Markers of Atopic Reactivity in the Pupils With Severe Bronchial Asthma

Колоскова, Е К; Bezrukov, L.O.; Marusyk, U.I.; Lobanova, T. O.; Burenyuk, Christina

doi:10.21303/2504-5679.2016.00072

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…It induces the production of IgE and expression of major histocompatibility complex class-II molecules, B7, CD40, and surface IgM on B cells, thereby enhancing their antigen-presenting capacity (14). It is the key cytokine involved in the pathogenesis of allergic diseases (16) and is implicated in airway remodeling and stimulation of mucus-producing cells (17). Its overexpression in the lungs induces eosinophilic inflammation without airway hyperreactivity (18); Therefore, demonstrating its involvement in asthma had been difficult.…”

Section: Il-4mentioning

confidence: 99%

Role of Cytokines and Chemokines in the Outcome of Children With Severe Asthma

Hatami

Ghaffari

et al. 2018

JPR

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Context: Asthma, characterized by airway inflammation, is a common chronic disease of childhood. Cytokines and chemokines could be used in the diagnosis, treatment, and management of asthma severity in children. In this review, we have explained the application of cytokines and chemokines as biomarkers in pediatric asthma. Evidence Acquisition: All related articles were separately searched by two researchers using the following keywords in PubMed, Scopus, and Embase databases: Cytokine biomarkers, chemokines biomarkers, and children asthma. Articles published from 2000 to 2017 were investigated in the research, and 28 articles were included in the final analysis for this review. Results: About cytokines, serum Interleukin 4 (IL-4) level is a marker of the presence of asthma, and IL-13 is a key cytokine involved in the manifestation of asthma symptoms. High IL-13 concentration and number of IL-13+ cells in the bronchial submucosa specimens are characteristic of severe asthma. Serum IL-5 concentration 3.1 times in children with severe asthma. IL-17 is involved in airway obstruction. IFN-γ gene polymorphism (+874A/T) in children elevates susceptibility to asthma. TGFB1 polymorphisms are considered as indicators of asthma severity. IL-26 plays an important role in asthma severity. IP-10 may be a useful inflammatory marker of asthma severity. High periostin level has been identified in pediatric asthma. PDGF level, which is high in asthma patients, plays an important role in bronchial fibrosis. About chemokines, plasma TARC concentration may be a useful biomarker of airway inflammation and asthma severity in children. Studies have supported the association between high serum RANTES levels and severe airway obstruction in children. CXCR4 levels are high in pediatric asthma and are associated with disease severity. Conclusions: A wide range of cytokines and chemokines may play important roles in asthma severity in pediatric patients. Therefore, several studies have recommended the use of multiple molecular biomarkers, such as cytokines, for determining asthma severity in children.

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Section: Il-4mentioning

confidence: 99%

Role of Cytokines and Chemokines in the Outcome of Children With Severe Asthma

Hatami

Ghaffari

et al. 2018

JPR

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Inflammatory markers in exhaled breath condensate in bronchial asthma

2021

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Chronic respiratory diseases are among the most common non- infection diseases. In particular, it is bronchial asthma (BA), characterized by bronchial hyperreactivity and varying degrees of airway obstruction that is the cause of morbidity and mortality. The methods available for the information about the presence of inflammation in the airways, such as bronchoscopy and bronchial biopsy to be obtained have currently been invasive and difficult in everyday clinical practice, especially for children and seriously ill patients. In this regard, recently there has been an increase in the development of non-invasive methods for diagnosing the respiratory system, being comfortable and painless for trial subjects, especially children, also providing the inflammatory process control in the lungs, the severity assessment and monitoring the treatment process. The exhaled breath condensate (EBC) is of great attention, which is a source of various biomolecules, including nitric oxide (NO), leukotrienes, 8-isoprostane, prostaglandins, etc., being locally or systemically associated with disease processes in the body. Of particular interest is the presence of cytokines in EBC, namely the specific proteins produced by various cells of the body that play a key role in inflammatory processes in AD and provide cell communication (cytokine network). Thereby, it becomes possible for the severity and control level of childhood bronchial asthma using only the EBC analysis to be assessed. In addition, the non-invasiveness of this method allows it to be reused for monitoring lung diseases of even the smallest patients, including infants. Thus, the field of metabolite analysis in EBC has been developing and, in the near future, the given method is likely to be the most common for diagnosing the respiratory system diseases in both children and adults.

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Markers of Atopic Reactivity in the Pupils With Severe Bronchial Asthma

Cited by 2 publications

References 16 publications

Role of Cytokines and Chemokines in the Outcome of Children With Severe Asthma

Role of Cytokines and Chemokines in the Outcome of Children With Severe Asthma

Inflammatory markers in exhaled breath condensate in bronchial asthma

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