A research on drugs administration in Manado in 2014 revealed that 44.77% of the local population did not procure drugs properly, 75.9% received the wrong ones, 25.3% did not store them as suggested, and 72% did not use them appropriately. As an attempt to avoid medication management mistakes in the community, the Indonesian Pharmacist Association has introduced a program termed DAGUSIBU, an abbreviated form of 'to get, use, store, and discard'. DAGUSIBU contains information on the procedures to receive, use, store, and dispose drugs correctly; hence, immediate dissemination or education is highly suggested. High school students were involved as the main cadre in the research because adolescents are at the age of rapid physical and mental development and, thereby, the most vulnerable age group to misinformation. This study was set out to determine the effects of DAGUSIBU education on the knowledge of MA Nurul Ummah students in Yogyakarta. This experimental study involved pharmacists in providing education using the active learning method (CBIA) and focus group discussion (FGD). Student's knowledge of DAGUSIBU was assessed before and after the education using a validated questionnaire. Meanwhile, differences between the students' knowledge preand post-education were quantified using a paired sample t-test in the SPSS v.16 program. The results indicated that on the average, the students' knowledge level increased after receiving education on DAGUSIBU. Through the active learning method (CBIA), the rate of knowledge level nearly doubled from 4.2923 ± 1.54 (pre) to 7.9231± 1.04 (post) (p = 0.000), and after the FGD, it also increased from 5.1333 ± 1.89 to 7.0167 ± 1.03 (p=0.000). CBIA method is proven to be more effective in enhancing knowledge regarding DAGUSIBU compared to FGD method with p value = 0.007. In conclusion, there are significant differences in the knowledge of DAGUSIBU among the students of MA Nurul Ummah after receiving this education through active learning (CBIA) and FGD methods.