Melatonin protects against renal oxidative stress after obstructive jaundice in rats

Effect of beta-glucan in lung damage secondary to experimental obstructive jaundice

“…It has been indicated in several literature reports that GSH levels are reduced in cases of OJ (6,(24)(25)(26)(27). In an experimental study, fiener et al (28) detected that beta-glucan treatment reduced the damage caused by nicotine to the kidneys and urinary bladder, and significantly increased tissue GSH levels.…”

Protective effect of low dose of melatonin against cholestatic oxidative stress after common bile duct ligation in rats

“…It has been well established that deleterious accumulation of lipid peroxides is correlated with marked impairment of soluble antioxidant defense mechanisms and cell necrosis [5,9,14,33] . Acute BDL is associated with an increase in MDA levels and a decrease in GSH levels both in plasma and in tissue [9,10,17,[34][35][36][37] . Cruz et al [37] , have reported an increase in MDA and a decrease in GSH levels in renal tissue after biliary obstruction.…”

“…Acute BDL is associated with an increase in MDA levels and a decrease in GSH levels both in plasma and in tissue [9,10,17,[34][35][36][37] . Cruz et al [37] , have reported an increase in MDA and a decrease in GSH levels in renal tissue after biliary obstruction. As observed in previous studies, biliary tract obstruction was accompanied by increased levels of lipid peroxidation and by the depletion of GSH, a ubiquitous antioxidant, in hepatic tissue in our study.…”

“…It is shown that melatonin administration reduces histopathological signs of liver injury such as focal necrosis and apoptosis [17,27] . There are a few studies about the protective effect of low dose of melatonin against oxidative stress [27,37] . In the present study, histopathological evidence of parenchymatous injury was significantly reduced in the BDL+melatonin group (P<0.05).…”

A role of melatonin for occurrence of chronic obstructive pulmonary disease

“…- [5,[24][25][26], а также ингибировать фермент NO синта зу [11]. Показано [27][28] При воздействии мелатонина снижается уровень продуктов пероксидного окисления липидов: диено вых конъюгатов, триеновых конъюгатов, малоново го диальдегида, восстанавливается концентрация антиоксиданта глутатиона при развитии экспери ментального холестаза [29] и почечной недостаточ ности [30][31]. Повышенное содержание продуктов пероксидного окисления липидов в сыворотке кро ви свидетельствует о том, что развитие и прогресси рование этого заболевания сопровождается оксида тивным стрессом и накоплением в организме продуктов свободнорадикального окисления биомо лекул.…”