Pengaruh Pemberian Air Rebusan Mahkota Dewa (Phaleria Macrocarpa (Scheff) Boerl) Terhadap Kadar Asam Urat Darah Pada Wanita Menopause

S, Didien Ika; E, Erni Dwi; Kusmiwiyati, Ari

doi:10.25047/j-kes.v5i1.37

Cited by 3 publications

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“…Senyawa yang diduga memiliki aktivitas menurunkan kadar asam urat di dalam daun murbei adalah golongan senyawa flavonoid. Kemampuan senyawa flavonoid dalam menurunkan asam urat yaitu dengan mekanisme hambatan terhadap enzim xantin oksidase pada basa purin sehingga dapat menurunkan kadar asam urat (Ika, et al 2017).…”

Section: Hasil Dan Pembahasanunclassified

EFEKTIVITAS SIRUP EKSTRAK DAUN MURBEI (Morus alba L.) TERHADAP PENURUNAN ASAM URAT PADA MENCIT (Mus Musculus)

Kusuma

Febriani

Saragih

2020

J. Tumbuhan Obat Indonesia

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ABSTRACT Allopurinol is an isostatic uric acid drug. Long-term use of allopurinol may cause liver failure, hepatitis, diarrhea, constipation, nausea, vomiting, and eczema. Mulberry leaves extract at doses 250 (M250), 500 (M500), and 750 (M750) mg/kg of body weight known had effectiveness in decreasing uric acid levels in mice. This study aimed to know the physical stability and effectiveness of mulberry leaves extract syrup in reducing uric acid levels. Phytochemical screening was carried out to determine the class of compounds in the mulberry extract. The extract was then prepared into syrup formulation. Syrup preparations were examined for physical stability, included organoleptic, pH, homogeneity, and viscosity. The 24 mice, were induced hyperuricemia with fresh chicken liver. Mice were divided into 6 groups, i.e. mulberry leaves extract syrup M250, M500, M750, positive control allopurinol, negative control CMC Na, and control group. Blood uric acid levels were measured at 0, 60, and 90 minutes. The phytochemistry screening showed the extract contained alkaloid, flavonoid, saponin, tannin, and terpenoid. The organoleptic test of mulberry leaves extracts syrup was liquid, green, sweet, pH 4.2-4.5, and homogeneous. The mulberry leaves extract syrup M250, M500, M750 significantly decreased uric acid levels compared to solvent treatment, respectively 32+4,3, 55+5,6, and 41+3,7%, while the allopurinol 62+2,0%, p>0.05. The mulberry leaves extract can be formulated into syrup dosage form and has good physical stability. Keywords: uric acid, Morus alba, mulberry leaves syrup Allopurinol merupakan obat asam urat yang bersifat urikostatik. Penggunaan allopurinol jangka panjang dapat menyebabkan gagal hati, hepatitis, diare, konstipasi, mual, muntah dan eksim. Ekstrak daun murbei (M250), 500 (M500) dan 750 (M750) mg/kg BB diketahui dapat menurunkan kadar asam urat pada mencit. Penelitian ini bertujuan untuk mengetahui stabilitas fisik sirup ekstrak daun murbei dan efektifitasnya dalam menurunkan kadar asam urat. Penapisan fitokimia dilakukan untuk mengetahui kandungan golongan kimia dalam ekstrak daun murbei. Ekstrak diformulasi menjadi sediaan sirup dan dilakukan pengujian organoleptik, pH, homogenitas dan viskositasnya. Sejumlah 24 mencit diinduksi hiperurisemia dengan memberikan hati ayam segar. Mencit hiperurisemia kemudian dibagi menjadi 6 kelompok dengan perlakuan sirup ektrak daun M250, M500, M750, kontrol allopurinol dan Na CMC. Kadar asam urat darah diukur pada menit ke 0, 60 dan 90. Penapisan fitokimia menunjukkan ekstak daun murbei memiliki kandungan alkaloid, flavonoid, saponin, tanin dan terpenoid. Pengamatan organoleptik sirup ekstrak daun murbei berwujud cair, hijau, manis, pH4,2-4,5 dan bersifat homogen. Hasil penelitian menunjukkan sirup ekstrak daun murbei M250, M500, M750 menurunkan kadar asam urat secara signifikan dibandingkan perlakuan pelarut, berturut-turut sebesar 32+4,3, 55+5,6 dan 41+3,7%, sedangkan kelompok kontrol allopurinol 62+2,0%, p>0.05. Dengan demikian, ekstrak daun murbei dapat diformulasi menjadi sediaan sirup dengan stabilitas fisik yang baik. Kata kunci: Asam urat, Morus alba, sirup daun murbei

