Neurite outgrowth induced by spicatoside A, a steroidal saponin, via the tyrosine kinase A receptor pathway

Hur, Jinyoung; Lee, Pyeongjae; Moon, Eunjung; Kang, Insug; Kim, Sung Hoon; Oh, Myung Sook; Kim, Sun Yeou

doi:10.1016/j.ejphar.2009.08.016

Cited by 70 publications

(72 citation statements)

References 36 publications

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“…C6와 일차성상세포(primary astrocyte cells)에 맥문 동의 부탄올 추출물(butanol extract)을 처리하면, 이들 세 포로부터 신경세포의 분화와 성장에 중요한 신경성장인 자(nerve growth factor, NGF)의 분비를 촉진된다 (Hur et al, 2004). 또한, 맥문동에서 분리한 Spicatoside A를 PC12 세포에 처리하면, tyrosine kinase A receptor pathway를 통해 신경극 성장(neurite outgrowth)이 촉진된 다 (Hur et al, 2009). 더불어, 맥문동의 에탄올분획 (ethanol extract)을 14일 동안 마우스에 투여하면, 맥문동 은 마우스의 뇌에서 뇌유래 신경영양인자(Brain-derived neurotrophic factor, BDNF)나 NGF 발현증가에 의해 기억 력과 학습력 증가를 유도하였다 (Lee et al, 2005 Figure 1.…”

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The Symptoms of Atopic Dermatitis in NC/Nga Mice Were Significantly Relieved by the Water Extract ofLiriope platyphylla

et al. 2010

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Atopic dermatitis is an well-known skin disease showing inflammatory, chronically relapsing, noncontagious and pruritic symptoms. The aims of this study were to investigate the effects of Liriope platyphylla (LP) on atopic dermatitis of NC/Nga mice. To achieve this, NC/Nga mice were treated with four different conditions including vehicle, phthalic anhydride (PA), PA+5% LP and PA+10% LP, and the changes of immune-related factors were detected after 2 weeks. The pathological phenotypes of atopic dermatitis such as erythema, ear thickness, edema, scab and discharge were significantly decreased in PA+10% LP cotreated groups compare to PA treated group. Also, the weight of lymph node and thymus in immune organs were gradually decreased in LP treated groups, while the weight of spleen was slightly increased in same group. Furthermore, toluidine blue staining analysis, a method used to specifically identify the mast cell, showed that the decrease of master cell infiltration into the dermis were statistically observed in PA+5% LP and PA+10% LP5% cotreated groups. Especially, the decrease of IgE concentration was detected only PA+10% LP cotreated group, although this level was maintained in PA+5% LP cotreated group. Therefore, these results suggested that the water extracts of LP may contribute the relieve of atopic dermatitis symptoms and be considered as an excellent candidate for a atopic dermatitis-therapeutic drug.

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The Symptoms of Atopic Dermatitis in NC/Nga Mice Were Significantly Relieved by the Water Extract ofLiriope platyphylla

et al. 2010

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“…Spicatoside A from Liriope platyphylla enhances neurite outgrowth in PC12 cells and also potentiates the release of trophic factors that are beneficial in neurodegenerative diseases [36]. Neurotrophic factors were activated via PI3K-dependent pathways or other intracellular signalling pathways and promoted neuronal survival and neurite outgrowth [37,38].…”

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confidence: 99%

Gnetol, a Resveratrol Derivative Ameliorates Malathion-Induced Neurotoxicity through Modulating Lysosomal Membrane Permeabilization in N2a Cells

Venkatesan¹,

Park²,

Lee³

et al. 2017

J Alzheimers Dis Parkinsonism

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“…또한 PC-12세포를 이용하여 맥문동의 butanol 분획물이 신 경세포 성장에 기여하고 18) , 맥문동의 성분인 spicatoside A가 nerve growth factor (NGF)의 분비를 촉진한다 19) 는 맥문동물추출물 50 µg/ml주입군(LT50)에서 PC-12 cell 생존율은 101 ± 6.83%였고, 맥문동물추출물 100 µg/ml주입군(LT100)의 PC-12 cell 생존율은 105 ± 5.21%이였다. 맥문동물추출물 200 µg/ml주입군(LT200)의 PC-12 cell 생존율은 109 ± 6.35%였고, 맥문동물추출물 400 µg/ml주입군(LT400)의 PC-12 cell 생존율은 101 ± 6.87%로 실험군 모두 대조군에 비해 증가하였으나 유의성 은 없었다 (Fig 1).…”

Section: 서 론 1)2)unclassified

Effects of Liriopis Tuber on 4-HNE-induced Apoptosis in PC-12 Cells

Park¹,

Kim²

2013

The Korea Journal of Herbology

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Objects : Apoptosis leads to the death of a cell. The mitochondrial pathway of apoptosis, a process regulated by the Bcl-2 family of proteins, plays a key role in various biological processes. The tuber of Liriope platyphylla Wang et TANG (Liliaceae), also known as Liriopis tuber, is famous in Oriental medicine owing to its tonic, antitussive, expectorant and anti-asthmatic properties. The purpose of this study was to observe the effect of the Liriopis tuber on mitochondrial -mediated apoptosis in PC-12 cells. Method : A cytotoxic test on Liriopis Tuber water extract was conducted and another MTT assay was conducted to observe the cytoprotective effect against 4-HNE 25 µM that causes oxidative stress in PC-12 cells for 24 hours. In addition, in order to observe the expression of Bcl-2 and Bax protein involved with apoptosis, western blot was conducted. Results : The LT water extract had no toxicity for PC-12 cell. In the cytoprotective effect against 4-HNE, both of the group treated with 50 µg/㎖ and 100 µg/㎖ of LT water extract showed a significant increase in comparison with the control group. In Bax protein expression, all the experimental groups treated with LT water extract showed a decrease in comparison with the control group but had no significance. In Bcl-2 protein expression, all the experimental groups treated with LT water extract showed a significant increase in comparison with the control group. Conclusion : These results suggest that LT is effective in reducing apoptosis.

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Neurite outgrowth induced by spicatoside A, a steroidal saponin, via the tyrosine kinase A receptor pathway

Cited by 70 publications

References 36 publications

The Symptoms of Atopic Dermatitis in NC/Nga Mice Were Significantly Relieved by the Water Extract ofLiriope platyphylla

The Symptoms of Atopic Dermatitis in NC/Nga Mice Were Significantly Relieved by the Water Extract ofLiriope platyphylla

Gnetol, a Resveratrol Derivative Ameliorates Malathion-Induced Neurotoxicity through Modulating Lysosomal Membrane Permeabilization in N2a Cells

Effects of Liriopis Tuber on 4-HNE-induced Apoptosis in PC-12 Cells

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