Omega 3‐rich Camelina sativa oil in the context of a weight loss program improves glucose homeostasis, inflammation and oxidative stress in patients with NAFLD: A randomised placebo‐controlled clinical trial

Abstract

Background Over the past few years, the benefits of omega‐3 fatty acids have been reported in the management of non‐alcoholic fatty liver disease (NAFLD) complications.This study evaluated the effects of Camelina sativa oil (CSO) supplementation as one of the richest dietary sources of omega‐3 fatty acids on glucose homeostasis,inflammation, metabolic endotoxemia, and oxidative stress in NAFLD patients. Methods A total of 46 patients with NAFLD were allocated to either an intervention (20 g/d CSO) or placebo (20 g/d sunflower oil) group receiving a calorie‐restricted diet for 12 weeks. Fasting plasma levels of glycemic indices, hs‐CRP, lipopolysaccharide (LPS), antioxidant enzymes activity, total antioxidant capacity (TAC), malondialdehyde (MDA), 8‐iso‐prostaglandin F2α (8‐iso‐PGF2α), and uric acid were measured at baseline and post‐intervention. Results The CSO supplementation led to significant differences in insulin concentration, homeostasis model assessment of insulin resistance (HOMA‐IR), hs‐CRP, LPS, TAC, superoxide dismutase (SOD) activity, MDA and 8‐iso‐PGF2α between the two groups at end of the study (ANCOVA, P < .05). Hs‐CRP decreased significantly in both groups (pair‐t‐test, P < .05). Insulin concentration, quantitative insulin sensitivity check index, LPS, TAC, SOD, glutathione peroxidase activity, MDA and 8‐iso‐PGF2α changed significantly only in CSO group (P < .05). Conclusion These findings indicate that CSO may improve glycemia, inflammation, metabolic endotoxemia, and oxidative stress status in patients with NAFLD.

Efficacy of omega-3-rich Camelina sativa on the metabolic and clinical markers in nonalcoholic fatty liver disease: a randomized, controlled trial

“…The percent difference between the fatty acid composition of CSO and SFO has been shown in Table 1. CSO has been known as generally recognized as safe based on the provided evidence by FDA and is registered as food oil in many European countries [17].…”

The Efficacy of Camelina sativa Defatted Seed Meal against Colitis-Induced Persistent Visceral Hypersensitivity: The Relevance of PPAR α Receptor Activation in Pain Relief

“…Gut inflammation represents a major risk factor for developing visceral hypersensitivity, which characteristically persists even after the resolution of intestinal damage [ 1 , 12 , 55 ]. To date, many plant-derived products have been studied with the aim of combining different mechanisms of action to improve the therapy for post-inflammatory intestinal hyperalgesia, which is supported by inflammatory, neuropathic, and immune mechanisms [ 1 , 8 ].…”

“…Additionally, the defatted seeds of camelina are rich in GSLs like glucoarabin and glucocamelinin [ 29 , 30 , 31 ], although the biological effects of these phytochemicals are still largely unknown. There are several studies in the literature reporting the therapeutic potential of Camelina sativa oil in metabolic disorders [ 55 , 63 ], whereas there is little evidence about other effects, such as the regulation of the immune response and the inflammatory processes [ 29 , 55 , 57 , 64 ].…”

Antioxidant and Anti-Inflammatory Properties of Rubber Seed Oil in Lipopolysaccharide-Induced RAW 267.4 Macrophages

“…Dietary PUFA interferes with a variety of physiological and pathophysiological processes, thereby affecting health as well as disease processes [ 11 , 12 ]. It is well known that PUFA is beneficial against cardiovascular disease, cancer, oxidative stress, and inflammation [ 13 , 14 ].…”

“…A growing body of reports supports the therapeutic potential of PUFA on diseases based on its antioxidant and anti-inflammatory properties [ 13 , 15 ]. Both n-3 and n-6 PUFAs play important roles in antioxidation and anti-inflammation.…”