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Section: Hasil Dan Pembahasanunclassified

EFEKTIVITAS SIRUP EKSTRAK DAUN MURBEI (Morus alba L.) TERHADAP PENURUNAN ASAM URAT PADA MENCIT (Mus Musculus)

Kusuma

Febriani

Saragih

2020

J. Tumbuhan Obat Indonesia

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Hemoglobin Level and Total Differential Blood Leucocytes of Broiler Chicken Given Different Probiotics

Badaruddin

Hafid

Nafiu

et al. 2022

IJSRSET

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The use of adding probiotics to drinking water is an alternative to reduce the accumulation of additional chemical feed residues in meat, which functions to maintain the balance of the microflora ecosystem in the digestive tract and provide enzymes that can digest crude fiber, protein, fat and detoxify toxic substances or metabolites. This study aimed to determine the hemoglobin level and total differential leukocyte blood of broiler chickens given different probiotics using 100 broiler strains of MB 202 platinum with 20 cages with a size of 80X80 cm. The research design used a completely randomized design (CRD) with 4 treatments and 5 replications consisting of 5 chickens for each replication. The results showed that blood hemoglobin levels had a significant effect (P>0.05) and the administration of different probiotics into drinking water had no significant effect (P>0.05) on the differential value of leukocytes (monocytes, eosinophils, heterophils, and basophils) in broiler blood, but giving different probiotics had a significant effect (P<0.05) on blood lymphocyte levels in broiler chickens.

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Effect of Fruit Decoction of Phaleria Macrocarpa on Uric Acid Levels in Elderly

Simanullang¹

2018

Belitung Nurs J

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Background: The incidence of gout is rising both in the developed and developing countries not only in the elderly but also in young adults. Thus, the effort to reduce its incidence is necessary.Objective: To determine the effect of fruit decoction of phaleria macrocarpha on the levels of uric acid in the elderly.Methods: This was a pre-experimental study with pretest and posttetst design. This study was conducted at Sei Semayang Village North Sumatra from April to May 2017. There were 10 elderly selected using purposive sampling. Urid acid levels were measured using monitoring system of Easy Touch GCU. Independent t-test were used for data analysis.Results: Findings of this study showed that there was a significant difference in the mean value of the levels of uric acid before and after given fruit decoction of phaleria macrocarpa (p=0.004).Conclusion: There was a significant effect of fruit decoction of phaleria macrocarpa to decrease the level of uric acid in elderly. It is suggested that fruit decoctions of phaleria macrocarpa can be one of alternative therapies to prevent the increase of uric acid.

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Pengaruh Pemberian Air Rebusan Mahkota Dewa (Phaleria Macrocarpa (Scheff) Boerl) Terhadap Kadar Asam Urat Darah Pada Wanita Menopause

Cited by 3 publications

References 0 publications

EFEKTIVITAS SIRUP EKSTRAK DAUN MURBEI (Morus alba L.) TERHADAP PENURUNAN ASAM URAT PADA MENCIT (Mus Musculus)

EFEKTIVITAS SIRUP EKSTRAK DAUN MURBEI (Morus alba L.) TERHADAP PENURUNAN ASAM URAT PADA MENCIT (Mus Musculus)

Hemoglobin Level and Total Differential Blood Leucocytes of Broiler Chicken Given Different Probiotics

Effect of Fruit Decoction of Phaleria Macrocarpa on Uric Acid Levels in Elderly

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