Interaction of malonaldehyde with collagen III. Binding site characteristic of malonaldehyde with respect to collagen

Švadlenka, Ivan; Davídková, E.; Rosmus, Jan

doi:10.1007/bf01139539

Cited by 15 publications

(4 citation statements)

References 12 publications

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“…The low activity of SOD in workers of coal handling unit could be due to inactivation of the enzyme by crosslinking or damage to DNA lipid peroxidation and decreased expression of the enzyme. [26] Coal dust concentration was not measured in this study although there was variable amount of dust in different units. Occupational exposure to coal showed a decrease in all the red blood cell antioxidants in some stages of coal workers’ pneumoconiosis.…”

Section: Discussionmentioning

confidence: 95%

Effect of occupation on lipid peroxidation and antioxidant status in coal-fired thermal plant workers

Kaur

Gill

Gupta

et al. 2013

Int J App Basic Med Res

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Background:Air pollution from coal-fired power units is large and varied, and contributes to a significant number of negative environmental and health effects. Reactive oxygen species (ROS) have been implicated in the pathogenesis of coal dust-induced toxicity in coal-fired power plants.Aim:The aim of the study was to measure free radical damage and the antioxidant activity in workers exposed to varying levels of coal dust.Material and Methods:The study population consisted of workers in coal handling unit, turbine unit, and boiler unit (n = 50 each), working in thermal power plant; and electricians (n = 50) from same department were taken as controls. Lipid peroxidation was measured by malondialdehyde (MDA) levels and antioxidant activity was determined by superoxide dismutase (SOD) and glutathione peroxidase (GPx) levels. Statistical analysis was carried out by Student's unpaired t-test.Result:MDA levels showed significant increase (P > 0.001) in the thermal power plant workers than the electricians working in the city. The levels of SOD and GPx were significantly higher (P > 0.001) in electricians as compared to subjects working in thermal plant. Among the thermal plant workers, the coal handling unit workers showed significant increase (P > 0.001) in MDA and significant decrease in SOD and GPx than the workers of boiler and turbine unit workers.Conclusion:Oxidative stress due to increase in lipid peroxidation and decrease in antioxidant activity results from exposure to coal dust and coal combustion products during thermal plant activities.

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Section: Discussionmentioning

confidence: 95%

Effect of occupation on lipid peroxidation and antioxidant status in coal-fired thermal plant workers

Kaur

Gill

Gupta

et al. 2013

Int J App Basic Med Res

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“…Possible reason could be due to utilization of malondialdehyde in crosslinking of collagen. [ 15 16 ] It has been shown by an amino acid analysis that malonaldehyde reacts in a significant way on lysine and tyrosine residues. [ 16 ] Previous studies have revealed fibroblast stimulating properties of malondialdehyde in culture.…”

Section: Discussionmentioning

confidence: 99%

“…[ 15 16 ] It has been shown by an amino acid analysis that malonaldehyde reacts in a significant way on lysine and tyrosine residues. [ 16 ] Previous studies have revealed fibroblast stimulating properties of malondialdehyde in culture. [ 17 ] Addition of MDA to cultured fibroblasts increased collagen production by 2–3 times.…”

Section: Discussionmentioning

confidence: 99%

Malondialdehyde Levels in Oral Sub Mucous Fibrosis: A Clinicopathological and Biochemical Study

et al. 2012

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Background:Oral submucous fibrosis is one of the most commonly occurring potentially malignant disorders in the South-East Asia. Levels of lipid peroxidation product malondialdehyde have been recently correlated with clinical grades of oral Submucous fibrosis.Aims:The aims of this study were to estimate the levels of malondialdehyde in serum, saliva and tissue in patients with oral submucous fibrosis, to correlate change in levels of malodialdehyde with the histopathological grading.Materials and Methods:The study group comprised of 65 clinically diagnosed and histopathologically confirmed cases of oral submucous fibrosis, 21 age and sex matched controls were also enrolled into the study. The serum saliva and tissue samples in the study groups were evaluated by the thiobarbutric acid reactive substances.Results:There was a significant difference between the serum and salivary malondialdehyde among the histopathological grades of oral submucous fibrosis. Tissue malonaldehyde levels were significantly higher as the grading progressed but tissue levels in grade 3 oral submucous fibrosis were lower than the controls.Conclusion:This decrease in tissue malonaldehyde could possibly be associated to collagen cross linking occurring during the advanced stages of oral submucous fibrosis.

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“…The composition of collagen is unique among proteins because it contains a high percentage of hydroxy proline which relegates it to the "pleated-sheet" conformation thereby bringing adjacent fibrils into proximity for the formation of intermolecular bonds (76). The formation of adventitious cross-links is associated with lipid peroxidation (77). The formation of malonaldehyde via lipid peroxidation leads to a reactive intermediate which can form aldimine cross-links between adjacent collagen fibrils.…”

Section: Crosslinking Of Collagenmentioning

confidence: 99%

Biochemical consequences of lipid peroxidation

Bland¹

1978

J. Chem. Educ.

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Biochemical Consequences of Lipid PeroxidationLipid peroxides formed by abberant oxidation reactions of unsaturated lipid material have been identified as important degradative biomolecules involved in the cellular aging process (1), in oxygen toxicity (2), in air pollution oxidant damage to cells (3), and a host of other degenerative biochemical transformations. The mechanism of formation of these lipid peroxides and their biochemical role in observed changes in cellular proteins, enzymes, and nucleotides, lipofusion and ceroid pigment formation, cellular aging, membrane alteration, cross-linking of collagen, and drug/chemical-induced pathologies constitute the focus of this report. The Production and Biochemical Significance of Lipid PeroxidesThe formation of lipid peroxides involves the reaction of biochemical oxidants with polyunsaturated lipids. This process as diagrammed in Figure 1 is most commonly mediated through free radical intermediates (4).Free radical intermediates occur in almost all biological systems (5, 6). The radicals can be produced by three types of processes: 1) thermal homolysis of bonds, 2) one-electron redox reactions, 3) high energy radiation, and photolysis (7). These three processes are illustrated below.

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Interaction of malonaldehyde with collagen III. Binding site characteristic of malonaldehyde with respect to collagen

Cited by 15 publications

References 12 publications

Effect of occupation on lipid peroxidation and antioxidant status in coal-fired thermal plant workers

Effect of occupation on lipid peroxidation and antioxidant status in coal-fired thermal plant workers

Malondialdehyde Levels in Oral Sub Mucous Fibrosis: A Clinicopathological and Biochemical Study

Biochemical consequences of lipid peroxidation

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