Meloxicam Self-Nanoemulsifying Drug Delivery System: Formulation and Release Kinetics Analysis

Aulia, S. D.; Winarti, Lina; Wicaksono, Yudi

doi:10.22159/ijap.2021.v13s4.43856

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…Pengujian dilakukan pada formula SNEDDS sebanyak 3 siklus pada suhu yang berbeda, yaitu 4°C (Refrigerator, Toshiba-Japan) dan 45°C (Oven, Memmert-Germany) dengan waktu penyimpanan pada setiap suhu tidak kurang dari 24 jam. Formula dikatakan stabil jika tidak terjadi pemisahan fase yang dilanjutkan dengan uji sentrifugasi [26].…”

Section: Pengujian Stabilitas Termodinamika Heating-cooling Cycleunclassified

“…Pengujian dilakukan pada formula SNEDDS sebanyak 3 siklus pada suhu beku yaitu -21˚C dan suhu kamar yaitu 28 ± 3˚C dengan waktu penyimpanan pada setiap suhu tidak kurang dari 24 jam. Formula dikatakan stabil jika tidak terjadi pemisahan fase [19,26,27]…”

Section: Freeze-thaw Cycleunclassified

“…Pada Tabel 2 menunjukkan bahwa dari 18 formula basis SNEDSS, formula F1, F2, F3, F4, F5, F6, F7, F8, F9, F10, F11 dan F12 yang terdispersi dengan cepat dan sempurna kurang dari 1 menit. Hal ini dapat disebabkan oleh adanya komponen surfaktan dan kosurfaktan yang dapat menurunkan tegangan permukaan antara fase air dan fase minyak sekaligus memodulasi waktu emulsifikasi sehingga mudah terdispersi dengan membentuk tipe emulsi minyak dalam air (M/A) [26,44].…”

Section: Optimasi Formula Basis Sneddsunclassified

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Formulasi dan Karakterisasi Self-Nanoemulsifying Drug Delivery System (SNEDDS) Esomeprazol Magnesium Trihidrat

2023

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Esomeprazol magnesium trihidrat merupakan obat golongan proton pump inhibitor (PPI) yang dapat digunakan dalam pengobatan tukak lambung dengan menghambat sekresi asam lambung. Namun esomeprazol dikategorikan ke dalam BCS kelas 2 dengan kelarutan yang buruk dalam air sehingga dapat berdampak pada kemampuan disolusi dan bioavailabilitasnya. SNEDDS umum digunakan untuk meningkatkan kelarutan obat lipoflilik dimana SNEDDS merupakan campuran zat aktif, minyak, surfaktan, dan ko-surfaktan yang akan membentuk nanoemulsi minyak dalam air secara spontan ketika kontak dengan fase cair dengan agitasi yang ringan. Tujuan dari penelitian ini yaitu untuk mengetahui formula SNEDDS esomeprazol magnesium trihidrat yang paling baik serta mengetahui karakteristiknya. SNEDDS diformulasikan menggunakan fase minyak berupa VCO, surfaktan berupa tween 80, dan ko-surfaktan berupa PEG 400. Sediaan SNEDDS dilakukan evaluasi berupa persen transmitan, dispersibilitas, robustness, stabilitas termodinamika, indeks bias, ukuran globul, PDI, zeta potensial, dan uji disolusi. Hasil menunjukkan bahwa SNEDDS esomeprazol magnesium trihidrat dengan rasio minyak:Smix 1:6 dan perbandingan Smix 2:1 mampu membentuk nanoemulsi secara spontan dan stabil berdasarkan uji stabilitas termodinamika, dihasilkan rata-rata ukuran globul 78,03 nm, nilai PDI 0,667, nilai zeta potensial -14,57 mV, dan dapat meningkatkan kecepatan disolusi yang lebih baik dibandingkan bentuk murninya.

