Low-intensity pulsed ultrasound enhances antibiotic release of gentamicin-loaded, self-setting calcium phosphate cement

Shi, Mude; Chen, Lei; Wang, Yangxin; Yan, Shigui

doi:10.1177/0300060518773023

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…A peculiar work from 2018 by Shi et al [ 112 ] reported on the results obtained by influencing the release of gentamicin from a CPC by means of the use of a low-intensity pulsed ultrasound (LIPUS). Here, the authors explored conditions that are more related to the fluid dynamics rather than to the chemical characteristics of the release medium itself.…”

Section: Release Mediummentioning

confidence: 99%

Factors influencing the drug release from calcium phosphate cements

Fosca

Rau

Uskoković³

2022

Bioactive Materials

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Thanks to their biocompatibility, biodegradability, injectability and self-setting properties, calcium phosphate cements (CPCs) have been the most economical and effective biomaterials of choice for use as bone void fillers. They have also been extensively used as drug delivery carriers owing to their ability to provide for a steady release of various organic molecules aiding the regeneration of defective bone, including primarily antibiotics and growth factors. This review provides a systematic compilation of studies that reported on the controlled release of drugs from CPCs in the last 25 years. The chemical, compositional and microstructural characteristics of these systems through which the control of the release rates and mechanisms could be achieved have been discussed. In doing so, the effects of (i) the chemistry of the matrix, (ii) porosity, (iii) additives, (iv) drug types, (v) drug concentrations, (vi) drug loading methods and (vii) release media have been distinguished and discussed individually. Kinetic specificities of in vivo release of drugs from CPCs have been reviewed, too. Understanding the kinetic and mechanistic correlations between the CPC properties and the drug release is a prerequisite for the design of bone void fillers with drug release profiles precisely tailored to the application area and the clinical picture. The goal of this review has been to shed light on these fundamental correlations.

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Section: Release Mediummentioning

confidence: 99%

Factors influencing the drug release from calcium phosphate cements

Fosca

Rau

Uskoković³

2022

Bioactive Materials

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“…Recently, Shi et al demonstrated that sonication enhanced and prolonged the release of high concentrations of vancomycin and gentamicin from calcium phosphate cement, which serves as a basis for bone cement used to fill bone defects. [88,89] It was suggested that the improved release of antibiotics from bone cement is caused by microstreams arising from stable cavitation and US thermal effects. The USinduced antibiotic release from a bone implant is accompanied by other well-known effects of ultrasonic treatment, including the direct destruction of bacteria, an increase in antibacterial drug activity, and an increase in tissue permeability for antibiotics.…”

Section: Release Of Antibiotics From Implanted Materialsmentioning

confidence: 99%

“…Thus, US can enhance the bactericidal effect of immobilized antibiotics in two ways: by increasing their antibacterial activity and by enhancing and prolonging their release from the implants. [87][88][89] However, some adverse effects of US should be taken into account. Cavitation phenomena, which are necessary to stimulate drug release from the carrier or drug transport into cells, can be harmful to the tissues.…”

Section: Release Of Antibiotics From Implanted Materialsmentioning

confidence: 99%

Different Aspects of Using Ultrasound to Combat Microorganisms

Nakonechny

Nisnevitch

2021

Adv Funct Materials

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Growing resistance of microorganisms to antibiotics due to their widespread use has led to multiple bacterial infections posing a serious threat to health and human life. Low-frequency ultrasound is one of physical methods for inactivation of pathogenic microbial cells. Application of ultrasound is safe, demonstrates good tissue penetration without significant attenuation of energy, and does not induce microbial resistance. Bactericidal effect of ultrasound is based on acoustic cavitation-the growth and collapse of microbubbles in a liquid medium, resulting in shock waves, shear forces, and microjets which cause irreversible damage and inactivation of microorganisms. The present review combines and analyzes literature data on in vitro and in vivo studies and summarizes works demonstrating the ability of ultrasound, alone or in combination with other methods, to combat pathogenic microorganisms. The results of various studies presented in this review show that low-frequency ultrasound has a noticeable antimicrobial effect on planktonic cells of microorganisms and biofilms. Ultrasound synergistically enhances the effectiveness of other antibacterial agents and activates molecules called sonosensitizers, resulting in the formation of compounds toxic to microbial cells. Ultrasound can also promote local release of antimicrobial drugs from liposomes, as well as from medical implants.

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