Polyester nanomedicines targeting inflammatory signaling pathways for cancer therapy

Das, Sabya Sachi; Singh, Sandeep Kumar; Verma, Priya Ranjan Prasad; Gahtori, Rekha; Sibuh, Belay Zeleke; Kesari, Kavindra Kumar; Jha, Niraj Kumar; Dhanasekaran, Sugapriya; Thakur, Vijay Kumar; Wong, Ling Shing; Djearamane, Sinouvassane; Gupta, Piyush Kumar

doi:10.1016/j.biopha.2022.113654

Cited by 7 publications

(5 citation statements)

References 152 publications

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“…It was observed that the obtained emulsions showed a higher loading capacity than the suspension of SLNs based on trimyristin [95]. It was also observed that the absorption of CBD improved significantly compared with the medium-chain triglyceride (MCT) oil vehicle of CBD [96]. Several researchers investigated the effect of lipid type (medium-or long-chain triglycerides) combined with SNEDDS on the bioavailability of encapsulated CBD.…”

Section: Nanoemulsionsmentioning

confidence: 99%

“…Several researchers investigated the effect of lipid type (medium-or long-chain triglycerides) combined with SNEDDS on the bioavailability of encapsulated CBD. It was concluded that although the type of lipid affects the solubility, bioavailability, and physicochemical properties of CBD, after incorporation in nanoemulsion formulation, its effect on the bioavailability of CBD is not easily predicted and needs more in vivo investigations [96].…”

Section: Nanoemulsionsmentioning

confidence: 99%

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Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications

et al. 2023

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Cannabidiol (CBD), one of the most promising constituents isolated from Cannabis sativa, exhibits diverse pharmacological actions. However, the applications of CBD are restricted mainly due to its poor oral bioavailability. Therefore, researchers are focusing on the development of novel strategies for the effective delivery of CBD with improved oral bioavailability. In this context, researchers have designed nanocarriers to overcome limitations associated with CBD. The CBD-loaded nanocarriers assist in improving the therapeutic efficacy, targetability, and controlled biodistribution of CBD with negligible toxicity for treating various disease conditions. In this review, we have summarized and discussed various molecular targets, targeting mechanisms and types of nanocarrier-based delivery systems associated with CBD for the effective management of various disease conditions. This strategic information will help researchers in the establishment of novel nanotechnology interventions for targeting CBD.

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Section: Nanoemulsionsmentioning

confidence: 99%

Section: Nanoemulsionsmentioning

confidence: 99%

Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications

et al. 2023

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“…Then, the rationale for developing such metallopolymer nanocomposites stands due to the slower degradation profile, lesser bioavailability, and agglomeration behavior of metal/metal oxide nanoparticles. 9 By overcoming these physicochemical properties, metallopolymer nanocomposites have been used in drug delivery, 10 biosensing, bioimaging, bioelectronics, and environmental remediation applications. Concerns regarding toxicological impacts on the human health and the environment have arisen in response to the expanding usage of nanoparticles worldwide in recent years.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Toxicological Analysis of MnFe₂O₄@poly(tBGE-alt-PA) Composite as a Hybrid Nanomaterial for Possible Biomedical Use

Kumar

Bauri

Sahu

et al. 2023

ACS Appl. Bio Mater.

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Nanocomposites have significantly contributed to biomedical science due to less aggregation behavior and enhanced physicochemical properties. This study synthesized a MnFe2O4@poly(tBGE-alt-PA) nanocomposite for the first time and physicochemically characterized it. The obtained hybrid nanomaterial was tested in vivo for its toxicological properties before use in drug delivery, tissue engineering fields, and environmental applications. The composite was biocompatible with mouse fibroblast cells and hemocompatible with 2% RBC suspension. This nanocomposite was tested on Drosophila melanogaster due to its small size, well-sequenced genome, and low cost of testing. The larvae’s crawling speed and direction were measured after feeding. No abnormal path and altered crawling pattern indicated the nonappearance of abnormal neurological disorder in the larva. The gut organ toxicity was further analyzed using DAPI and DCFH-DA dye to examine the structural anomalies. No apoptosis and necrosis were observed in the gut of the fruit fly. Next, adult flies were examined for phenotypic anomalies after their pupal phases emerged. No defects in the phenotypes, including the eye, wings, abdomen, and bristles, were found in our study. Based on these observations, the MnFe2O4@poly(tBGE-alt-PA) composite may be used for various biomedical and environmental applications.

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“…Inflammation is a normal immune response to injury and infection; however, chronic inflammation can contribute to the development of various diseases. Due to its capacity to inhibit the production of pro-inflammatory cytokines, such as interleukin-1 beta (IL-1 β) and tumour necrosis factor-alpha (TNF-α), acetyl eugenol possesses anti-inflammatory properties [38]. It also has been discovered that acetyl eugenol has antimicrobial properties that make it effective against infections.…”

Section: Acetyl Eugenolmentioning

confidence: 99%

Unlocking the Full Potential of Clove (Syzygium aromaticum) Spice: An Overview of Extraction Techniques, Bioactivity, and Future Opportunities in the Food and Beverage Industry

et al. 2023

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This review article provides an overview of the bioactive compounds of clove, their health benefits, and their potential application in food and beverages. Cloves are rich in phenolic compounds, mainly eugenol, which exhibit antioxidant, anti-inflammatory, antimicrobial, antifungal, and wound-healing properties. Traditional methods of clove extraction, such as Soxhlet and maceration, have limitations. Green extraction methods, such as ultrasound-assisted extraction, pressurised liquid extraction, and microwave-assisted extraction, have shown promising results. The potential application of clove extract in various food and beverage products are also discussed. Finally, future perspectives and challenges for clove extraction are highlighted. Overall, the review highlights the potential of clove extract as a natural source of bioactive compounds for various applications in the food and beverage industry.

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Polyester nanomedicines targeting inflammatory signaling pathways for cancer therapy

Cited by 7 publications

References 152 publications

Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications

Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications

In Vivo Toxicological Analysis of MnFe₂O₄@poly(tBGE-alt-PA) Composite as a Hybrid Nanomaterial for Possible Biomedical Use

Unlocking the Full Potential of Clove (Syzygium aromaticum) Spice: An Overview of Extraction Techniques, Bioactivity, and Future Opportunities in the Food and Beverage Industry

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Polyester nanomedicines targeting inflammatory signaling pathways for cancer therapy

Cited by 7 publications

References 152 publications

Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications

Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications

In Vivo Toxicological Analysis of MnFe2O4@poly(tBGE-alt-PA) Composite as a Hybrid Nanomaterial for Possible Biomedical Use

Unlocking the Full Potential of Clove (Syzygium aromaticum) Spice: An Overview of Extraction Techniques, Bioactivity, and Future Opportunities in the Food and Beverage Industry

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Product

Resources

About

In Vivo Toxicological Analysis of MnFe₂O₄@poly(tBGE-alt-PA) Composite as a Hybrid Nanomaterial for Possible Biomedical Use