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Section: Pengujian Stabilitas Termodinamika Heating-cooling Cycleunclassified

Section: Freeze-thaw Cycleunclassified

Section: Optimasi Formula Basis Sneddsunclassified

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Formulasi dan Karakterisasi Self-Nanoemulsifying Drug Delivery System (SNEDDS) Esomeprazol Magnesium Trihidrat

2023

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Screening of Piroxicam Self-Nanoemulsifying Drug Delivery System (Snedds) Using Fractional Factorial Design

Nugroho

Kuncahyo

Marlina

2023

JKR

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Piroxicam belongs to BCS class II and has low solubility. Self-nanoemulsifying drug delivery systems (SNEDDS) are considered a potential approach for increasing the solubility and release of piroxicam. This study aimed to select the components and component ratios of piroxicam SNEDDS using fractional factorial design 26-2 (FFD). The variables used in the DFT development of piroxicam SNEDDS are the type and concentration of oil (triacetin and oleic acid), surfactant (kolliphor EL and Tween 60), and co-surfactants (Transcutol and PEG 400). The FFD results showed 16 runs with different proportions of the piroxicam SNEDDS components, which were then characterized by critical parameters including emulsification time, %transmittance, droplet size, and drug loading. The components and component ratios of the PKM SNEDDS were determined using single-factor plot analysis. The results showed that triacetin (oil), kolliphor EL (surfactant), Transcutol (co-surfactant) had the greatest contribution to the formation of piroxicam SNEDDS with an oil ratio range of 11.11–28.57%, surfactant 44.44–77.78%, co-surfactant 11.11–44.44 %.

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Response Surface Methodology-Aided Development of Pirfenidone-Loaded Solid Lipid Nanoparticles for Intrapulmonary Drug Delivery System

KWOK,

SUHARIYONO,

SURINI

2024

Int J App Pharm

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Objective: This study aims to determine the optimized Pirfenidone-loaded Solid Lipid Nanoparticles (P-SLN) formula for Intrapulmonary Drug Delivery System (IPDDS) using Response Surface Methodology (RSM). Methods: Box-Behnken design was applied to create fifteen P-SLN formulas comprising three independent variables, namely lipid-to-drug ratio, polymer type, and polymer concentration, and three dependent variables, including particle size, Polydispersity Index (PDI), and entrapment efficiency. The P-SLNs were prepared by solvent injection followed by the ultrasonication method. Those formulas were optimized with the RSM approach using the Design Expert®. Then, the optimized P-SLN was further characterized for morphology, moisture content, aerodynamic performance, and dissolution profile. Results: The optimization process, assisted by RSM, determined that the optimized P-SLN had a lipid-to-drug ratio of 6:1 and contained 0.5% Plasdone K-29/32. The resulting P-SLN had a spherical shape with a particle size of 212.7 nm, a PDI of 0.39, an entrapment efficiency of 95.02%, and a low moisture content of 1.59%. The optimized P-SLN also exhibited appropriate IPDDS required characteristics, including a Mass Median Aerodynamic Diameter (MMAD) ranging from 0.540–12.122 μm and a Respirable Fraction (RF) of 12.4%. Moreover, the release of pirfenidone from this optimized formula was 89.61% and 69.28% in pH 4.5 and 7.4 buffer media, respectively, in 45 min through a combination of diffusion and polymer swelling mechanisms. Conclusion: The optimized P-SLN showed promising potential as an IPDDS for pirfenidone.

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Meloxicam Self-Nanoemulsifying Drug Delivery System: Formulation and Release Kinetics Analysis

Cited by 3 publications

References 21 publications

Formulasi dan Karakterisasi Self-Nanoemulsifying Drug Delivery System (SNEDDS) Esomeprazol Magnesium Trihidrat

Formulasi dan Karakterisasi Self-Nanoemulsifying Drug Delivery System (SNEDDS) Esomeprazol Magnesium Trihidrat

Screening of Piroxicam Self-Nanoemulsifying Drug Delivery System (Snedds) Using Fractional Factorial Design

Response Surface Methodology-Aided Development of Pirfenidone-Loaded Solid Lipid Nanoparticles for Intrapulmonary Drug Delivery System

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