Paternal Alcohol Exposure Affects Sperm Cytosine Methyltransferase Messenger RNA Levels

Bielawski, Dawn M.; Zaher, Fadi M.; Svinarich, David M.; Abel, Ernest L.

doi:10.1097/00000374-200203000-00007

Cited by 42 publications

(57 citation statements)

References 19 publications

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“…It is reported that 75% of children with fetal alcohol syndrome have fathers who were alcoholics [120]. Alcohol consumption is associated with a deterioration of sperm parameters which may be partially reversible upon alcohol consumption discontinuation [121].…”

Section: Consumption Of Alcoholmentioning

confidence: 99%

“…Testicular deficiency may have different aetiologies and present clinically as severe oligoasthenozoospermic (OAT) or non-obstructive azoospermia (NOA) [120]. In men with testicular deficiency, hypergonadotrophic hypogonadism is usually present, with high levels of follicle-stimulating hormone (FSH) and luteinising hormone (LH), and sometimes low levels of testosterone.…”

Section: Diagnosis and Management For Infertilitymentioning

confidence: 99%

See 1 more Smart Citation

Male Infertility; Evidences, Risk Factors, Causes, Diagnosis and Management in Human

Sharma¹

2017

Ann Clin Lab Res

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Infertility has become ominous problem. On an average, about 10% of all couples face difficulty in starting a family and this creates a feeling of great personal failure, particularly in India where religious and socio-economic traditions have made it almost imperative for everyone to have children. A significant association had been found between impaired semen quality including sperm count, motility and morphology. In this review, the various contributory etiological factors i.e., exposure to heavy metals, pesticides, industrial chemicals, endocrine factors, genetics causes and modern life style had been discussed which have a serious impact on male infertility. In this article we analyzed data from different sources and present evidences of the possible etiology and risk factors for male infertility. There is a need to emerge at the indiscriminate use and disposal of environmental chemicals. Especially pesticides and industrial chemicals as the chemicals enter the food chain, surface and ground water which had potential for exposure during the critical period of development further avoiding tobacco smoking, excessive alcoholism, excessive heat exposure to the testes can help in improving the semen quality.

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Section: Consumption Of Alcoholmentioning

confidence: 99%

Section: Diagnosis and Management For Infertilitymentioning

confidence: 99%

Male Infertility; Evidences, Risk Factors, Causes, Diagnosis and Management in Human

Sharma¹

2017

Ann Clin Lab Res

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“…Mechanisms postulated for adverse testicular effects are lipid peroxidation (Rosenblum et al, 1985), changes in secretory function of Sertoli cells (Zhu et al, 1997), changes in hormone levels (Woolveridge et al, 1999), and induction of apoptosis (Eid et al, 2002;Hu et al, 2003). Bielawski et al (2002) suggest alcohol may produce transgenerational effects by decreasing cytosine methyltransferase mRNA levels and affecting normal imprinting. Kagan-Krieger et al (2002) suggest paternal alcohol consumption may affect offspring through genetic changes in sperm DNA, decreasing numbers of sperm produced resulting in a less healthy subpopulation available for fertilization, and/or altering the chemical composition of seminal fluid giving less protection for the ejaculated sperm cells.…”

Section: Sperm-fish Studies Of Alcoholmentioning

confidence: 99%

Effect of lifestyle exposures on sperm aneuploidy

Robbins¹,

Elashoff²,

Lin³

et al. 2005

Cytogenet Genome Res

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Lifestyle exposures including cigarette smoke, alcohol, and caffeine have all been studied in relationship to male reproductive health. Over the years the focus has primarily been on semen quality and/or fertility. More recently, literature evaluating direct adverse effects of lifestyle exposures on sperm chromosomes and chromatin has grown due to concern that induced damage could be transmitted to offspring causing transgenerational health effects. In this paper we present a new analysis that summarizes published studies of smoking effects on sperm chromosome number and demonstrates a statistically significant increase in sperm disomy among smokers compared to nonsmokers (P < 0.001). In addition, new data on the effect of alcohol intake on sperm chromosome number are presented showing a rate ratio of 1.38 (95% CI 1.2, 1.6) for XY frequency in sperm of alcohol drinkers compared to nondrinkers.

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“…Tanto el etanol como el acetaldehído, pueden afectar los patrones de metilación de ADN mediante la alteración de la actividad DNMTs. Así, algunas investigaciones descubrieron que el acetaldehído puede inhibir la actividad de DNMT in vitro (Garro et al, 1991) y que el alcohol reduce los niveles de mARN de DNMTs en ratas tratadas con alcohol durante 9 semanas (Bielawski et al, 2002). Del mismo modo, los estudios en humanos han encontrado que los niveles de mARN de DNMT3a y DNMT3b se redujeron significativamente en pacientes con alcoholismo crónico en comparación con los sujetos control sanos (Bönsch et al, 2006).…”

Section: Metilación Del Adnunclassified

Rol del Consumo de Alcohol y Antioxidantes sobre la Metilación Global del ADN y Cáncer

et al. 2018

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SANDOVAL, C.; VÁSQUEZ, B. SOUZA-MELLO, V.; MANDARIM-DE-LACERDA, C. A. & DEL SOL, M.Rol del consumo de alcohol y antioxidantes sobre la metilación global del ADN y cáncer. Int. J. Morphol., 36(1):367-372, 2018. RESUMEN:El alcoholismo es una enfermedad crónica recidivante asociada a disfunción psicológica, social y física. El alcohol no sólo es una droga adictiva, también produce alteraciones en las actividades y funciones de múltiples sistemas y órganos. Actualmente, diversos estudios demuestran que el ambiente puede modular la expresión génica del ADN mediante mecanismos epigenéticos, sugiriendo de esta manera, que el consumo de alcohol es un factor que puede alterar los patrones epigenéticos y, por lo tanto, los niveles de expresión génica. La metilación del ADN es un proceso epigenético que participa en la regulación de la expresión génica, impidiendo la unión de factores de transcripción y propiciando la estructura cerrada de la cromatina. En este sentido, los cambios en la metilación del ADN se reconocen como una de las formas más comunes de alteración molecular en la dependencia al alcohol y los procesos neoplásicos humanos. El alcohol puede ser un factor importante en la iniciación del cáncer, aumentando la expresión de ciertos oncogenes o reprimiendo la capacidad de las células para reparar el ADN, lo que aumenta la probabilidad de que se produzcan mutaciones oncogénicas. Sin embargo, los mecanismos exactos de la patogénesis del cáncer ligada al consumo de alcohol aún permanecen sin ser dilucidados. Por lo anterior, el objetivo de la presente revisión fue describir los mecanismos de metilación del ADN y su relación con el consumo de alcohol y cáncer.

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Paternal Alcohol Exposure Affects Sperm Cytosine Methyltransferase Messenger RNA Levels

Abstract: Alcohol-induced reductions in cytosine methyltransferase mRNA levels may reflect altered genomic imprinting caused by reduced DNA methylation, which, in turn, may lead to the expression of normally silent paternal alleles and may be a mechanism for paternal alcohol effects.

Cited by 42 publications

References 19 publications

Male Infertility; Evidences, Risk Factors, Causes, Diagnosis and Management in Human

Male Infertility; Evidences, Risk Factors, Causes, Diagnosis and Management in Human

Effect of lifestyle exposures on sperm aneuploidy

Rol del Consumo de Alcohol y Antioxidantes sobre la Metilación Global del ADN y Cáncer

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