Plasma leptin levels and free leptin index in women with Alzheimer's disease

Baranowska-Bik, Agnieszka; Bik, Wojciech; Styczyńska, Maria; Chodakowska-Żebrowska, Małgorzata; Barcikowska, Maria; Woliñska-Witort, Ewa; Kalisz, Małgorzata; Martyńska, Lidia; Baranowska, B

doi:10.1016/j.npep.2015.05.006

Cited by 42 publications

(32 citation statements)

References 44 publications

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“…The therapeutic implication of these observations augments by the previous data reported in EAE mice, when the in vivo neutralization of the hormone impacted the severity of the disease [48]. A link between leptin levels and Alzheimer's disease (AD) has been also postulated [49,50]. Leptin effects are example of the tight interactions between the endocrine, immune and neuronal systems affected all by dietary factors and that can in turn regulate dietary habits.…”

Section: Gut Microbiome and Obesitymentioning

confidence: 70%

The Second Brain: Is the Gut Microbiota a Link Between Obesity and Central Nervous System Disorders?

Ochoa‐Repáraz

Kasper

2016

Curr Obes Rep

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The gut-brain axis is a bi-directional integrated system composed by immune, endocrine and neuronal components by which the gap between the gut microbiota and the brain is significantly impacted. An increasing number of different gut microbial species are now postulated to regulate brain function in health and disease. The westernized diet is hypothesized to be the cause of the current obesity levels in many countries, a major socio-economical health problem. Experimental and epidemiological evidence suggest that the gut microbiota is responsible for significant immunologic, neuronal and endocrine changes that lead to obesity. We hypothesize that the gut microbiota, and changes associated with diet, affect the gut-brain axis and may possibly contribute to the development of mental illness. In this review, we discuss the links between diet, gut dysbiosis, obesity, and immunologic and neurologic diseases that impact brain function and behavior.

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Section: Gut Microbiome and Obesitymentioning

confidence: 70%

The Second Brain: Is the Gut Microbiota a Link Between Obesity and Central Nervous System Disorders?

Ochoa‐Repáraz

Kasper

2016

Curr Obes Rep

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“…The results of two large population based prospective studies provided the evidence for a lower incidence of AD in elderly individuals associated with higher leptin levels (Holden et al 2009; Lieb et al 2009). Several case–control studies showed that AD patients had significantly decreased plasma levels of leptin compared with healthy controls (Bigalke et al 2011; Baranowska-Bik et al 2015). …”

Section: Discussionmentioning

confidence: 99%

“…(Parimisetty et al 2016). Several case–control and large population based prospective studies have shown an association of lower circulating leptin levels with AD or general cognitive decline (Lieb et al 2009; Baranowska-Bik et al 2015), but some clinical studies found no differences in AD and controls (Theodoropoulou et al 2012; Warren et al 2012; Teunissen et al 2015). In case of adiponectin the epidemiological link with AD risk is less clear.…”

Section: Introductionmentioning

confidence: 99%

Association of adiponectin, leptin and resistin with inflammatory markers and obesity in dementia

et al. 2017

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The aim of the study was to determine the role of adiponectin, leptin and resistin in various types of dementia and to investigate their association with inflammatory markers, insulin resistance and abdominal obesity. In 205 patients with dementia [89 with Alzheimer’s disease (AD), 47 with vascular dementia (VaD), 69 with mixed dementia (MD)], 113 persons with mild cognitive impairment and in 107 controls serum adiponectin, leptin and resistin levels, pro-inflammatory [interleukin-6 (IL-6), C-reactive protein (hsCRP) and chitotriosidase] and anti-inflammatory (25-OH vitamin D, HDL-cholesterol and paraoxonase 1) markers, as well as glucose metabolism parameters (glucose, insulin and HOMA-IR) were determined. In all-cause dementia adiponectin and resistin levels were significantly higher as compared to the controls; leptin levels did not show differences. Higher adiponectin levels concerned AD and MD, whereas higher resistin-VaD and MD. After stratification by abdominal obesity the differences in adiponectin levels remained significant in subjects without obesity. In all-cause dementia negative correlation of adiponectin with obesity, glucose metabolism parameters, IL-6 and hsCRP and positive correlation with HDL-cholesterol were found. Positive correlation of resistin with age, IL-6, hsCRP and chitotriosidase and negative correlation with HDL-cholesterol and paraoxonase 1 were stated. We conclude that dementia of neurodegenerative origin is characterized by elevated adiponectin levels, whereas dementia with vascular changes by increase of resistin. Association with inflammatory indicators may suggest the pro-inflammatory role of resistin in the development of dementia, especially in dementia of vascular mechanism. Identification of this novel biomarker may be important in preventing dementia.

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“…With notable exceptions [86,87], most epidemiological studies also support the notion that leptin may be protective in dementia, since low plasma leptin levels in late-life are associated with worsening cognitive decline and increased dementia risk in longitudinal studies [88,89]. Furthermore, in cross-sectional studies plasma leptin levels were found to be lower in AD subjects compared to normal controls independent of body weight/adiposity [90–92]. Experimental studies also implicated leptin in AD pathology.…”

Section: Leptin: Cerebrovascular Disease and Dementiamentioning

confidence: 99%

Adipocyte-derived factors in age-related dementia and their contribution to vascular and Alzheimer pathology

Ishii

Iadecola

2016

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Age-related dementia is increasingly recognized as having a mixed pathology, with contributions from both cerebrovascular factors and pathogenic factors associated with Alzheimer’s disease (AD). Furthermore, there is accumulating evidence that vascular risk factors in midlife, e.g., obesity, diabetes, and hypertension, increase the risk of developing late-life dementia. Since obesity and changes in body weight/adiposity often drive diabetes and hypertension, understanding the relationship between adiposity and age-related dementia may reveal common underlying mechanisms. Here we offer a brief appraisal of how changes in body weight and adiposity are related to both AD and dementia on vascular basis, and examine the involvement of two key adipocyte-derived hormones: leptin and adiponectin. The evidence suggests that in midlife increased body weight/adiposity and subsequent changes in adipocyte-derived hormones may increase the long-term susceptibility to dementia. On the other hand, later in life, decreases in body weight/adiposity and related hormonal changes are early manifestations of disease that precede the onset of dementia and may promote AD and vascular pathology. Understanding the contribution of adiposity to age-related dementia may help identify the underlying pathological mechanisms common to both vascular dementia and AD, and provide new putative targets for early diagnosis and therapy.

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Plasma leptin levels and free leptin index in women with Alzheimer's disease

Cited by 42 publications

References 44 publications

The Second Brain: Is the Gut Microbiota a Link Between Obesity and Central Nervous System Disorders?

The Second Brain: Is the Gut Microbiota a Link Between Obesity and Central Nervous System Disorders?

Association of adiponectin, leptin and resistin with inflammatory markers and obesity in dementia

Adipocyte-derived factors in age-related dementia and their contribution to vascular and Alzheimer pathology

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