In vitro digestion of curcuminoid-loaded lipid nanoparticles

Starch-based microspheres for sustained-release of curcumin: Preparation and cytotoxic effect on tumor cells

“…In the first 12 h, about 14% of CUR was released from the microspheres. The CUR cumulative release increased up to 38% by 48 h and then a drop in the concentration up to 20% was observed for 96 h. These data are in agreement with the work of Noack et al that investigates the releasing of curcuminoids from loaded lipid nanoparticles (Noack, Oidtmann, Kutza, & Mäder, 2012).…”

“…As the microspheres have high surface area the CUR amount adsorbed is considerable high. The incessant contact between the SGF surface and releasing medium promoted faster dissolution and subsequently CUR was released through desorption process (Noack et al, 2012). For long immersion periods the CUR was released in a sustained manner due to the gradual release of the drug entrapped within the polymeric matrix.…”

“…For long immersion periods the CUR was released in a sustained manner due to the gradual release of the drug entrapped within the polymeric matrix. In addition, the higher release rate in SGF can be attributed to the increased solubility of the CUR under acid conditions when compared with neutral conditions (in SIF, for example) (Kakkar, Singh, Singla, & Kaur, 2011;Noack et al, 2012).…”

Preparation and characterization of nanoemulsions of curcumin and echium oil

“…Bioaccessibility assays revealed that nanoemulsions having high amount of released FFA provided higher bioavailable curcumin. Noack, Oidtmann, Kutza and M€ ader (2012) interpreted that the curcumin release during in vitro digestion was affected by the features of media and lipid carrier. When these studies were taken into consideration, curcumin behaviour during in vitro digestion was concluded to be influenced by characteristics of nanoemulsions, such as lipid type and emulsifier content.…”

In vitro digestion of emulsified lard‐based diacylglycerols

“…17 However, in vivo tests are complex, expensive, and time-consuming. 18 Therefore, to monitor the digestion process, much effort has been devoted to the development of in vitro models. 19 Li et al 17 compared the results of simulated digestion of lipids in vitro with those in vivo and found that there was a good correlation between them.…”