Mean platelet and red blood cell volume measurements to estimate the severity of hypertension in pregnancy

Piazze, Juan; Gioia, Stefano; Maranghi, Luca; Anceschi, Maurizio M.

doi:10.1515/jpm.2006.044

Cited by 30 publications

(38 citation statements)

References 4 publications

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“…Previous studies have shown higher MPV levels in non-pregnant Type II diabetic patients, as compared to the general population (Jirapinyo et al, 1993;Piazze et al, 2006). The risk factors and development of GDM appear to be similar to those of Type II DM.…”

Section: Discussionmentioning

confidence: 64%

Mean platelet volume in diagnosis of gestational diabetes

Çelikel¹,

Kurt²,

Töz³

et al. 2014

jecm

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Section: Discussionmentioning

confidence: 64%

Mean platelet volume in diagnosis of gestational diabetes

Çelikel¹,

Kurt²,

Töz³

et al. 2014

jecm

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“…Another interesting finding was the negative correlation between MPV and plasma lipid levels, which is considered a major cardiovascular risk factor. Although several studies have previously shown the association between MPV and hypertension, 14,15,21,22 its relationship in subjects without hypertension is unknown. The latest studies have shown that prehypertension causes platelet activation, as demonstrated by increased MPV.…”

Section: Discussionmentioning

confidence: 98%

Increased platelet volume in a general population with prehypertension: a cross-sectional study of 80 545 participants from China

et al. 2012

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Mean platelet volume (MPV), an indicator of platelet activation, has been shown to be elevated in patients with hypertension. However, data available on the association between MPV level and prehypertension are limited. Prehypertension is also associated with an increase in cardiovascular morbidity and mortality. A cross-sectional study was performed among 80 545 standardized medical checkup participants X18 years in age without hypertension or diabetes in China between April 2009 and May 2010. Blood pressure was categorized as prehypertensive (systolic blood pressure, 120-140 mm Hg and/or diastolic blood pressure, 80 to 90 mm Hg, n ¼ 36 586) and normotensive (systolic blood pressure, o120 mm Hg and diastolic blood pressure, o80 mm Hg, n ¼ 43 959). Mean systolic blood pressure and the prevalence of prehypertension increased significantly with increasing MPV. After adjusting for demographics, body mass index, smoking and serum cholesterol, the odds ratio for prehypertension, when comparing the highest category of MPV (412.0 fl) with the lowest category (o10.1 fl), was 1.08 (95% confidence interval, 1.02-1.13; P for trend ¼ 0.014). This association persisted in separate analysis among men but not among women. In nonparametric models, the positive association between MPV and prehypertension appeared to be present across the full range of MPV, without any threshold effect. Increased MPV is associated with prehypertension in a large sample of Chinese adults that are free of cardiovascular disease and hypertension.

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“…Changes in platelet function are more complex. In normal pregnancies, a small increase in platelet aggregation is observed which is due to increased MPV [6,9,10]. Increased platelets size is reported in the cases of pre-eclampsia [6].…”

Section: Introductionmentioning

confidence: 98%