Novel biodegradable electrospun nanofibrous P(DLLA-CL) balloons for the treatment of vertebral compression fractures

Sun, Gang; Wei, Daixu; Liu, Xunwei; Chen, Yuyun; Li, Min; He, Daping; Zhong, Jian

doi:10.1016/j.nano.2012.12.003

Cited by 60 publications

(53 citation statements)

References 40 publications

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“…26 In this work, the in vivo observation of ENPB-CPCs showed that the ENPBs separated CPC from the surrounding bone microenvironments in rabbit thighbones (Fig. 4) and pig vertebrae (Fig.…”

Section: In Vitro and In Vivo Separation Behavior Of Enpbsmentioning

confidence: 50%

“…26 Before moving to clinical application, the in vitro and in vivo behaviors of the ENPBs were systematically evaluated in this work. This work will also be of benefit to the development of polymer-based medical implants in the future.…”

Section: Discussionmentioning

confidence: 99%

“…1A) according to our previous work. 26 Briefly, a 10-mL glass syringe filled with P(DLLA-CL) solution was fitted with a needle and placed on a KDS-200 syringe pump (Stoelting Co., Wood Dale, IL, USA). The tip diameter of the needle was 0.9 mm.…”

Section: P(dlla-cl) Nanofibers and Enpbs Fabricationmentioning

confidence: 99%

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Electrospun Nanofibrous P(DLLA–CL) Balloons as Calcium Phosphate Cement Filled Containers for Bone Repair: in Vitro and in Vivo Studies

Liu

Wei

Zhong

et al. 2015

ACS Appl. Mater. Interfaces

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The spinal surgeon community has expressed significant interest in applying calcium phosphate cement (CPC) for the treatment of vertebral compression fractures (VCFs) and minimizing its disadvantages, such as its water-induced collapsibility and poor mechanical properties, limiting its clinical use. In this work, novel biodegradable electrospun nanofibrous poly(d,l-lactic acid-ϵ-caprolactone) balloons (ENPBs) were prepared, and the separation, pressure, degradation, and new bone formation behaviors of the ENPBs when used as CPC-filled containers in vitro and in vivo were systematically analyzed and compared. CPC could be separated from surrounding bone tissues by ENPBs in vitro and in vivo. ENPB-CPCs (ENPBs serving as CPC-filled containers) exerted pressure on the surrounding bone microenvironment, which was enough to crush trabecular bone. Compared with the CPC implantation, ENPB-CPCs delayed the degradation of CPC (i.e., its water-induced collapsilibity). Finally, possible mechanisms behind the in vivo effects caused by ENPB-CPCs implanted into rabbit thighbones and pig vertebrae were proposed. This work suggests that ENPBs can be potentially applied as CPC-filled containers in vivo and provides an experimental basis for the clinical application of ENPBs for the treatment of VCFs. In addition, this work will be of benefit to the development of polymer-based medical implants in the future.

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“…26 In this work, the in vivo observation of ENPB-CPCs showed that the ENPBs separated CPC from the surrounding bone microenvironments in rabbit thighbones (Fig. 4) and pig vertebrae (Fig.…”

Section: In Vitro and In Vivo Separation Behavior Of Enpbsmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 99%

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Electrospun Nanofibrous P(DLLA–CL) Balloons as Calcium Phosphate Cement Filled Containers for Bone Repair: in Vitro and in Vivo Studies

Liu

Wei

Zhong

et al. 2015

ACS Appl. Mater. Interfaces

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“…Cell culture on SF/n-HA and n-HA materials MG-63 human osteosarcoma cells (purchased from Cell Bank of Chinese Academy of Sciences, Shanghai, China) were cultured in DMEM medium (Gibco, USA) with 10% fetal bovine serum (FBS, Gibco, USA) in an incubator supplied with 5% CO 2 at 37 C (27). The Ti alloy substrates with SF/n-HA and n-HA materials were placed into 24-well tissue culture plates (TCPs).…”

Section: Characterization Of Sf/n-ha Composites and Ha Nanocrystalsmentioning

confidence: 99%

Quantitative analyses of the effect of silk fibroin/nano-hydroxyapatite composites on osteogenic differentiation of MG-63 human osteosarcoma cells

Lin

Hao

Xiong³

et al. 2015

Journal of Bioscience and Bioengineering

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“…Recently, degradable nanofibrous poly(d,l-lactideco-ε-caprolactone) balloons (ENPBs) were prepared by electrospinning ( Figure 5). 91 Preliminary studies showed that these nanotechnology-enhanced balloon catheters could separate the cement from the surrounding environment, indicating an ability to eliminate cement leakage and prevent the water-induced collapse of cement often seen with CPC. ENPBs filled with CPC also showed enough strength to restore the height of a fractured vertebral body.…”

Section: Nanotechnology-enhanced Instruments For Treatment Of Ovf Balmentioning

confidence: 99%

Nanotechnology for treating osteoporotic vertebral fractures

Gao¹,

Wei²,

Yang³

et al. 2015

IJN

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Osteoporosis is a serious public health problem affecting hundreds of millions of aged people worldwide, with severe consequences including vertebral fractures that are associated with significant morbidity and mortality. To augment or treat osteoporotic vertebral fractures, a number of surgical approaches including minimally invasive vertebroplasty and kyphoplasty have been developed. However, these approaches face problems and difficulties with efficacy and long-term stability. Recent advances and progress in nanotechnology are opening up new opportunities to improve the surgical procedures for treating osteoporotic vertebral fractures. This article reviews the improvements enabled by new nanomaterials and focuses on new injectable biomaterials like bone cements and surgical instruments for treating vertebral fractures. This article also provides an introduction to osteoporotic vertebral fractures and current clinical treatments, along with the rationale and efficacy of utilizing nanomaterials to modify and improve biomaterials or instruments. In addition, perspectives on future trends with injectable bone cements and surgical instruments enhanced by nanotechnology are provided.

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Novel biodegradable electrospun nanofibrous P(DLLA-CL) balloons for the treatment of vertebral compression fractures

Cited by 60 publications

References 40 publications

Electrospun Nanofibrous P(DLLA–CL) Balloons as Calcium Phosphate Cement Filled Containers for Bone Repair: in Vitro and in Vivo Studies

Electrospun Nanofibrous P(DLLA–CL) Balloons as Calcium Phosphate Cement Filled Containers for Bone Repair: in Vitro and in Vivo Studies

Quantitative analyses of the effect of silk fibroin/nano-hydroxyapatite composites on osteogenic differentiation of MG-63 human osteosarcoma cells

Nanotechnology for treating osteoporotic vertebral fractures

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