Mechanism of action vasodilation Annona muricata L. leaves extract mediated vascular smooth muscles

Ismail, Sjarif; Hayati, Nur; Rahmawati, Nuning

doi:10.1088/1755-1315/144/1/012006

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…can lower blood sugar levels. [23][24][25] Majority of the plant remedies in this study were prepared by decoction (40%), then by crushed or pounded (31%), infusion (20%), and concoction (9%) ( Figure 6). Some herbal preparations were taken by mixing with lime paste.…”

Section: Resultsmentioning

confidence: 99%

The Medicinal Plants Used in Anjir Pulang Pisau, Central Kalimantan-Indonesia

Novaryatiin¹,

Indah²

2019

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Background: The use of medicinal plants in Anjir Pulang Pisau Village has been carried out for a long time through knowledge that is passed down through generations to family members. But there is no documentation of local knowledge about medicinal plants. Objective: This study was aimed to investigate the use of medicinal plants in Anjir Pulang Pisau Village, Central Kalimantan-Indonesia. Methods: The data were collected through individual interviews using semi-structured interviews. Information regarding the local names of the plant, medicinal uses, parts used, methods of preparation, and administration route were documented. Results: A total of 28 medicinal plants were identified. The family Anacardiaceae, Lamicaeae, Poaceae, and Myrtaceae had the highest proportion of medicinal plants used (7% each). The most frequently utilized medicinal plant parts were roots (47%). The plant species used to treat the high percentage of disease was Curcuma zedoaria (Christm.) Roscoe. (16%). In terms of frequency of medicinal plant uses, the highest percentage of plant species (21%) was used to treat wound. Majority of the plant remedies in this study were prepared by decoction (40%), and most medicinal plant preparations were taken orally (75%). Conclusion: Further research is needed to identify unidentified family and plant species. Pharmacognostical and pharmacological studies are also needed for the identification of chemical compounds and proving the efficacy of medicinal plants used by local people.

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Section: Resultsmentioning

confidence: 99%

The Medicinal Plants Used in Anjir Pulang Pisau, Central Kalimantan-Indonesia

Novaryatiin¹,

Indah²

2019

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“…Flavonoid (Ismail et al, 2018) menunjukkan efek penghambatan reseptor beta adrenergik (beta blocker) yang dapat menurunkan curah jantung sehingga terjadi penurunan tekanan darah (Clark et al, 2012).…”

Section: Peran Anti-hipertensi Dalam Tubuh Penderita Gambar 1 Mekanis...unclassified

“…Ketika pembuluh darah melebar maka darah lebih mudah mengalir sehingga resistensi perifer atau tekanan yang dibutuhkan darah untuk mengalir ke seluruh tubuh lebih kecil yang menyebabkan penurunan tekanan darah. senyawa bahan yang menunjukkan efek vasodilatasi dengan dua mekanisme yaitu endo-intact yang tergantung pada endotelium dan endo-denuded yang tidak tergantung pada endotelium (Ismail et al, 2018). Senyawa Allicin (Cui et al, 2020), Ginsenoside (Lee et al, 2016) dan antosianin (Sarr et al, 2009) menunjukkan efek vasodilatasi dengan mekanisme endo-intact yang melibatkan Nitrit oksida (NO) (Ismail et al, 2018).…”

Section: Peran Anti-hipertensi Dalam Tubuh Penderita Gambar 1 Mekanis...unclassified

“…senyawa bahan yang menunjukkan efek vasodilatasi dengan dua mekanisme yaitu endo-intact yang tergantung pada endotelium dan endo-denuded yang tidak tergantung pada endotelium (Ismail et al, 2018). Senyawa Allicin (Cui et al, 2020), Ginsenoside (Lee et al, 2016) dan antosianin (Sarr et al, 2009) menunjukkan efek vasodilatasi dengan mekanisme endo-intact yang melibatkan Nitrit oksida (NO) (Ismail et al, 2018). Peningkatan produksi dan pelepasan NO dapat menyebabkan relaksasi sehingga terjadi vasodilatasi (Verma et al, 2021).…”

