Metal–Organic-Framework-Derived 2D Carbon Nanosheets for Localized Multiple Bacterial Eradication and Augmented Anti-infective Therapy

Abstract

Recently emerging graphene-based 2D nanoplatforms with multiple therapeutic modalities provide enormous opportunities to combat pathogenic bacterial infections. However, because these materials suffer from complicated synthesis, massive dosage requirements, and abundant nonlocalized heat, much more simplified, tunable, and localized eradication approaches are urgently required. Herein, we report on the fabrication of the metal−organic-framework (MOF)-derived 2D carbon nanosheets (2D-CNs) with phase-to-size transformation and localized bacterial eradication capabilities for augmented anti-infective therapy. The MOFderived, ZnO-doped carbon on graphene (ZnO@G) is first synthesized and then anchored with phase transformable thermally responsive brushes

ZnO/Nanocarbons‐Modified Fibrous Scaffolds for Stem Cell‐Based Osteogenic Differentiation

“…As with previous report, Figure 1k shows two characteristic peaks at 1044.7 and 1021.7 eV in the Zn 2p spectra. [ 54 ] Figure 1l suggests the measured atom ratio of C, N, O, and Zn are 62.04, 18.35, 12.55, and 7.04 at%, respectively. According to the data above, it is believed that C‐ZnO nanocarbons were successfully synthesized.…”

“…In this work, motivated by their advantages of Zn‐based MOF‐derived nanocarbons, [ 47,52,54,55 ] we have constructed C‐ZnO nanocarbons‐modified fibrous scaffolds for stem cell‐based osteogenic differentiation. Although ZIF‐8 is size‐morphology tunable and could contain multiple metal ions, they are not quite stable, especially in the acidic environment.…”

Leveraging metal oxide nanoparticles for bacteria tracing and eradicating

“…For example, ZnO-doped carbon on graphene (TRB-ZnO@G) nanosheets with phase transformable thermal-responsive brushes (TRB) polymer layers was developed recently ( Figure 4A). 97 With the aid of multiple function materials, such hybrid provided many unique characteristics such as the localized massive Zn 2+ ions penetration for bacterial damage, physical cutting, and NIR-triggered photothermal effect ( Figure 4B), which result in synergistically enhanced disruption of bacterial membranes and intracellular substances, thus achieving broad-spectrum and robust antibacterial activities.…”

Augmenting Intrinsic Fenton-Like Activities of MOF-Derived Catalysts via N-Molecule-Assisted Self-catalyzed Carbonization

“…Owing to their varied structural features, such as high surface area, tunable metal ions/organic linkers, and facile structural controllability, MOFs have been used as suitable starting materials for fabricating heteroatoms or metal particle-doped carbon hybrids, which have been applied in the fields of electro/ photocatalysis, batteries, nanomedicines, etc. [22][23][24][25]. For instance, we have reported using MOF coating to achieve highly active atomic Fe-N x catalytic centers on mesoporous carbon nanofibers for advanced oxygen electrode in metal-air batteries [26].…”