Inulin coated plasmonic gold nanoparticles as a tumor-selective tool for cancer therapy

Abstract

Preferential uptake by cancer cells of PEG-inulin coated gold nanoparticles loaded with the drug doxorubicin.

Preparation and Characterization of Inulin Coated Gold Nanoparticles for Selective Delivery of Doxorubicin to Breast Cancer Cells

“…Doxorubicin was selected as anticancer drug widely employed to treat leukemia and Hodgkin's lymphoma, as well as cancers of the bladder, breast, stomach, lung, ovaries, thyroid, soft tissue sarcoma, multiple myeloma, and others [31]. Drug loading was carried out adding aqueous INU-FA and doxorubicin hydrochloride solutions, previously treated with a molar excess of TEA, to the dispersion of Au@citrate [17,20]. The drawing forces that allowed the loading of doxorubicin on Au@INU-FA/Doxo nanoparticles were both physical and chemical interactions.…”

“…Moreover coated GNPs should guarantee a prolonged blood circulation time and provide active functional groups useful to conjugate targeting ligands to GNPs surface. Our group has synthetized many polymeric materials that may be used to coat metallic nanoparticles, including synthetic polyamino acid derivatives [16] and polysaccharides based constructs [17,18]. Among them, inulin, a natural, biocompatible, and biodegradable polysaccharide consisting of linear chains of -(2-1) fructose units that exhibit many hydroxyl functional groups that make inulin versatile and easy to functionalize, has been employed as coating agent for metal NPs and used in several biomedical applications [17][18][19][20][21][22][23][24].…”

Green synthesis, physio-chemical characterization and anti-candidal function of a biocompatible chitosan gold nanocomposite as a promising antifungal therapeutic agent

“…14 AuNPs have been extensively used in drug delivery, intracellular gene regulation, bioimaging (as contrast agents), anti-inammatory and anticancer therapy. 15,16 Furthermore, antimicrobial activity of AuNPs has been recently demonstrated against both bacteria and fungi. 17 C. albicans is currently considered as the fourth and third-leading causative agent of hospital-acquired bloodstream and urinary tract infections, respectively.…”

Microwave Synthesis of Inulin Acetate as Potential Bio-Based Additive for Poly(Vinyl Chloride)

“…The number of studies conducted resulted in the development of environmentally friendly technologies based on the principles of "green chemistry". MW as promising "green technology" for modification of polysaccharides was successfully applied also [18][19][20][21]. The advantages of microwave-assisted chemistry include high efficiency, improvement of reproducibility of the chemical process, reduction of the unwanted side © 2018 Tech Science Press reactions and increase in the purity of the final products.…”

“…The application of the inulin derivatives, and especially its esters, is constantly expanding. The amphiphilic inulin based copolymer was reported to be used for systemic anticancer drug delivery [18]. Application of inulin acetates as encapsulating agent of lipophilic material (as α-tocopherol), drug carrier, antimicrobial agents or vaccine adjuvant constantly increased [22][23][24][25][26][27][28].…”