Matrix-Degrading Metalloproteinases in Photoaging

Quan, Taihao; Qin, Zhaoping; Xia, Wei; Shao, Yinlin; Voorhees, John J.; Fisher, Gary J.

doi:10.1038/jidsymp.2009.8

Cited by 608 publications

(566 citation statements)

References 39 publications

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“…One of the mechanisms responsible for increased protein degradation in photoageing results from the activation of proteases such as matrix metalloproteinases (MMPs) [25,51,52]. In particular, human macrophage metalloelastase (MMP12) is the most active protease in elastin degradation and is secreted by several cells including keratinocytes, fibroblasts and inflammatory cells [25,53].…”

Section: Elastin Role On Photoageingmentioning

confidence: 99%

Elastin structure and its involvement in skin photoageing

Weihermann

Lorencini

Brohem

et al. 2016

Intern J of Cosmetic Sci

147

102

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Skin aging is a complex process that may be caused by factors that are intrinsic and extrinsic to the body. Ultraviolet (UV) radiation represents one of the main sources of skin damage over the years and characterizes a process known as photoaging. Among the changes that affect cutaneous tissue with age, the loss of elastic properties caused by changes in elastin production, increased degradation and/or processing produces a substantial impact on tissue esthetics and health. The occurrence of solar elastosis is one of the main markers of cutaneous photoaging and is characterized by disorganized and non-functional deposition of elastic fibers. The occurrence of UV radiation-induced alternative splicing of the elastin gene, which leads to inadequate synthesis of the proteins required for the correct assembly of elastic fibers, is a potential explanation for this phenomenon. Innovative studies have been fundamental for the elucidation of rarely explored photoaging mechanisms and have enabled the identification of effective therapeutic alternatives such as cosmetic products. This review addresses cutaneous photoaging and the changes that affect elastin in this process.R esum e Le vieillissement de la peau est un processus complexe qui peutêtre caus e par des facteurs intrins eques et extrins eques du corps. Les rayons ultraviolets (UV) repr esentent l'une des principales sources de dommages de la peau au fil des ans et caract erise un processus connu sous le nom de photo-vieillissement. Parmi les changements qui affectent le tissu cutan e avec l'âge, la perte des propri et es elastiques caus ees par des changements dans la production d' elastine, augmentation de la d egradation et / ou le traitement, produit un impact important sur l'esth etique et la sant e des tissus. La survenue d'une elastose solaire est l'un des principaux marqueurs de photo-vieillissement cutan e et se caract erise par un d epôt d esordonn e et non-fonctionnel des fibres elastiques. L'apparition d'un epissage alternatif du g ene de l' elastine induit par le rayonnement UV, ce qui conduit a une synth ese insuffisante des prot eines n ecessaires a l'assemblage correct des fibres elastiques, est une explication possible de ce ph enom ene. Des etudes novatrices ont et e fondamentales pour l' elucidation des m ecanismes de photovieillissement rarement explor es et ont permis l'identification d'alternatives th erapeutiques efficaces, tels que les produits cosm etiques. Cette revue porte sur le photo-vieillissement cutan e et les changements qui affectent l' elastine dans ce processus.

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Section: Elastin Role On Photoageingmentioning

confidence: 99%

Elastin structure and its involvement in skin photoageing

Weihermann

Lorencini

Brohem

et al. 2016

Intern J of Cosmetic Sci

147

102

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“…A single exposure of the skin to UV (2 MED) leads to the inhibition of procollagen synthesis within 24 h, which is followed by an increase in its synthesis after 48-72 h. This phenomenon is also linked with the impairment of the TGF-b pathway. Collagen degradation, on the other hand, mainly results from metalloproteinase activation [1].…”

Section: The Proportion Of the Immunoreactive Cells In Skin Biopsiesmentioning

confidence: 99%

“…In skin exposed to UVR, the disorganization of collagen fibers, deposits of elastin, and decreased amounts of collagen I and III precursors are observed [1]. Matrix metalloproteinases (MMPs) are proteolytic enzymes with the ability to degrade collagen, elastic fibers, and other proteins [2].…”

Section: Introductionmentioning

confidence: 99%

One week’s holiday sun exposure induces expression of photoaging biomarkers

Lesiak

Rogowski-Tylman

Danilewicz

et al. 2015

Folia Histochem Cytobiol.

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Introduction. Skin aging is accompanied by the upregulation of the expression of various matrix metalloproteinases (MMPs). It was shown that exposure to ultraviolet radiation (UVR) may induce skin expression of MMPs and dysregulation of the transforming growth factor beta (TGF-b)/Smad pathway. The aim of our study was to compare the effects of short holiday UVR exposure and lifetime UVR exposure, on the expression of MMP-8, TGF-b1, and Smad2 in human skin biopsies. Material and methods. Skin biopsies were taken from the outer upper arm of 15 elderly people with significant photoaging (mean age 64.1 years) (Group 1) and from 15 healthy young adult volunteers (mean age 24.1 y) who participated in a six-day sun holiday. Biopsies were taken twice: 24 hours before leaving for holiday (Group 2a) and 24 hours after returning (Group 2b). The expression of TGF-b1, Smad2, and MMP-8 was examined by immunochemistry and measured semiquantitatively by two independent pathologists. Results. The mean expression of TGF-b1 in dermal fibroblasts and keratinocytes in Group 1 and Group 2b was significantly lower than in Group 2a (0.54% ± 0.44% and 0.48% ± 0.51% vs. 1.48% ± 0.72%, respectively). The percentage of Smad2 (+) cells in Group 1 and Group 2b was lower than in Group 2a (2.13% ± 1.39% and 1.81% ± 1.16% vs. 4.13% ± 1.58%, respectively). The MMP-8 expression in Group 2b was 1.36% ± 0.68% and was significantly higher than in Group 1 (0.34% ± 0.42%) and Group 2a in which the protein was not detected (p < 0.001). Conclusions. We conclude that the decrease in the expression of TGF-b1 and Smad2 is a persistent biomarker of skin photoaging, while the increased expression of MMP-8 in keratinocytes can be regarded as a marker of acute sun exposure.

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“…79, No. 12,[2018][2019][2020][2021] The gelatinolytic activity of MMP-2 in conditioned medium was determined using zymographic analysis as previously described.…”

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confidence: 99%

Antioxidative properties of ginsenoside Ro against UV-B-induced oxidative stress in human dermal fibroblasts

Kang

Lee

et al. 2015

Bioscience, Biotechnology, and Biochemistry

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Ginsenoside Ro (Ro), an oleanolic acid-type ginsenoside, exhibited suppressive activities on reactive oxygen species (ROS) and matrix metalloproteinase-2 (MMP-2) elevation in UV-B-irradiated fibroblasts. Ro could overcome the reduction of the total glutathione (GSH) contents in UV-B-irradiated fibroblasts. Ro could not interfere with cell viabilities in UV-B-irradiated fibroblasts. Collectively, Ro possesses a potential skin anti-photoaging property against UV-B radiation in fibroblasts.

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Matrix-Degrading Metalloproteinases in Photoaging

Cited by 608 publications

References 39 publications

Elastin structure and its involvement in skin photoageing

Elastin structure and its involvement in skin photoageing

One week’s holiday sun exposure induces expression of photoaging biomarkers

Antioxidative properties of ginsenoside Ro against UV-B-induced oxidative stress in human dermal fibroblasts

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