Monolayer Detection of Biochemical Agents Using Etched-Core Fiber Bragg Grating Sensors

Saini, Simarjeet S.; Stanford, C.; Lee, S.M.; Park, J.; DeShong, Philip; Bentley, William E.; Dagenais, M.

doi:10.1109/lpt.2007.902345

Cited by 39 publications

(22 citation statements)

References 6 publications

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“…For example, some special fiber sensor designs, such as the exposed-core technique now being used in etched-core FBG sensors, were first realized by using polymer optical fibers. [62][63][64] Although most POFs have a higher refractive index than silica, a single-mode perfluorinated POF with a refractive index of 1.34 has been fabricated. 60 This low-index fiber has the potential for improvement in the performance of biosensors, because it results in a stronger optical coupling between a light signal and the surrounding biosensor analyte.…”

Section: Plastic Optical Fibersmentioning

confidence: 99%

Review of diverse optical fibers used in biomedical research and clinical practice

et al. 2014

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Abstract. Optical fiber technology has significantly bolstered the growth of photonics applications in basic life sciences research and in biomedical diagnosis, therapy, monitoring, and surgery. The unique operational characteristics of diverse fibers have been exploited to realize advanced biomedical functions in areas such as illumination, imaging, minimally invasive surgery, tissue ablation, biological sensing, and tissue diagnosis. This review paper provides the necessary background to understand how optical fibers function, to describe the various categories of available fibers, and to illustrate how specific fibers are used for selected biomedical photonics applications. Research articles and vendor data sheets were consulted to describe the operational characteristics of conventional and specialty multimode and single-mode solid-core fibers, double-clad fibers, hard-clad silica fibers, conventional hollow-core fibers, photonic crystal fibers, polymer optical fibers, side-emitting and side-firing fibers, middle-infrared fibers, and optical fiber bundles. Representative applications from the recent literature illustrate how various fibers can be utilized in a wide range of biomedical disciplines. In addition to helping researchers refine current experimental setups, the material in this review paper will help conceptualize and develop emerging optical fiber-based diagnostic and analysis tools.

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Section: Plastic Optical Fibersmentioning

confidence: 99%

Review of diverse optical fibers used in biomedical research and clinical practice

et al. 2014

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“…EFBGs have also been used for measuring molecular surface adsorption, though less widely, compared to their use for bulk refractometry [21], [22]. For example, Saini et al has demonstrated the detection of a monolayer of 3-aminopropyl-monoethoxydimethyl-silane and polymers of 3-aminopropyl-triethoxysilane on the surface of an EFBG [23]. For bulk index sensing, refractive index resolution of has been reported by Ladicicco et al [24] and a higher sensitivity sensor with an index resolution of has been reported by Athanasios et al [25], in which the fiber was etched down to 3.4 exposing the core to the surrounding medium.…”

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confidence: 99%

Calibration of Etched Fiber Bragg Grating Sensor Arrays for Measurement of Molecular Surface Adsorption

Mudachathi

Shivananju

Prashanth

et al. 2013

J. Lightwave Technol.

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Etched Fiber Bragg Grating (EFBG) sensors are attractive from the point of the inherently high multiplexing ability of fiber based sensors. However, the strong dependence of the sensitivity of EFBG sensors on the fiber diameter requires robust methods for calibration when used for distributed sensing in a large array format. Using experimental data and numerical modelling, we show that knowledge of the wavelength shift during the etch process is necessary for high-fidelity calibration of EFBG arrays. However as this approach requires the monitoring of every element of the sensor array during etching, we also proposed and demonstrated a calibration scheme using data from bulk refractometry measurements conducted post-fabrication without needing any information about the etching process. Although this approach is not as precise as the first one, it may be more practical as there is no requirement to monitor each element of the sensor array. We were able to calibrate the response of the sensors to within 3% with the approach using information acquired during etching and to within 5% using the post-fabrication bulk refractometry approach in spite of the sensitivities of the array element differing by more than a factor of 4. These two approaches present a tradeoff between accuracy and practicality.Index Terms-Etched fiber Bragg grating, FBG sensor arrays, fiber array based biosensing.

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“…[3][4][5][6][7][8] For these sensors, we completely removed the cladding and even part of the core of the fiber. We have demonstrated sensors with sensitivity to changes of the index of refraction of order 7 × 10 −7 .…”

Section: Introductionmentioning

confidence: 99%

Optical characterization of refractive index sensors based on planar waveguide Fabry–Pérot Bragg grating cavity

et al. 2013

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Abstract. The evanescent field-based polymeric planar waveguide refractive index sensors having a high Q Fabry-Pérot (FP) cavity between identical dual Bragg gratings corrugated on the surface of the planar waveguide were developed. The FP Bragg gratings cavity was fabricated with a cavity size of 5 and 7 mm, respectively. The spectra of light reflected from fabricated Bragg gratings, which were butt joined, were measured and compared with different indices of surrounding media. It was obtained that the FP Bragg gratings cavity is more sensitive than the single Bragg grating. The sensor developed shows much promise in the application of biomedical diagnostics such as a biosensor and/or environmental monitoring systems. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Monolayer Detection of Biochemical Agents Using Etched-Core Fiber Bragg Grating Sensors

Cited by 39 publications

References 6 publications

Review of diverse optical fibers used in biomedical research and clinical practice

Review of diverse optical fibers used in biomedical research and clinical practice

Calibration of Etched Fiber Bragg Grating Sensor Arrays for Measurement of Molecular Surface Adsorption

Optical characterization of refractive index sensors based on planar waveguide Fabry–Pérot Bragg grating cavity

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