Pharmacokinetics and tissue residues of hydrochloric acid albendazole sulfoxide and its metabolites in crucian carp (Carassius auratus) after oral administration

Li, Zaijian; Chen, Cuilan; Ai, Diyun; Wang, Chunmei; Li, Jing; Qi, Yuanhua; Yi, Wei-Xue; Shen, Hongchun; Cao, Jiyue

doi:10.1016/j.etap.2011.12.001

Cited by 14 publications

(14 citation statements)

References 15 publications

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“…Temperature plays an important role in the absorption rate of moroxydine hydrochloride (Li et al ., ). In this study, moroxydine hydrochloride was investigated in gibel carp after oral administration at two different temperatures.…”

Section: Discussionsupporting

confidence: 94%

“…This observation was further supported by the actual data obtained from the plasma and tissue pharmacokinetics study where the concentrations of moroxydine hydrochloride were detected more slowly at 15 °C than at 25 °C. Similar trends were observed with hydrochloric acid albendazole sulfoxide in crucian carp at different temperatures after oral administration (Li et al ., ). The k a of moroxydine hydrochloride was 4.29/h at 15 °C and 2.02/h at 25 °C.…”

Section: Discussionmentioning

confidence: 97%

“…The results indicated that the method was adaptable and gave good reproducibility and sensitivity that could be applied to investigations of pharmacokinetics and residue depletion in the gibel carp. Temperature plays an important role in the absorption rate of moroxydine hydrochloride (Li et al, 2012). In this study, moroxydine hydrochloride was investigated in gibel carp after oral administration at two different temperatures.…”

Section: Discussionmentioning

confidence: 99%

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Pharmacokinetics and tissue residues of moroxydine hydrochloride in gibel carp, Carassius gibelio after oral administration

Liu

Zhou

et al. 2016

Vet Pharm & Therapeutics

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The pharmacokinetics and tissue residues of moroxydine hydrochloride were studied in gibel carp at water temperature of 15 and 25 °C. Samples (blood, skin, muscle, liver, and kidney) were collected over 10 days after the treatment and analyzed by high-performance liquid chromatography with an ultraviolet detector. The results indicated that the influence of water temperature on the metabolism of the drug was significant. The plasma concentration-time data of moroxydine hydrochloride conformed to single-compartment open model at the two water temperatures. There were higher absorption rate (t1/2ka ) and longer elimination half-lives (t1/2ke ) at 15 °C (4.29 and 15.87 h, respectively) compared with those at 25 °C (3.02 and 4.22 h, respectively). The maximum plasma concentration (Cmax ) and the time-point of maximum plasma concentration (Tp ) were 2.98 μg/mL and 10.35 h at 15 °C and 3.12 μg/mL and 4.03 h at 25 °C, respectively. The distribution volume (Vd /F) of moroxydine hydrochloride was estimated to be 4.55 L/kg at 15 °C and 2.89 L/kg at 25 °C. The total body clearance (CLb ) of moroxydine hydrochloride was determined to be 0.25 and 0.49 L/(h·kg) at 15 °C and 25 °C, respectively; the areas under the concentration-time curve were 75.89 μg·h/mL at 15 °C and 42.33 μg·h/mL at 25 °C. The depletion of moroxydine hydrochloride in gibel carp was slower with a longer half-life period, especially at lower water temperature that was tested.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Pharmacokinetics and tissue residues of moroxydine hydrochloride in gibel carp, Carassius gibelio after oral administration

Liu

Zhou

et al. 2016

Vet Pharm & Therapeutics

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“…The ABZSX metabolites gradually increased, V / f (c) and CL(s) decreased, and AUC, t max , and T 1/2 increased compared with those of the ABZ suspension. In addition, the clear increase in the MRT indicates that the cycling time, bioavailability, and curative effect of the drug from the NPs on the hydatid cyst membrane significantly improved 38…”

