2000
DOI: 10.1139/y00-068
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Inhibition of inducible nitric oxide synthesis by the herbal preparation Padma 28 in macrophage cell line

Abstract: Padma 28 is a mixture of herbs used in traditional Tibetan medicine with anti-inflammatory activities. We investigated the effects of Padma 28 on nitric oxide (NO) production by the inducible nitric oxide synthase (iNOS) in lipopolysaccharide stimulated mouse macrophages (RAW 264.7). Padma 28 (0-900 microg/mL) induced a concentration dependent inhibition of inducible nitric oxide synthesis. iNOS protein expression showed a concentration dependent reduction as revealed by immunoblotting when cells were incubate… Show more

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Cited by 37 publications
(12 citation statements)
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(19 reference statements)
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“…Aqueous extract of dried fruit of T. chebula showed anti-inflammatory by inhibiting inducible nitric oxide synthesis [74] . Chebulagic acid from immature seeds of T. chebula significantly suppressed the onset and progression of collagen induced arthritis in mice [75] .…”
Section: Anti-inflammatory and Anti-arthritic Activitymentioning
confidence: 99%
“…Aqueous extract of dried fruit of T. chebula showed anti-inflammatory by inhibiting inducible nitric oxide synthesis [74] . Chebulagic acid from immature seeds of T. chebula significantly suppressed the onset and progression of collagen induced arthritis in mice [75] .…”
Section: Anti-inflammatory and Anti-arthritic Activitymentioning
confidence: 99%
“…In humans, PADMA-28 attenuated the symptoms associated with atherosclerotic patients. [75] Limbrel, a herbal composition of flavonoids, from Scutellaria baicalensis and Acacia catechu was developed as metabolic therapy for osteoarthritis [76] . Flavocoxid, a proprietary blend of natural flavonoid ingredients, was recognized as safe meeting Generally Recognized As Safe (GRAS) status [77] .…”
Section: Cn/anmentioning
confidence: 99%
“…The therapeutic effect of PADMA 28 on experimental allergic encephalomyelitis in SJL/J mice was reported by Badmaev et al (1999). In vitro study performed by Moeslinger et al (2000) have demonstrated inhibition of inducible nitric oxide synthesis by PADMA 28 in mouse macrophage cell line. In the present paper we report for the first time the in vivo stimulatory effect od PADMA 28 on such parameters of cell-mediated immunity in mice as PHA-induced proliferation of splenic lymphocytes and their locomotive ability.…”
Section: Dicsussionmentioning
confidence: 87%
“…Inhibition, in a concentration dependent manner, of inducible nitric oxide synthesis was described by Moeslinger et al (2000). PADMA downregulated iNOS protein and iNOS mRNA level in a macrophage cell line.…”
Section: Dicsussionmentioning
confidence: 97%