Mass spectrometry profiling reveals altered plasma levels of monohydroxy fatty acids and related lipids in healthy humans after controlled exposure to biodiesel exhaust

Chronic exposure to traffic-related air pollution reduces lipid mediators of linoleic acid and soluble epoxide hydrolase in serum of female rats

“…Mice exposed to ultrafine particle components of TRAP for 8 weeks showed increased plasma, liver and intestinal LA-and AA-derived hydroxylated and prostanoid lipid mediators of 5-LOX and COX1/2, respectively, compared to mice exposed to filtered air (FA) (Li et al, 2015). Similar findings were reported in human plasma and lung lavage following acute diesel exposure (Gouveia-Figueira et al, 2017;Gouveia-Figueira et al, 2018). A recent observational study in humans showed that exposure to elevated TRAP over a 3-day period was associated J o u r n a l P r e -p r o o f 7 with higher serum concentrations of hydroxylated LOX metabolites of AA, increased sEHderived diols of AA, and reduced COX-derived prostanoids of AA (Wang et al, 2021b).…”

“…FA control animals were exposed to background ambient air that was subjected to multiple emission control technologies to remove residual air pollutants as previously described (Edwards et al, 2020). We measured oxylipins (Gouveia-Figueira et al, 2017;Gouveia-Figueira et al, 2018;Li et al, 2015;Wang et al, 2021a).…”

Quenching the fires: Pro-resolving mediators, air pollution, and smoking

“…Increased levels of inflammatory lipid mediators are associated with the inhalation of air pollution. Oxylipins that promote airway inflammation, including 12,13-DiHOME, 9-HODE, 5-HETE, and 13-HODE, are increased in the plasma and bronchoalveolar lavage (BAL) fluid of adults up to 24 hours after an acute exposure to biodiesel exhaust or subway air (Gouveia-Figueira, et al, 2017;Gouveia-Figueira, et al, 2018;Lundstrom, et al, 2011). 8-isoprostane, an indicator of oxidative stress that is derived from arachidonic acid, is increased in people exposed to air pollutants.…”

Quantification of Eicosanoids and Their Metabolites in Biological Matrices: A Review

“…A study was conducted to detect circulating bioactive lipid metabolites alterations in response to biodiesel exhaust exposure using LC-MS/MS, with major emphasis on inflammation causing metabolites and effects on cardiovascular health. Among the 51 analyzed lipid metabolites, seven monohydroxy lipid metabolites displayed significant responsiveness after 24 h of biodiesel exhaust exposure [68]. Morgenstern et al quantitated 15-deoxy-12,14-prostaglandin J2 (15d-PGJ2) in human plasma samples to understand the anti-inflammatory potential of 15-deoxy-12,14-prostaglandin J2 (15d-PGJ2) in severe long-term proinflammatory disorders like diabetes, cancer, or cardiovascular disease [69].…”