Section: Discussionmentioning

confidence: 99%

Novel albendazole–chitosan nanoparticles for intestinal absorption enhancement and hepatic targeting improvement in rats

et al. 2013

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To improve the treatment of helminthiasis, filariasis, and colorectal cancer, albendazole-associated chitosan nanoparticles (ABZ-CS-NPs) were prepared using the emulsion crosslinking volatile technique with contained sodium tripolyphosphate as the crosslinking agent and Poloxamer 188 as the auxiliary solvent. The structural characteristics of the NPs were determined using X-ray diffraction to analyze the interaction between CS and the drug. The NPs were then evaluated in terms of their physicochemical characteristics, drug release behavior, in vivo pharmacokinetic parameters, and biodistribution in animal studies. ABZ-loaded NPs with a uniformly spherical particle sizes (157.8 ± 2.82 nm) showed efficient drug loading, encapsulated efficiency, and high physical stability. The drug release from ABZ-CS-NPs was extended over several periods. Kinetic models were then fitted to determine the release mechanisms. ABZ and its metabolite albendazole sulfoxide (ABZSX) were analyzed in rats with mebendazole as the internal standard using reversed-phase high-performance liquid chromatography. Compared with the ABZ suspension groups, the relative bioavailability values of ABZ and ABZSX were 146.05 and 222.15%, respectively. In addition, the plasma concentration versus time curve is consistent with that of the two compartment models in the plasma concentration versus time curve. The results indicate that the ABZ-loaded NPs are promising novel ABZ candidates for passive diffusion in the treatment of hydatid cysts in the liver via oral administration.

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“…Blunt-snout bream (Megalobrama amblycephala), an herbivorous freshwater carp, is widely distributed worldwide and is important to China's economy (Li, Jiang, Jiang, Liu, & Ge, 2012;Li, Chen, et al, 2012). With the increasing scale of cultivation and centralization, disease outbreaks occur frequently and lead to severe economic losses (Xiong et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of florfenicol in blunt‐snout bream (Megalobrama amblycephala) at two water temperatures with single‐dose oral administration

Huang

Chen

Wang

et al. 2019

Vet Pharm & Therapeutics

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The pharmacokinetics and residue elimination of florfenicol (FFC) and its metabolite florfenicol amine (FFA) were studied in healthy blunt‐snout bream (Megalobrama amblycephala, 50 ± 10 g). The study was conducted with a single‐dose (25 mg/kg) oral administration at a water temperature of 18 or 28°C, while in the residue elimination study, fish were administered at 25 mg/kg daily for three consecutive days by oral gavage to determine the withdrawal period (WDT) at 28°C. The FFC and FFA levels in plasma and tissues (liver, kidneys and muscle) were analysed using high‐performance liquid chromatography (HPLC). A no‐compartment model was used to analyse the concentration versus time data of M. amblycephala. In the two groups at 18 and 28°C, the maximum plasma concentration (Cmax) of FFC was 5.89 and 6.21 μg/ml, while the time to reach Cmax (Tmax) was 5.97 and 2.84 hr, respectively. These suggested that higher temperature absorbed more drug and more quickly at M. amblycephala. And the elimination half‐life (T1/2kβ) of FFC was calculated as 26.75 and 16.14 hr, while the total body clearance (CL) was 0.09 and 0.15 L kg−1 hr−1, and the areas under the concentration–time curves (AUCs) were 265.87 and 163.31 μg hr/ml, respectively. The difference demonstrated that the elimination rate of FFC in M. amblycephala at 28°C was more quickly than that at 18°C. The results of FFA showed the same trend in tissues of M. amblycephala. After multiple oral doses (25 mg/kg daily for 3 days), the k (eliminate rate constant) of FFA in M. amblycephala muscle was 0.017, the C0 (initial concentration) was 3.07 mg/kg, and the WDT was 10 days (water temperature 28°C).

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Pharmacokinetics and tissue residues of hydrochloric acid albendazole sulfoxide and its metabolites in crucian carp (Carassius auratus) after oral administration

Cited by 14 publications

References 15 publications

Pharmacokinetics and tissue residues of moroxydine hydrochloride in gibel carp, Carassius gibelio after oral administration

Pharmacokinetics and tissue residues of moroxydine hydrochloride in gibel carp, Carassius gibelio after oral administration

Novel albendazole–chitosan nanoparticles for intestinal absorption enhancement and hepatic targeting improvement in rats

Pharmacokinetics of florfenicol in blunt‐snout bream (Megalobrama amblycephala) at two water temperatures with single‐dose oral administration

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