Lignan profile of Piper cubeba, an Indonesian medicinal plant

Elfahmi, Elfahmi; Ruslan, Komar; Batterman, S.; Bos, Rein; Kayser, Oliver; Woerdenbag, Herman J.; Quax, Wim J.

doi:10.1016/j.bse.2007.01.003

Cited by 37 publications

(32 citation statements)

References 16 publications

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“…These compositions were similar to the ones of other extraction methods like n-Hexane solvent extraction which the main composition was in group of cubebin compound [5] and also extraction under sonification using MeOH [2].…”

Section: Resultssupporting

confidence: 59%

“…cubeba essential oil is one of isolated essential oils from piperaceae family, members of traditional plant in many tropical and subtropical regions like Asia, African, Brazillian [1]- [4]. The chemical composition of P. cubeba oil is alkaloid, amides, terpenoid, benzoic acids, furanofuran, chormenes, chalcones, lignan (cubebin, hinokinin, yatein, isoyatein), and neolignan (kadsurin and piperenone) [1]- [2], [4]- [5]. The chemicals in P. cubeba oil can be used as spices, medicines to treat many ailments (gonorrhea, dysentery, abdominal pain, diarrhea, enteritis), antileishmanial, antimicrobial, antitumoral, fungicidal, and insecticidal [1]- [3], [5]- [5].…”

Section: Introductionmentioning

confidence: 99%

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Extraction of P. Cubeba Essential Oil by Microwave Assisted Hydrodistillation: Modeling and Process Optimization

Sediawan¹,

Handayani²,

Megawati³

2014

AJOCT

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Abstract:The industrial scale equipment design of P. cubeba essential oil extraction by microwave assisted hydro distillation (MAHD), as a relatively new extraction method, requires quantitative description of the mass transfer as well as explorative studies focusing on process optimization. The quantitative modeling was generated by several mathematical diffusion formulas and verified by the experimental mass transfer phenomena, while the optimization of particle-to-water ratio (0.033, 0.05, and 0.067 w/w) and times (0-52 min) was conducted by Response Surface Methodology (RSM). The results showed that the proposed mathematical model based on unsteady-state intraparticle diffusion theories well describes the rate of extraction of P. cubeba essential oil using MAHD method. The particle-to-water ratio as well as the extraction time significantly influences the oil yield. The optimum values obtained were 0.05 w/v and 32 min for particle-to-water ratio and time respectively, while the produced oil yield was theoretically 57.89%.

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Section: Resultssupporting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Extraction of P. Cubeba Essential Oil by Microwave Assisted Hydrodistillation: Modeling and Process Optimization

Sediawan¹,

Handayani²,

Megawati³

2014

AJOCT

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“…Abizar & Prijono (2010) juga melaporkan ekstrak buah P. cubeba memiliki aktivitas insektisida yang kuat terhadap larva C. pavonana instar ke-2, akan tetapi lebih disarankan dicampur dengan ekstrak daun Tephrosia vogelii bunga ungu dalam penggunaannya. Buah P. cubeba mengandung gugus metil endioksifenil seperti kubebin, klusin, dihidroklusin, yatein, hinokinin, dan dihidrokubebin (Elfahmi et al, 2007;Usia, Wabate, Kadota, & Tezuka, 2005). Dalam penelitian ini belum diperoleh fraksi padatan yang aktif seperti yang dilaporkan oleh Nugroho (2008) dan Abizar & Prijono (2010).…”

