Podophyllotoxin and other aryltetralin lignans from<i>Eriope latifolia</i>and<i>Eriope blanchetii</i>

Santos, Edlene O. dos; Lima, Luciano da Silva; David, Jorge M.; Martins, Lidiane C; Guédès, Michel; David, Juceni P.

doi:10.1080/14786410902809500

Cited by 9 publications

(7 citation statements)

References 14 publications

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“…To date, there are few chemical studies involving this species. Triterpenes and bioactive lignans have been isolated from its organic extracts [8,9]. …”

Section: Introductionmentioning

confidence: 99%

Bioactive Oleanane, Lupane and Ursane Triterpene Acid Derivatives

et al. 2012

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Betulinic, ursolic and oleanolic acids isolated from the aerial parts of Eriope blanchetii (Lamiaceae) were subjected to different esterification reactions, yielding 12 C-3 position ester derivatives. All compounds were identified using spectroscopic techniques, such as IR, 1H-NMR and MS. The derivatives were further investigated for their antioxidant level, Artemia salina lethality and antimicrobial activity.

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“…To date, there are few chemical studies involving this species. Triterpenes and bioactive lignans have been isolated from its organic extracts [8,9]. …”

Section: Introductionmentioning

confidence: 99%

Bioactive Oleanane, Lupane and Ursane Triterpene Acid Derivatives

et al. 2012

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“…The presence of aryltetralin lignans, including podophyllotoxin, as minor compounds in Eriope and Hyptis species (Fig. 1) has previously been reported (Novelo et al, 1993;Santos et al, 2011). Lamiaceae is comprised of 220 genera with approximately 4000 species occurring all over the world.…”

Section: Introductionmentioning

confidence: 75%

“…Podophyllotoxin standard were purchased (Sigma-Aldrich, USA) and yatein was previously isolated from Eriope blanchetii. The yatein purity was determined by HPLC and NMR (Santos et al, 2011).…”

Section: Hplc Analysis Of Lignansmentioning

confidence: 99%

Abiotic factors influencing podophyllotoxin and yatein overproduction in Leptohyptis macrostachys cultivated in vitro

Meira

David

Ribeiro

et al. 2017

Phytochemistry Letters

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This work describes an in vitro propagation protocol for the large-scale cultivation of Leptohyptis macrostachys (Benth.) Harley & JFB Pastore and the influence of abiotic factors on podophyllotoxin and yatein production. The plant was established from seeds collected in Chapada Diamantina, BA, Brazil and submitted to different growth mediums and physical conditions. The podophyllotoxin and yatein contents were quantified by HPLC/DAD and with pure standards and these two lignans were present in all experiments. The lignan quantities were evaluated using the Sisvar Program, compared by Tukey's test and hierarchical cluster analysis and principal component analysis. In all experiments, podophyllotoxin and yatein were detected at different concentrations. The best protocol cultivar of L. macrostachys was established from seeds in MS ½ medium supplemented with 1.5% sucrose and 11.55 μM of gibberellic acid A3 (GA 3 ) at 30°C, which yielded the highest concentration of podophyllotoxin (5.831 mg g −1 ). These results are important findings for the production of podophyllotoxin from the tissue culture.

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“…ex Benth.) Harley can accumulate oleanolic acid ( 75 ), ursolic acid ( 78 ) and epikatonic acid ( 113 ) ( Santos et al, 2011 ). Finally, the ethyl acetate fraction from Hypenia salzmannii afforded betulinic acid ( 74 ), oleanolic acid ( 75 ), ursolic acid ( 78 ) and sitosterol- β -D-glucoside ( 80 ) ( de Lucena et al, 2013 ).…”

Section: Phytochemistrymentioning

confidence: 99%

“…ex Benth. Further studies led to the identification of β -peltatin ( 115 ), yatein ( 120 ), podophyllotoxin ( 124 ) and α -peltatin ( 148 ) in the aerial parts of Eriope blanchetii ( David et al, 2001 ) and Eriope latifolia ( Santos et al, 2011 ).…”

Section: Phytochemistrymentioning

confidence: 99%

Subtribe Hyptidinae (Lamiaceae): A promising source of bioactive metabolites

Bridi

Meirelles

Poser

2021

Journal of Ethnopharmacology

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Ethnopharmacological relevance The subtribe Hyptidinae contains approximately 400 accepted species distributed in 19 genera ( Hyptis , Eriope , Condea , Cantinoa , Mesosphaerum , Cyanocephalus , Hypenia , Hyptidendron , Oocephalus , Medusantha , Gymneia , Marsypianthes , Leptohyptis , Martianthus , Asterohyptis , Eplingiella , Physominthe , Eriopidion and Rhaphiodon ). This is the Lamiaceae clade with the largest number of species in Brazil and high rates of endemism. Some species have been used in different parts of the world mainly as insecticides/pest repellents, wound healing and pain-relief agents, as well as for the treatment of respiratory and gastrointestinal disorders. Aim of the review This review aims to discuss the current status concerning the taxonomy, ethnobotanical uses, phytochemistry and biological properties of species which compose the subtribe Hyptidinae. Materials and methods The available information was collected from scientific databases (ScienceDirect, Pubmed, Web of Science, Scopus, Google Scholar, ChemSpider, SciFinder ACS Publications, Wiley Online Library), as well as other literature sources (e.g. books, theses). Results The phytochemical investigations of plants of this subtribe have led to the identification of almost 300 chemical constituents of different classes such as diterpenes, triterpenes, lignans, α -pyrones, flavonoids, phenolic acids and monoterpenes and sesquiterpenes, as components of essential oils. Extracts, essential oils and isolated compounds showed a series of biological activities such as insecticide/repellent, antimicrobial and antinociceptive, justifying some of the popular uses of the plants. In addition, a very relevant fact is that several species produce podophyllotoxin and related lignans. Conclusion Several species of Hyptidinae are used in folk medicine for treating many diseases but only a small fraction of the species has been explored and most of the traditional uses have not been validated by current investigations. In addition, the species of the subtribe appear to be very promising as alternative sources of podophyllotoxin-like lignans which are the lead compounds for the semi-synthesis of teniposide and etoposide, important antineoplastic agents. Thus, there is a wide-open door for future studies, both to support the popular uses of the plants and to find new biologically active compoun...

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Podophyllotoxin and other aryltetralin lignans fromEriope latifoliaandEriope blanchetii

Cited by 9 publications

References 14 publications

Bioactive Oleanane, Lupane and Ursane Triterpene Acid Derivatives

Bioactive Oleanane, Lupane and Ursane Triterpene Acid Derivatives

Abiotic factors influencing podophyllotoxin and yatein overproduction in Leptohyptis macrostachys cultivated in vitro

Subtribe Hyptidinae (Lamiaceae): A promising source of bioactive metabolites

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