Mosquito larvicidal limonoids from the fruits of Chisocheton erythrocarpus Hiern

Chong, Soon-Lim; Hematpoor, Arshia; Hazni, Hazrina; Sofian‐Azirun, Mohd; Litaudon, Marc; Supratman, Unang; Murata, Michio; Awang, Khalijah

doi:10.1016/j.phytol.2018.12.013

Cited by 22 publications

(18 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Limonoid merupakan senyawa turunan triterpenoid yang teroksigenasi (Zhang and Xu, 2017) dan kehilangan empat atom karbon terminal pada rantai samping sehingga terbentuk cincin furan (Chen et al, 2018). Senyawa ini banyak ditemukan pada genus Chisocheton dengan aktivitas biologis, seperti antikanker (Nurlelasari et al, 2017), antimalaria (Nurlelasari et al, 2016), anti-inflamasi (Hoai et al, 2018), anti-obesitas (Wong et al, 2014), insektisida (Chong et al, 2019), antijamur (Bordoloi et al, 1993), dan anti-plasmodial (Mohamad et al, 2009).…”

Section: Pendahuluanunclassified

“…Saat ini genus Chisocheton menjadi fokus para ilmuwan bahan alam dalam melakukan screening bioaktivitas dan studi fitokimia untuk mendapatkan senyawa baru yang memiliki aktivitas biologis (Shilpi et al, 2016). Senyawasenyawa yang berhasil diisolasi dari genus Chisocheton memiliki aktivitas biologis, seperti antikanker (disobinol, disobinin, nimonol, dan 7α-hidroksineotrisilenon) (Nurlelasari et al, 2017), antimalaria (disobinin) (Nurlelasari et al, 2016), anti-inflamasi (Hoai et al, 2018), anti-obesitas (ceramicin B) (Wong et al, 2014), insektisida (14deoxy-∆1415-xyloccensin K dan 14-deoxyxyloccensin K) (Chong et al, 2019), antijamur (1,2-dihidro-6αasetoksiazadiron) (Bordoloi et al, 1993), dan anti-plasmodial (ceramicin B-D) (Mohamad et al, 2009). Sekitar 130 senyawa dari 11 spesies telah terisolasi, yaitu dari spesies C. ceramicus, C. paniculatus, C. erythrocarpus, C. polyandrus, C. cumingianus, C. tomentosus, C. siamensis, C. penduliflorus, C. weinlandii, C. microcarpus, dan C. macrophyllus.…”

Section: Senyawa Limonoid Dari Tumbuhan Chisochetonunclassified

See 1 more Smart Citation

Senyawa Golongan Limonoid dari Tanaman Genus Chisocheton dan Aktivitas Antikankernya

2021

View full text Add to dashboard Cite

Indonesia merupakan negara yang kaya akan keanekaragaman hayati. Terdapat banyak tanaman yang mengandung senyawa metabolit sekunder yang memiliki aktivitas biologi sehingga berpotensi untuk digunakan sebagai obat, salah satunya adalah genus Chisocheton. Tanaman genus Chisocheton sudah banyak dilaporkan mengandung senyawa triterpenoid, seskuiterpenoid, limonoid, steroid, dan fenol. Limonoid merupakan turunan triterpenoid yang paling banyak ditemukan pada tanaman genus Chisocheton. Lebih dari tiga puluh senyawa golongan limonoid telah diuji aktivitas antikankernya terhadap beberapa jenis sel kanker manusia, seperti sel kanker payudara, mulut, paru-paru, leukimia, serviks, dan hati. Beberapa senyawa limonid tersebut diketahui memiliki aktivitas sitotoksik yang tinggi dengan kisaran nilai IC50 1,67 − 50,27 µg/mL. Review ini memaparkan beberapa senyawa limonoid yang diisolasi dari genus Chisocheton, aktivitas sitotoksiknya terhadap sel-sel kanker manusia, serta hubungan struktur dan aktifitas biologisnya (SAR = Structure Activity Relationship). Selain itu beberapa penelitian juga sudah melakukan penelitian lebih lanjut seperti pengujian induksi apoptosis dan penentuan tingkat ekspresi gen-gen yang berhubungan dengan apoptosis. Penelitian-penelitian yang dilakukan ini mengarah pada pencarian senyawa baru yang dapat digunakan sebagai lead compound untuk mendapatkan obat antikanker yang efektif.Limonoid Compounds from Genus Chisocheton Plant and Its Anticancer Activity. Indonesia is a country with a large biodiversity. There are many plants contain secondary metabolite compounds with biological activity, such as Chisocheton genus. The Chisocheton is reported as plant with triterpenoids, sesquiterpenoids, limonoids, steroids and phenols content. Limonoids arethe derivative of triterpenoid which mostly found in Chisocheton genus. More than thirty limonoids have been studied for their anticancer activity against several types of human cancer cells, such as breast, mouth, lung, leukemia, cervical, and liver cancer cells. Some of these limonoids are known to have high cytotoxic activity with the IC50 values of 1.67 − 50.27 µg/mL. This review discuss many kind of limonoid compounds isolated from Chisocheton, their cytotoxic activity against human cancer cells, and their structural activity relationship (SAR) study. This review also discusses some research result for further studies of Chisocheton wether in the mechanism of apoptosis induction and also the determination genes level expression or proteins associated with the apoptosis. This review reveals the important of the study to find a new compounds for an effective anticancer drug.

