The contribution of Local Government Owned Corporate (BUMD) to Local Own Revenue (PAD) Pati is still low (4.23 percent).Establishing a new medical waste processing company is promising as a new business unit of BUMD since the current company that manages medical waste shows low performance. This study aims to analyze the feasibility of establishing a medical waste treatment business in Pati Regency. In addition, the contribution of the new company to generate PAD also is estimated. The feasibility is assessed based on financial and non-financial aspects. The research method used is a mixed-method with dominant in a quantitative method. The result showed that the establishment of a medical waste treatment company is feasible based on non-financial and financial indicators. Non-financial aspects include market aspect, technical aspect, management and human resources aspects, social and economic aspects, and environmental aspect. Financially, the establishment of this company is feasible acoording to the following indicators: the payback period (3 years 10 months 9 days), Net Present Value (Rp5,245,526,919), and internal rate of return (28.65 percent). The establishment of this company has a good market potential since there is only one waste company as a competitor in Central Java Province. Furthermore, this company offers lower prices compared to its competitor to gain new costumers. Collecting the medical waste on time enables this company to support their customers creating better sanitation. It is estimated that this company will contribute to PAD 0.215 percent by 2023 higher than that of another unit of BUMD.