Immune Modulatory Potential of Anti-idiotype Antibodies as a Surrogate of Foot-and-Mouth Disease Virus Antigen

Ahsan, Naveed; Rahman, Sajjad Ur; Arshad, Muhammad; Aslam, Bilal

doi:10.1128/msphere.00522-18

Cited by 9 publications

(8 citation statements)

References 29 publications

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“…This allows stimulation of a broader determinate targeting antibody response that might include epitope spreading. Finally, anti-Ids can be persistent in inducing an immune response against antigens while avoiding autoimmune responses triggered by nominal antigen based vaccines (6).…”

Section: Introductionmentioning

confidence: 99%

The Promise of Anti-idiotype Revisited

Köhler¹,

Pashov²,

Kieber‐Emmons³

2019

Front. Immunol.

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The promise of idiotype-based therapeutics has been disappointing forcing a new look at the concept and its potential to generate an effective approach for immunotherapy. Here, the idiotype network theory is revisited with regard to the development of efficacious anti-idiotype vaccines. The experience of polyclonal anti-Idiotype reagents in animal models as well as an understanding of the immune response in humans lends to the proposition that polyclonal anti-Idiotype vaccines will be more effective compared to monoclonal-based anti-Idiotype vaccines. This novel strategy can be adapted in Biotech-standard production of therapeutic antibodies.

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Section: Introductionmentioning

confidence: 99%

The Promise of Anti-idiotype Revisited

Köhler¹,

Pashov²,

Kieber‐Emmons³

2019

Front. Immunol.

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“…Moreover, because of its phylogenetic distance and structural molecular features, IgY is more suitable for treatment and diagnostic purposes than mammals because of its lack of reactivity with the human complement system and B cell repertoire [1]. However, IgY has a greater avidity for conserved mammalian polypeptides [18,19]. The main antibody (IgY) present in avian blood is transmitted to the offspring and stored in egg yolks, facilitating the non-invasive harvesting of many antibodies [20,21].…”

Section: Resultsmentioning

confidence: 99%

In vivoadministration of anti-HIV hyper-immune eggs induces anti-anti-idiotypic antibodies against HIV gp120 peptides (fragments 308-331 and 421-438) and against HIV gp41 peptide (fragment 579-601) which have demonstrable protective capacity

Justiz-Vaillant

Ferrer-Cosme²,

et al. 2021

Preprint

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Isolation of antibodies from the egg yolk of chickens is of particular interest as a source of specific antibodies for oral administration to prevent infections and use them as immunodiagnostic reagents. The use of birds in antibody production results in a reduction in the use of laboratory animals. Immunized chickens produce larger quantities of antibodies (2000 mg IgY/month) than rodents (200 mg IgG/month) in the laboratory. According to Jerne’s network theory, it is possible to produce an antibody against the antigen-binding site of another antibody. This study assessed the hypothesis that immunization with viral peptides (immunogens) could provide a potent immune response that could be evaluated in chicken eggs. Human immunodeficiency virus 1(HIV-1) is used as an immunogen. The second hypothesis was that an orally administered antibody stimulates the production of a complementary antibody, the so-called anti-idiotypic antibody, which can potentially be therapeutical. This study reports and analyzes the use of eggs as therapeutic agents. We wanted to test the hypothesis that feeding chicks with hyperimmune eggs stimulates the production of anti-anti-idiotypic antibodies that neutralize the original HIV antigen fragments 308-331 or 421-438 of gp120 or fragment 579-601 of gp41. Future research could entail an anti-idiotype strategy for prophylactic vaccines. It is vital to note that it may need an anti-idiotype response to prime immunity against an HIV viral epitope, which may be used as a secondary element. The use of anti-idiotype immune responses in infected individuals may shift the balance of the immune system, allowing the organism to manage HIV infection. Therefore, it may be an avenue for immunotherapy to improve the fight against HIV infections. However, more studies and clinical trials are required to demonstrate similar human immune responses as observed in birds.

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“…Moreover, due to phylogenetic distance and structural molecular features, IgY is more suitable for treatment and diagnostic purposes than mammalian due to lack of reactivity with human complement system and B cell repertoire [1]. However, IgY displays greater avidity for mammalian conserved polypeptides [15,16]. Indeed, chicken IgY antibodies can be used therapeutically and diagnostically; for example, in the diagnosis of viruses, bacteria, and fungi [19–20]; and the treatment of infectious diseases in both animals and humans [21, 22].…”

Section: Resultsmentioning

confidence: 99%

Immunogenicity studies of various experimental vaccines in chickens

Vaillant¹,

Akpaka²

2020

Preprint

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In this paper, the main objective was to raise chickens’ antibodies against three crucial public health microorganisms: the human immunodeficiency virus-1, Salmonella spp, and Staphylococcus aureus. Immunogens were prepared from the said microorganisms. Chickens were vaccinated either orally or intramuscularly. After a booster immunization, mostly eggs were collected and assess for the presence of specific antibodies. The most important results were the production of a large amount of anti-HIV antibodies in chicken’s eggs, and also the synthesis of anti-protein A antibodies with the ability to inhibit the growth of S. aureus in vitro and to serve as anti-anti-idiotypic antibodies with the capacity of neutralizing the original antigen. Enzyme-linked immune absorbent assays detected the presence of these antibodies as anti-Salmonella antibodies that were critical in reducing the bacterial load in the stomach and caeca compared with a control group. The vaccines were effective and safe, but more laboratory work, and economics have to be carried out to start a human trial.

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Immune Modulatory Potential of Anti-idiotype Antibodies as a Surrogate of Foot-and-Mouth Disease Virus Antigen

Cited by 9 publications

References 29 publications

The Promise of Anti-idiotype Revisited

The Promise of Anti-idiotype Revisited

In vivoadministration of anti-HIV hyper-immune eggs induces anti-anti-idiotypic antibodies against HIV gp120 peptides (fragments 308-331 and 421-438) and against HIV gp41 peptide (fragment 579-601) which have demonstrable protective capacity

Immunogenicity studies of various experimental vaccines in chickens

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