Orally Disintegrating Tablets: A Review

Hirani, Jaysukh J; Rathod, Dhaval A; Vadalia, K. R.

doi:10.4314/tjpr.v8i2.44525

Cited by 176 publications

(142 citation statements)

References 22 publications

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“…Immediate release from nonwoven system of electrospun nanofibers (called mat or web generally) has been published only in some cases [22][23][24][25]. Consequently the reviews dealing with fast dissolving oral dosage forms such as OTFs, and ODTs missed to mention this technology [3,5,[26][27][28]. Formation of non-woven tissues of the nanofibers, owing to their huge surface area, is a promising way to develop oral fast-dissolving dosage forms and the electrostatic spinning can be a capable technology for manufacturing such formulations.…”

Section: Introductionmentioning

confidence: 99%

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Electrospun water soluble polymer mat for ultrafast release of Donepezil HCl

Nagy¹,

Nyúl²,

Wagner³

et al. 2010

Express Polym. Lett.

121

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Abstract. Electrostatic spinning (Electrospinning, ES) was applied to prepare Donepezil HCl loaded nanofibers as a potential orally dissolving dosage form. Electrospinning of water solutions of different polymers were performed in order to fabricate a consistent and removable web on the collector with ultra-fast dissolution in water based media. Poly(vinyl-alcohol) of low molecular weight was found to be the most appropriate for this purpose. Morphology of the prepared nanofibers was characterized by scanning electron microscope as a function of viscosity and drug content. Diameters of the fibers were between 100 and 300 nm with narrow distribution. In vitro drug release of the webs was immediate (less than 30 s) after immersion independently of their drug content owing to the formed huge surface area, while cast films with the same compositions and commercial tablets needed 30 min or more for complete dissolution. The developed technology for the preparation of orally dissolving web (ODW) formulations is a promising way for producing effective and acceptable dosage forms for children, older people and patients with dysphagia.

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Section: Introductionmentioning

confidence: 99%

“…These disadvantages led the European Medicines Agency (EMEA) to recommend the development of solid dosage forms instead of oral liquid dosage forms [2]. The orally disintegrating tablet formulation (ODT) [3] meets the EMEA recommendation. Administration of ODTs is easy and there is no need to swal-low large particles or water.…”

Section: Introductionmentioning

confidence: 99%

Electrospun water soluble polymer mat for ultrafast release of Donepezil HCl

Nagy¹,

Nyúl²,

Wagner³

et al. 2010

Express Polym. Lett.

121

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“…FDTs disperse or dissolve in the saliva, this leads to pre-gastric drug absorption of the tablets. As a result, FDTs have greater bioavailability than that observed from conventional tablet or capsule dosage forms and avoid first metabolism which can be advantageous (Jeong et al, 2008;Hirani et al, 2009;Nagar et al, 2011;Sharma et al, 2012). For these reasons, over the past three decades FDTs have gained considerable attention (Abay and Ugurlu, 2015) and have been the favourite development of product development scientists for facilitating ease of medication (Nagar et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Application of general multilevel factorial design with formulation of fast disintegrating tablets containing croscaremellose sodium and Disintequick MCC-25

Solaiman

Suliman

Shinde

et al. 2016

International Journal of Pharmaceutics

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A B S T R A C TDespite the popularity of orally fast disintegrating tablets (FDTs), their formulation can sometimes be challenging, producing tablets with either poor mechanical properties or high disintegration times. The aim of this research was to enhance the properties of FDTs produced by direct compression to have both sufficient hardness to withstand manual handling, and rapid disintegration time. General multilevel factorial design was applied to optimise and evaluate main and interaction effects of independent variables (i) disintegrant concentration, (ii) % filler (Disintequick MCC-25) to mannitol on the responses hardness, tensile strength and disintegration time. In this experiment mannitol was used as a diluent, Disintequick MCC-25 (to best of our knowledge there is no publication available yet for its use with FDTs) was termed in this study as a filler and croscaremellose sodium was used as the superdisintegrant. ) and friability of 2.2%; (ii) 7% or 10% w/w disintegrant with 33.33% w/w filler to mannitol, showing disintegration time of 84 s (for 7% disintegrant) and 107 s (for 10% disintegrant), hardness of 73.86 N (for 7% disintegrant) and 72.68 N (for 10% disintegrant) and friability of 1.44 (for 7% disintegrant) and 1.15% (for 10% disintegrant).

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“…The benefits of MDTs is to improve patients compliance, popular as a dosage form of choice in the current market. [1,2,3] MDTs are distinguished from conventional, sublingual tablets, buccal tablets and lozenges, which require more than a minute to dissolve in oral cavity. In the literature, MDTs also are called oral disperse, mouthdissolving, quick-dissolve, fast-melt and freeze-dried wafers.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Mouth Dissolving Tablets of Oxcarbazepine

Aglawe¹

2017

WJPR

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The concept of Mouth Dissolving Drug Delivery System emerged from the desire to provide patient with conventional mean of taking their medication. Oxcarbazepine is an anticonvulsant drug, mainly used as an add-on or first line treatment in adults and children. Due to sudden onset of attack, it is necessary to formulate antiepileptics into such a delivery system, which provide immediate relief. Hence, the present investigation was undertaken with a view to develop mouthdissolving tablets of oxcarbazepine, which offers a new range of product having desired characteristics and intended benefits. In this study, the mouth dissolving tablets were prepared. A mouth dissolving tablet was prepared by using superdisintegrants viz; crospovidone, croscarmellose sodium and sodium starch glycolate All the batches are prepared by direct compression method. Effect of disintegrants concentration on the disintegration behavior was evaluated, and all the tablets were evaluated for hardness, friability, weight variation, water absorption ratio, dissolution, and assay. Among the all preparations F8 emerged as the best formulation and showed maximum dissolution rate.

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Orally Disintegrating Tablets: A Review

Cited by 176 publications

References 22 publications

Electrospun water soluble polymer mat for ultrafast release of Donepezil HCl

Electrospun water soluble polymer mat for ultrafast release of Donepezil HCl

Application of general multilevel factorial design with formulation of fast disintegrating tablets containing croscaremellose sodium and Disintequick MCC-25

Formulation and Evaluation of Mouth Dissolving Tablets of Oxcarbazepine

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