Impaired Postnatal Growth of Infants Prenatally Exposed to Cigarette Smoking

Fenercioğlu, Ayşen Kutan; Tamer, İsmet; Karatekın, Güner; Nuhoğlu, Asiye

doi:10.1620/tjem.218.221

Cited by 29 publications

(34 citation statements)

References 16 publications

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“…In addition, CS exposure can directly affect milk production in dams,36 contributing to the smaller postnatal weight gain in pups of smoking mothers. In another study, infants of smoking mothers showed decreased weight and height as well as growth velocities deficits at 6 months of age 37…”

Section: Discussionmentioning

confidence: 92%

“…In another study, infants of smoking mothers showed decreased weight and height as well as growth velocities deficits at 6 months of age. 37 We have previously reported that during hypoxia, eupneic breathing failed, gasping ensued, and recovery was attenuated in 7 days old rat pups prenatally exposed to CS. Hyperthermia further exaggerated such responses.…”

Section: Discussionmentioning

confidence: 94%

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Prenatal cigarette smoke exposure and postnatal respiratory responses to hypoxia and hypercapnia

Pendlebury

Yusuf

Bano

et al. 2011

Pediatric Pulmonology

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Prenatal cigarette smoke (CS) exposure, in combination with hypoxia and/or hyperthermia can lead to gasping and attenuated recovery from hypoxia in 7 days old rat pups. We studied 95 unanesthetized spontaneously breathing 14 days old rat pups to investigate if the destabilizing effects of increased ambient temperature and prenatal CS exposure on respiratory control observed in 7 days old rats were still evident at day 14. This postnatal age was selected as it is beyond the analogous risk period for SIDS in human. Furthermore, we investigated if the breathing responses to hypercapnia are affected by prenatal CS exposure. Since high ambient (HA) temperature can lead to gasping and aberrant respiratory control, we recorded respiratory patterns at low (24-25°C) and high (29-30°C) ambient temperatures, and under hypoxic or hypercapnic states. No gasping was observed in 14 days old rat pups. During hypoxia, breathing frequency increased in the CS-exposed group under low and HA temperatures. Rectal temperature decreased only in the sham group in response to low ambient temperature hypoxia. At HA temperature, breathing frequency increased in both sham and CS-exposed groups during hypercapnia, however, it remained elevated during washout period only in the sham group. We demonstrate that prenatal CS exposure continues to have profound effects on respiratory and thermoregulatory responses to hypoxia and hypercapnia at day 14. The attenuated respiratory and thermoregulatory responses to acute hypoxia and hypercapnia on day 14 demonstrate a strong interaction between CS exposure, respiratory control, and thermoregulation during postnatal maturation.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 94%

Prenatal cigarette smoke exposure and postnatal respiratory responses to hypoxia and hypercapnia

Pendlebury

Yusuf

Bano

et al. 2011

Pediatric Pulmonology

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“…Moreover, these children have decreased serum antioxidant vitamins (A, C, and E), which can contribute to an oxy-cellular redox imbalance and, consequently, increased lipid peroxidation and protein and DNA damage by free radicals present in cigarette smoke (Yilmaz et al, 2009b). Cigarette smoke exposure during pregnancy is related to reduced birth weight, a higher prevalence of sudden infant death syndrome, and impaired child growth, including decreased body mass, length, and head circumference at 3 months of age (Hegaard et al, 2006; Fenercioglu et al, 2009). When cigarette smoke exposure occurs during lactation, changes in milk composition, such as lower total lipid content during the first 6 months of lactation, are observed.…”

Section: Worldwide Tobacco Consumptionmentioning

confidence: 99%

Obesity and Endocrine Dysfunction Programmed by Maternal Smoking in Pregnancy and Lactation

Lisboa¹,

Oliveira²,

Moura³

2012

Front. Physio.

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Obesity is a global epidemic, and maternal smoking has been shown to be associated with the development of childhood obesity. Overall, approximately 40% of children worldwide are exposed to tobacco smoke at home. It is well known that environmental changes within a critical window of development, such as gestation or lactation, can initiate permanent alterations in metabolism that lead to diseases in adulthood, a phenomenon called programming. It is known that programming is based on epigenetic alterations (changes in DNA methylation, histone acetylation, or small interfering RNA expression) that change the expression pattern of several genes. However, little is known concerning the mechanisms by which smoke exposure in neonatal life programs the adipose tissue and endocrine function. Here, we review several epidemiological and experimental studies that confirm the association between maternal nicotine or tobacco exposure during gestation or lactation and the development of obesity and endocrine dysfunction. For example, a positive correlation was demonstrated in rodents between increased serum leptin in the neonatal period and exposure of the mothers to nicotine during lactation, and the further development of leptin and insulin resistance, and thyroid and adrenal dysfunction, in adulthood in the same offspring. Thus, a smoke-free environment during the lactation period is essential to improving health outcomes in adulthood and reducing the risk for future diseases. An understanding of the pathophysiological mechanisms underlying the effects of smoking on programming can provide new insights into therapeutic strategies for obesity.

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“…During pregnancy, human studies show that smoking can lead to prematurity, low birth weight, impaired child growth, higher infant mortality [32,51] and behavioral changes [68,76]. In rats, it has also been demonstrated an association between smoking pregnancy and behavioral disorders [45].…”

Section: Introductionmentioning

confidence: 99%

Maternal nicotine exposure during lactation alters food preference, anxiety-like behavior and the brain dopaminergic reward system in the adult rat offspring

Pinheiro

Moura

Manhães

et al. 2015

Physiology & Behavior

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Impaired Postnatal Growth of Infants Prenatally Exposed to Cigarette Smoking

Cited by 29 publications

References 16 publications

Prenatal cigarette smoke exposure and postnatal respiratory responses to hypoxia and hypercapnia

Prenatal cigarette smoke exposure and postnatal respiratory responses to hypoxia and hypercapnia

Obesity and Endocrine Dysfunction Programmed by Maternal Smoking in Pregnancy and Lactation

Maternal nicotine exposure during lactation alters food preference, anxiety-like behavior and the brain dopaminergic reward system in the adult rat offspring

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