Section: Peran Anti-hipertensi Dalam Tubuh Penderita Gambar 1 Mekanis...unclassified

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Literatur Review : Peran Anti-Hipertensi dalam Penurunan Tekanan Darah

Arief¹,

Arief²

2022

AlGIZZAI

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Hypertension is a silent killer because many sufferers do not show symptoms before reaching severe conditions and even complications to death. This review article aims to analyze the use of herbal ingredients in the treatment of hypertension. Quercetin and sterols act as anti-hypertension in the RAAS as ACEIs so that angiotensin 1 cannot be converted into angiotensin 2, which has various effects that can increase blood pressure. Flavonoids (beta-blockers) can reduce cardiac output, resulting in blood pressure. Allicin, Ginsenoside, and anthocyanin compounds exhibit vasodilating effects with an endo-intact mechanism involving nitric oxide (NO). Increased production and release of NO can cause relaxation resulting in vasodilation. And the endo-denuded effect on vascular smooth muscle. Angiotensin 2 binds to the AT1 receptor in vascular smooth muscle, and it causes vasoconstriction. This anti-hypertensive is found in Allium sativum, Moringa oleivera, Apium graveolens, Annona muricata, Andrographis paniculata, Alstonia scolaris, Panax ginseng, Phoenix sylvestris, Piper nigrum, and Hibiscus sabdariffa.

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Compensatory depression of arterial pressure and reversal of ECG abnormalities by Annona muricata and Curcuma longa in hypertensive Wistar rats

Oridupa

Oyagbemi

Adejumobi

et al. 2021

Journal of Complementary and Integrative Medicine

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Objectives Increasing hypertension incidence in Sub-Sahara Africa and the current cost of management of the metabolic disorder has necessitated research on medicinal plants employed in African Traditional Medicine for hypertension. Thus, this study evaluated antihypertensive effect of Annona muricata leaves or Curcuma longa rhizomes in experimentally-induced hypertensive male Wistar rats (n=70) which were unilaterally nephrectomized and daily loaded with 1% salt. Cardiovascular and haematological changes, as well as urinalysis were determined. Methods Rats were uninephrectomized and NaCl (1%) included in drinking water for 42 days. Extract-treated hypertensive rats were compared to normotensive, untreated hypertensive and hypertensive rats treated with lisinopril (5 mg/70 kg) or hydrochlorothiazide (12.5 mg/70 kg). A. muricata extract or C. longa extract were administered at 100, 200 or 400 mg/kg. Blood pressure (systolic, diastolic and mean arterial) and electrocardiogram was measured on day 41. Twenty-four-hour urine samples were collected from day 42. Blood samples were collected on day 43 for haematology (PCV, red cell indices, WBC and its differentials, and platelets). Results and Conculsions A. muricata or C. longa extracts caused a decline in elevated blood pressure of hypertensive rats. Heart rate and QT segment reduction coupled with prolonged QRS duration were reversed in extract-treated rats, with significant increases in hemogram parameters indicating increased blood viscosity. Also, leukocyturia, proteinuria and ketonuria with increased urine alkalinity, urobilinogen and specific gravity which are classical indicators of poor prognostic outcomes in hypertension were reversed in extract-treated rats. In conclusion, A. muricata and C. longa have cardioprotective effect with reversal of derangements in haemogram and urinalysis associated with hypertension.

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Mechanism of action vasodilation Annona muricata L. leaves extract mediated vascular smooth muscles

Cited by 4 publications

References 8 publications

The Medicinal Plants Used in Anjir Pulang Pisau, Central Kalimantan-Indonesia

The Medicinal Plants Used in Anjir Pulang Pisau, Central Kalimantan-Indonesia

Literatur Review : Peran Anti-Hipertensi dalam Penurunan Tekanan Darah

Compensatory depression of arterial pressure and reversal of ECG abnormalities by Annona muricata and Curcuma longa in hypertensive Wistar rats

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