura, analisando a idade dos ratos em comparação com a idade dos homens. Métodos -Foram revisadas as publicações existentes sobre o assunto contidas nas bases Medline/Pubmed, Scielo, Biblioteca Cochrane e Lilacs cruzando os descritores ratos, cirurgia experimental e fisiologia. Resultados -Ratos desenvolvem rapidamente durante a infância e se tornam sexualmente maduros com cerca de seis semanas de idade, mas atingem a maturidade social cinco a seis meses mais tarde. Na idade adulta, a cada mês do animal é aproximadamente equivalente a 2,5 anos humanos. Vários autores realizaram trabalhos experimentais em ratos e afirmaram existir Correspondence de 30 dias de vida do homem para cada dia de vida do rato. Conclusão -As diferenças na anatomia, fisiologia, desenvolvimento e fenômenos biológicos devem ser levados em consideração quando são analisados os resultados de qualquer pesquisa em ratos em que a idade é um fator crucial. Cuidado especial é necessário ser tomado quando os estudos efetuados pretendem produzir correlação com a vida humana. Para isso, atenção especial é necessária para verificar a fase em dias do animal e sua correlação com os anos em humanos. ABCDDV/836ABSTRACT -Background -Millions of mice are used annually in research and teaching. The exact relationship between age of the animals compared with the age of humans is still subject to discussion and controversy. Objective -Literature review analyzing the age of rats in comparison with men age. Methods -Were reviewed the existing publications on the subject contained in Medline / Pubmed, Scielo, The Cochrane Database of Systematic Reviews and Lilacs crossing the headings rats, experimental surgery and physiology. Results -Rats rapidly develop during childhood and become sexually mature at about six weeks old, but reach social maturity five to six months later. In adulthood, every month of the animal is approximately equivalent to 2.5 human years. Several authors performed experimental studies in rats and estimated 30 days of human life for every day life of the animal. Conclusion -The differences in anatomy, physiology, development and biological phenomena must be taken into consideration when analyzing the results of any research in rats when age is a crucial factor. Special care is necessary to be taken when the intention is to produce correlation with human life. For this, special attention is needed to verify the phase in days of the animal and its correlation with age in years of humans

Carcinogenesis in rats subjected to a new model ureterosigmoidostomy and treated with L-lysine

“…It should be noted that the time of observation in our study was 30 weeks the equivalent of 7.5 months. In adulthood, every month of the animal is approximately equivalent to 2.5 human years 17 . Therefore, our animals would have a surgery time of about 19 years in humans.…”

Experimental models of renal dysfunction in female rats. Functional and histological aspects after unilateral nephrectomy or ligation of right renal vein with kidney preservation

“…In group 2, right nephrectomy was performed and, in the third group, the right renal vein was occluded with 6-0 nylon suture nearby the renal hilum, preserving the ureter and the renal artery. The fifteen rats were reoperated after seven days, since the life cycle of the rat allows the observation of early alterations 14 ( Figure 1). …”

Old Dog, New Tricks: The Attentional Set-Shifting Test as a Novel Cognitive Behavioral Task after Controlled Cortical Impact Injury

“…23 The time interval between head trauma and EF assessment in these studies is comparable to the one implemented in the current study (i.e., 4 weeks postinjury), considering that, during adulthood, each rat month is approximately equivalent to 2.5 human years. 62,63 All rats in the control groups successfully completed training and testing procedures, whereas in groups subjected to injury, 2 rats were eliminated because they did not complete training and 3 more did not complete the behavioral test procedure (1 in the TBI [2.6 mm] group, 2 in the TBI [2.8 mm] group, and 2 more in the TBI [3.0 mm] group). Though this attrition rate, even at its highest (18.18%), does not surpass previously published drop-out percentages in the AST, 20,38 it may create a selection bias that could ultimately lead to an underestimation of injury effects on cognitive performance, particularly for the TBI (3.0 mm) group.…”