New Resorcinol Derivatives from a Sponge‐Derived Fungus Hansfordia sinuosae

Abstract

Ten new resorcinol derivatives named hansfordiols A - J (1 - 10) were isolated from the fermentation broth of the sponge-derived fungus Hansfordia sinuosae. High resolution electron ionization mass spectrometry, FT-IR spectroscopy, and NMR techniques were used to elucidate the structures of these compounds, and the absolute configurations were established by the modified Mosher's method and their specific optical rotation. The structures of compounds 8 - 10 were featured with various chlorination at aromatic rings. Their antioxidant activities on ABTS, cytotoxicity on the HCT-8, Bel-7402, BGC-823, A549, and A2780 cell lines, and antibacterial activities were evaluated.

Newly discovered naturally occurring organohalogens

“…From the South China Sea, afforded the novel chlorinated resorcinol hansfordiols H -J (103 -105), in addition to seven nonchlorinated analogues. 40 Hansfordiols H and I show good antioxidant activity comparable to Trolox, but no antibacterial activity or cytotoxicity against several cell lines. The fungus Penicillium sp.…”

Chemistry, Biosynthesis, and Biological Activity of Halogenated Compounds Produced by Marine Microorganisms

“…Three new resorcinol derivatives, named hansfordiols H—J ( 145 — 147 ), were isolated from the fermentation broth of the sponge‐derived fungus Hansfordia sinuosae , which showed possessing moderate antioxidant activities. [ 84 ]

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Biological and Chemical Diversity of Marine Sponge-Derived Microorganisms over the Last Two Decades from 1998 to 2017

“…Compounds 340-345 showed weak cytotoxic activity against a panel of tumor cell lines with IC 50 values more than 10 µM and showed weak inhibitory effects against the bacterial strains with the MIC values more than 125 µM. Compounds 346-358 did not do well in their bioassays [112][113][114]. Chemical structures of molecules 317-339 isolated from the above fungus Stachybotrys chartarum.…”