In vitro evaluation of phenolic-enriched maple syrup extracts for inhibition of carbohydrate hydrolyzing enzymes relevant to type 2 diabetes management

Changes in Plasma Glucose in Otsuka Long-Evans Tokushima Fatty Rats After Oral Administration of Maple Syrup

“…The concentration of sucrose, main content of maple syrup, did not differ significantly among the three types of maple syrup data not shown .The obtained results by this study showed that changes in insulin level did not correlate with the reduced enhancement of PG in OLETF rats after the administration of Maple syrup II and Maple syrup III . Apostolidis et al 14 reported previously that maple syrup has in vitro α-glucosidase inhibitory activity, and α-glucosidase in epithelial cells of the small intestine decomposes disaccharides such as sucrose to glucose. Thus, we used the in situ loop technique to investigate glucose absorption from the small intestine into the bloodstream after injections of sucrose or maple syrup.…”

Comparison of the Enhancement of Plasma Glucose Levels in Type 2 Diabetes Otsuka Long-Evans Tokushima Fatty Rats by Oral Administration of Sucrose or Maple Syrup

“…Recently, the results of in vitro studies have suggested that the natural sweetener maple syrup may have antioxidative activity 18 and α-glucosidase inhibitory activity 19 . Therefore, it is possible that maple syrup is suitable for use as a natural sweetener Table 1 Food and water intake of LETO and OLETF rats in this study.…”

“…Apostolidis et al 19 reported that maple syrup has an α-glucosidase inhibitory activity in in vitro. Taken together, the data suggest that the absorption ratio of glucose from maple syrup may be lower than from sucrose in the small intestine, thus preventing the enhancement of PG in maple syrup-administered OLETF rats.…”

“…Once hyperglycemia becomes apparent, β-cell function progressively deteriorates: glucose-induced insulin secretion becomes further impaired and degranulation of β-cells becomes evident, often accompanied by a decrease in the number of β-cells 3 6 . Recently, it was reported that the of maple syrup demonstrated an inhibitory activity toward α-glucosidase 19 . Although, these data suggest the possibility that maple syrup might be used to prevent obesity and the development of diabetes mellitus in comparison with other sweeteners such as sucrose and glucose-fructose syrup, there are almost no reports or scientific evidence to indicate the effects of the oral consumption of maple syrup on plasma glucose PG levels.…”

Antioxidant properties, selected enzyme inhibition capacities, and a cosmetic cream formulation of Thai mango seed kernel extracts

“…The hyaluronidase inhibition activity was determined using sodium hyaluronate as substrate following a previously described method [17]. The α-glucosidase inhibition activity was measured using p-nitrophenyl-α-D-glucopyranoside as substrate [18]. All inhibitory effects of the samples were expressed as the inhibitor concentration causing a 50 % loss of enzyme activity (IC 50 ).…”