show abstract

Section: Pendahuluanunclassified

Section: Senyawa Limonoid Dari Tumbuhan Chisochetonunclassified

Senyawa Golongan Limonoid dari Tanaman Genus Chisocheton dan Aktivitas Antikankernya

2021

View full text Add to dashboard Cite

show abstract

“…Meliaceae is a family of timber trees that are a rich source for limonoids and are widely distributed in tropical and subtropical regions with 50 genera and more than 1400 species [3,4]. Limonoids isolated from species of the family Meliaceae have been reported to have biologically activity as antifeedant, antimicrobial, antimalarial, and cytotoxins [5][6][7][8]. Genus Chisocheton is the second largest in the family Meliaceae, consisting of more than 50 species distributed across Nepal, India, Bhutan, Myanmar, South China, Thailand, Indonesia, Malaysia, and Papua New Guinea [7,9].…”

Section: Introductionmentioning

confidence: 99%

A new havanensin-type limonoid from Chisocheton macrophyllus

et al. 2021

Self Cite

View full text Add to dashboard Cite

A new havanensin-type limonoid, 16β-hydroxydysobinin (1), along with four known limonoids (2–5), have been isolated from the seeds of Chisocheton macrophyllus. The chemical structure of the new compound was determined by referencing spectroscopic data, and by comparison to those related spectra previously reported. Each compound was evaluated for their cytotoxic effects against Michigan Cancer Foundation-7 (MCF-7) breast cancer cells and display no significant activity.

show abstract

“…Limonoids occur mainly in the plant order of Rutales and most of them are found in Meliaceae and Rutaceae families (Li, Peng, & Zheng, 2016). Limonoids isolated from species of the family of Meliaceae have been of interest due to their diverse structures and their biological activities, including antifeedant, anticancer, antimicrobial, antimalarial, and antiviral properties (Tan, & Luo, 2011;Wong et al, 2011;Gualdani, Cavalluzzi, Lentini, & Habtemariam, 2016;Shilpi et al, 2016;Chong et al, 2019;Supratman et al, 2020). Nimbolide is a major limonoid isolated from the leaves of Azadirachta indica A. Juss or known as neem tree.…”

Section: Introductionmentioning

confidence: 99%

Two Limonoids from The Seeds of Chisocheton Macrophyllus and Their Cytotoxic Activity Against Mcf-7 Breast Cancer Cells

Rahmayanti

Nurlelasari

Harneti

et al. 2021

Molekul

Self Cite

View full text Add to dashboard Cite

Limonoids (tetranortriterpenoids) are triterpenoid compounds that lose four terminals in their structural framework. These compounds have a wide variety of structures and interesting activities including anti-inflammatory, anti-cancer, anti-tumor and anti-malarial properties. The purpose of this study was to find limonoid compounds from the Indonesian Chisocheton plant, and one of which is Chisocheton macrophyllus. The dried and powdered seeds of C. macrophyllus (4.5 kg) were extracted with methanol and partitioned successively with n-hexane, ethyl acetate and n-butanol. Evaporation of each extract resulted in the crude extracts of n-hexane (346.6 g), ethyl acetate (60.8 g) and n-butanol (14.6 g). The n-hexane fraction was subjected to a silica gel vacuum-liquid chromatography (VLC) column packed with silica gel 60 using gradient of n-hexane, ethyl acetate and methanol (10% stepwise) to afford thirteen fractions (A-M). Fraction F (4.4 g) was subjected to silica gel column chromatography using gradient of n-hexane and ethyl acetate (5% stepwise). Subfraction F5 (1.2 g) was chromatographed on a column of silica gel eluted with n-hexane: CH2Cl2: EtOAc (2:7.5:0.5) to give compound 1 (19.7 mg) and fraction H (1.8 g) was subjected to silica gel column chromatography using gradient of n-hexane and ethyl acetate (5% stepwise) as eluting solvent to give 2 (12.0 mg). Chemical structures of 1 and 2 were elucidated by spectroscopic methods and determined as 6α-acetoxyepoxyazadiradione (1) and Dysobinin(2). Dysobinin (2) showed weak cytotoxic activity against MCF-7 breast cancer cells with an IC50 value of 228.15 μM

show abstract

Mosquito larvicidal limonoids from the fruits of Chisocheton erythrocarpus Hiern

Cited by 22 publications

References 14 publications

Senyawa Golongan Limonoid dari Tanaman Genus Chisocheton dan Aktivitas Antikankernya

Senyawa Golongan Limonoid dari Tanaman Genus Chisocheton dan Aktivitas Antikankernya

A new havanensin-type limonoid from Chisocheton macrophyllus

Two Limonoids from The Seeds of Chisocheton Macrophyllus and Their Cytotoxic Activity Against Mcf-7 Breast Cancer Cells

Contact Info

Product

Resources

About