Pharmacological research progress of ursolic acid for the treatment of liver diseases

Yu, Liang; Niu, QianQian; Zhao, YuanHong

doi:10.53388/tmr20210331227

Cited by 4 publications

(3 citation statements)

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“…Apoptosis is known to contribute to various cardiovascular diseases, including heart failure, myocardial infarct, and reperfusion injury [ 35 , 36 ]. Previous research has also shown that cardiac hypertrophy is related to a reduced cell number due to enhanced apoptosis [ 37 , 38 ]. In addition, oxidative stress has been shown to be responsible for cardiomyocyte apoptosis [ 39 – 41 ].…”

Section: Discussionmentioning

confidence: 99%

Peroxiredoxin-5 Knockdown Accelerates Pressure Overload-Induced Cardiac Hypertrophy in Mice

Dai

Wang

et al. 2022

Oxidative Medicine and Cellular Longevity

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A recent study showed that peroxiredoxins (Prxs) play an important role in the development of pathological cardiac hypertrophy. However, the involvement of Prx5 in cardiac hypertrophy remains unclear. Therefore, this study is aimed at investigating the role and mechanisms of Prx5 in pathological cardiac hypertrophy and dysfunction. Transverse aortic constriction (TAC) surgery was performed to establish a pressure overload-induced cardiac hypertrophy model. In this study, we found that Prx5 expression was upregulated in hypertrophic hearts and cardiomyocytes. In addition, Prx5 knockdown accelerated pressure overload-induced cardiac hypertrophy and dysfunction in mice by activating oxidative stress and cardiomyocyte apoptosis. Importantly, heart deterioration caused by Prx5 knockdown was related to mitogen-activated protein kinase (MAPK) pathway activation. These findings suggest that Prx5 could be a novel target for treating cardiac hypertrophy and heart failure.

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Section: Discussionmentioning

confidence: 99%

Peroxiredoxin-5 Knockdown Accelerates Pressure Overload-Induced Cardiac Hypertrophy in Mice

Dai

Wang

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…CPa inhibited LX-2 cell multiplication, activation, ECM production, and TGFβ/Smads signaling pathway LX-2 cells were pretreated with both LPS (100 ng mL −1 ) and CPa (10,30,60,120, and 240 μg mL −1 ) to evaluate the effect of CPa on the proliferation of HSCs. The results indicated that as the CPa concentration increases, the ability to inhibit LX-2 cells gradually increases (Fig.…”

Section: Food and Function Papermentioning

confidence: 99%

“…Hepatic fibrosis is the multiple pathogenic factors-induced pathological status of long-term chronic hepatic injury, and it is characterized by extensive deposition of extracellular matrix (ECM) and abnormal proliferation of specific fibroblasts, and end-stage fibrosis can progress to cirrhosis or even hepatocellular carcinoma. 9,10 As eating habits change, the incidence of hepatic fibrosis is increasing year by year. The World Health Organization has reported that chronic liver disease-induced liver fibrosis accounts for 2% of global deaths.…”

Section: Introductionmentioning

confidence: 99%

Coprinus comatuspolysaccharides ameliorated carbon tetrachloride-induced liver fibrosis through modulating inflammation and apoptosis

Zhao

et al. 2022

Food Funct.

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Ursolic acid: a natural modulator of signaling networks in different cancers

et al. 2022

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Incidence rate of cancer is estimated to increase by 40% in 2030. Furthermore, the development of resistance against currently available treatment strategies has contributed to the cancer-associated mortality. Scientists are now looking for the solutions that could help prevent the disease occurrence and could provide a pain-free treatment alternative for cancers. Therefore, efforts are now put to find a potent natural compound that could sever this purpose. Ursolic acid (UA), a triterpene acid, has potential to inhibit the tumor progression and induce sensitization to conventional treatment drugs has been documented. Though, UA is a hydrophobic compound therefore it is usually chemically modified to increase its bioavailability prior to administration. However, a thorough literature indicating its mechanism of action and limitations for its use at clinical level was not reviewed. Therefore, the current study was designed to highlight the potential mechanism of UA, its anti-cancer properties, and potential applications as therapeutic compound. This endeavour is a valuable contribution in understanding the hurdles preventing the translation of its potential at clinical level and provides foundations to design new studies that could help enhance its bioavailability and anti-cancer potential for various cancers.

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Pharmacological research progress of ursolic acid for the treatment of liver diseases

Cited by 4 publications

References 0 publications

Peroxiredoxin-5 Knockdown Accelerates Pressure Overload-Induced Cardiac Hypertrophy in Mice

Peroxiredoxin-5 Knockdown Accelerates Pressure Overload-Induced Cardiac Hypertrophy in Mice

Coprinus comatuspolysaccharides ameliorated carbon tetrachloride-induced liver fibrosis through modulating inflammation and apoptosis

Ursolic acid: a natural modulator of signaling networks in different cancers

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