Mechanical and oxidative stress in osteoarthritis

Yui, Naoko; Yudoh, Kazuo; Fujiya, Hiroto; Musha, Haruki

doi:10.7600/jpfsm.5.81

Cited by 6 publications

(2 citation statements)

References 38 publications

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“…The MDA level was used as an indicator of the lipid peroxidation level and was also associated with an increase in free radical production ( Mas-Bargues et al, 2021 ). In the case of surgically induced knee OA, oxidative stress also increased due to mechanical force ( Yui et al, 2016 ). Also, oxidative stress was associated with an elevated level of obesity due to the presence of immoderate adipose tissue ( Pottie et al, 2006 ).…”

Section: Discussionmentioning

confidence: 99%

Fermented jellyfish (Rhopilema esculentum) collagen enhances antioxidant activity and cartilage protection on surgically induced osteoarthritis in obese rats

Sudirman

Chen

et al. 2023

Front. Pharmacol.

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Collagen has been considered a key treatment option in preventing damage to the articular cartilage over time and supporting the healing process, following the onset of osteoarthritis (OA). This study aimed to investigate the effect of collagen fermented from jellyfish (FJC) by Bacillus subtilis natto on anterior cruciate ligament transection with medial meniscectomy (ACLT + MMx)-induced knee OA in high-fat diet (HFD)-induced obesity in rats. The male Sprague–Dawley rats were fed an HFD for 6 weeks before ACLT + MMx surgery, after which they were administered a daily oral gavage of saline (control, OA, and OBOA), either with FJC (20 mg/kg, 40 mg/kg, and 100 mg/kg body weight) or glucosamine sulfate as a positive control (GS; 200 mg/kg body weight) for 6 weeks. Treatment with FJC decreased the fat weight, triglyceride, and total cholesterol levels in obese rats. Additionally, FJC downregulated the expression of some proinflammatory cytokines, including tumor necrosis factor-α, cyclooxygenase-2, and nitric oxide; suppressed leptin and adiponectin expression; and attenuated cartilage degradation. It also decreased the activities of matrix metalloproteinase (MMP)-1 and MMP-3. These results demonstrated that FJC showed a protective effect on articular cartilage and also suppressed the degradation of cartilage in an animal OA model, suggesting its potential efficacy as a promising candidate for OA treatment.

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Section: Discussionmentioning

confidence: 99%

Fermented jellyfish (Rhopilema esculentum) collagen enhances antioxidant activity and cartilage protection on surgically induced osteoarthritis in obese rats

Sudirman

Chen

et al. 2023

Front. Pharmacol.

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“…It was demonstrated that NO synthesis was actively progressed in OA chondrocytes [25]. In other words, OA chondrocytes might undergo some cellular events like inflammatory response, apoptosis or oxidative stress [26]. Moreover, increased expression of iNOS and NO have been found in vivo in inflammatory, septic arthritis and in patients with rheumatoid arthritis [27].…”

Section: Discussionmentioning

confidence: 99%

Foxo3a aggravates inflammation and induces apoptosis in IL-1-treated rabbit chondrocytes via positively regulating tenascin-c

Wang

Qiu-bin

Zhu

et al. 2020

Folia Histochem Cytobiol.

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Introduction. Osteoarthritis (OA) is the most common degenerative disease in middle-aged and elderly individuals that causes joint deformity and limb disability. Accumulating evidence has suggested that the pathogenesis of OA has been related to various mechanisms such as apoptosis, inflammation, oxidative stress and metabolic disorders. The aim of this study is to clarify the role of Foxo3a in the progress of OA in an in vitro model. Materials and methods. The chondrocytes were derived from rabbit, and treated with IL-1b, which was used as an in vitro OA model. The over-expression and down-regulation of Foxo3a were achieved by transfection with overexpression vector or shRNA, respectively. The mRNA level of iNOS in chondrocytes was quantified by qPCR. Tenascin-c (Tnc) production was measured by ELISA and apoptosis-associated proteins were analyzed by Western blotting. The MTT assay was used to assess the viability of chondrocytes. Results. Foxo3a and iNOS expression were upregulated in IL-1b-treated chondrocytes. Foxo3a silencing decreased iNOS expression, and inhibited apoptosis of IL-1b-treated chondrocytes. The production of Tnc was significantly increased in IL-1b-treated chondrocytes and was positively regulated by Foxo3. Importantly, extracellular addition of Tnc abrogated the protective effects of Foxo3a knockdown on IL-1b -treated chondrocytes. Conclusion. The present study indicated that down-regulation of Foxo3a protected IL-1b-treated chondrocytes by decreasing iNOS expression and suppressing chondrocytes' apoptosis via modulating tenascin-c, which could be regarded as a potent therapeutic target for the treatment of OA.

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Oxidative stress, senescence and Mediterranean diet effects on osteoarthritis

Ammendola¹,

d’Abusco

2020

Aging

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Mechanical and oxidative stress in osteoarthritis

Cited by 6 publications

References 38 publications

Fermented jellyfish (Rhopilema esculentum) collagen enhances antioxidant activity and cartilage protection on surgically induced osteoarthritis in obese rats

Fermented jellyfish (Rhopilema esculentum) collagen enhances antioxidant activity and cartilage protection on surgically induced osteoarthritis in obese rats

Foxo3a aggravates inflammation and induces apoptosis in IL-1-treated rabbit chondrocytes via positively regulating tenascin-c

Oxidative stress, senescence and Mediterranean diet effects on osteoarthritis

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