Section: Bahan Dan Metodeunclassified

Aktivitas Insektisida Ekstrak Piperaceae terhadap Helopeltis antonii pada Kakao

Indriati

Samsudin

2014

JTIDP

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ABSTRAKHelopeltis antonii merupakan hama pucuk dan buah kakao. Pengendalian menggunakan insektisida kimia cukup efektif untuk mengendalikan hama ini, akan tetapi dapat menimbulkan efek negatif pada lingkungan. Oleh sebab itu, pengendalian menggunakan insektisida yang berasal dari tumbuhan dapat menjadi alternatif yang lebih aman. Penelitian bertujuan mengevaluasi aktivitas insektisida dari ekstrak empat jenis tumbuhan dari famili Piperaceae, yaitu Piper aduncum, P. retrofractum, P. cubeba, dan P. sarmentosum, terhadap H. antonii pada kakao. Penelitian dilaksanakan di Laboratorium Proteksi Tanaman Balai Penelitian Tanaman Industri dan Penyegar (Balittri) Sukabumi pada bulan Januari sampai November 2013. Setiap jenis ekstrak diuji pada taraf konsentrasi 1%; 0,5%; 0,25%; 0,125%; 0,062%; dan kontrol (campuran aseton, methanol, dan Tween-80 dengan perbandingan 5:5:2) sebanyak 1,2%. Masing-masing perlakuan diulang sebanyak 3 kali. Uji toksisitas menggunakan imago H. antonii dengan metode penyemprotan serangga uji. Hasil penelitian menunjukkan bahwa ekstrak etil asetat buah P. retrofractum pada konsentrasi 0,25% menyebabkan kematian imago sebesar 83,33% pada 120 jam setelah perlakuan (JSP), sedangkan ekstrak etil asetat P. aduncum, P. cubeba, dan P. sarmentosum pada konsentrasi dan waktu yang sama hanya menyebabkan kematian berturut-turut 33,33%; 20%; dan 13,33%. Aktivitas insektisida dari ekstrak etil asetat buah P. retrofractum paling kuat terhadap imago H. antonii karena mengandung senyawa piperin, yaitu 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-2,4-pentadienoyl] piperidine; (E,E) 1,3-benzodioxol-5-yl-1-oxo-2,4-pentadienylpiperidine; dan 3-benzodioxol-5-yl-1-oxo-2,4-pentadienyl-piperine. LC 95 ekstrak etil asetat buah P. retrofractum terhadap imago H. antonii dibawah 0,5% sehingga paling berpotensi untuk dikembangkan menjadi insektisida nabati pengendali hama tersebut pada kakao. [(2E, 4E)-5 (1,3-benzodioxol-5-yl)-2,4-pentadienoyl] piperidine; (E,E) 1, of P. retrofractum ethyl acetate extract against imago of H. antonii was below 0.5%, so it become the most potential to develop into botanical insecticide.

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“…Dentre as muitas pimentas de uso como condimento está a Piper cubeba (P. cubeba) de origem Asiática que além do seu aroma também é utilizada na medicina popular para o tratamento de dores abdominais, asma, diarreia, enterites, gonorreia e infeção urinária (Elfahmi et al 2007). Inú-meros estudos sobre as propriedades biológicas da P. cubeba e de seus metabólitos secundários já foram descritos na literatura incluindo a atividade antimicrobiana (Silva et al 2005, Khan & Siddiqui 2007, Silva et al 2009, Rukayadi et al 2013.…”

Section: Introductionunclassified

Parâmetros sanguíneos de frangos de corte alimentados com dietas suplementadas com sementes secas de Piper cubeba como aditivo fitogênico

et al. 2016

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RESUMO: Dois experimentos foram realizados com o objetivo de avaliar o uso das sementes secas de Piper cubeba nas dietas de frangos de corte de 1 a 21 dias de idades e seus efeitos sobre o perfil bioquímicos do sangue e na biometria dos órgãos das aves. Em cada experimento 240 pintos de corte machos, com um dia de idade da linhagem Cobb foram distribuídos em um delineamento inteiramente casualizado, com cinco tratamentos e quatro repetições de 12 aves por parcela experimental. No primeiro experimento foi avaliado o uso da Piper cubeba em dietas consideradas de alta digestibilidade, a base de milho e farelo de soja, e no segundo avaliou-se o uso da pimenta em dietas de baixa digestibilidade, as quais foram obtidas com a inclusão de farinha de carne e ossos. Com relação aos dados de perfil bioquímico sanguíneo do experimento I, com exceção da gama glutamil transferase, todos os demais níveis séricos se apresentaram dentro dos limites recomendados para aves, e apenas os níveis de triglicerídeos diferiram entre os tratamentos (P<0,05). No experimento II houve diferença significativa para os níveis de albumina, colesterol e ácido úrico, porém isso não foi resultado de desordens metabólicas, visto que com exceção da gama glutamil transferase, todos os níveis encontraram-se dentro dos limites recomendados. Em ambos os experimentos não foram observadas diferenças (P>0,05) para a biometria dos órgãos. Nas condições em que os experimentos foram realizados a inclusão das sementes de Piper cubeba na ração para frangos de corte não proporcionou alterações bioquímicas e biométricas que possam limitar seu uso como material vegetal para os estudos fitogênicos.

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Lignan profile of Piper cubeba, an Indonesian medicinal plant

Cited by 37 publications

References 16 publications

Extraction of P. Cubeba Essential Oil by Microwave Assisted Hydrodistillation: Modeling and Process Optimization

Extraction of P. Cubeba Essential Oil by Microwave Assisted Hydrodistillation: Modeling and Process Optimization

Aktivitas Insektisida Ekstrak Piperaceae terhadap Helopeltis antonii pada Kakao

Parâmetros sanguíneos de frangos de corte alimentados com dietas suplementadas com sementes secas de Piper cubeba como aditivo fitogênico

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