Preparation and characterization of hydrogels with potential for use as biomaterials

Abstract

Hydrogels have been extensively explored for biomedical applications due to their ability to absorb high water content in its structure, which gives excellent biocompatibility. This work aims at obtaining biocompatible hydrogels with potential for use in increasing the mechanical strength of bone substitutes, or controlled drug release. Poly (N-vinyl-2-pyrrolidone) hydrogels were prepared by free radical polymerization with and without the addition of acrylic acid. Azobisisobutyronitrile and ammonium persulfate were used as initiator and N,N-methylenebisacrylamide was used as the crosslinking agent. The characterization of the hydrogels was performed by thermogravimetric analysis, differential scanning calorimetry, infrared spectroscopy and swelling properties. The results obtained demonstrate different degrees of crosslinking and swelling of up to 490 ± 30%. The different properties of the hydrogels suggest different applications.

Methamidophos removal from aqueous solutions using a super adsorbent based on crosslinked poly(vinyl alcohol) hydrogel

“…The experimental data were consistent with literature reports that suggest that hydrogels require high concentrations (5–20 wt %) of crosslinker to produce a material with useful mechanical properties . Also, the in silico studies concluded that 20 wt % of crosslinker is optimum for obtaining a hydrogel with the best properties to remove MMP.…”

The Swelling Behaviors of poly(2-acrylamido-2-methyl-1-propane sulfonic acid co-1-vinyl-2-pyrrolidone) Hydrogels

“…It was reported that high concentration (5-20 wt.%) of cross-linker is required to obtain VP-based hydrogels with good mechanical strength [5]. Since concentration of VP is the lowest in AMPS90/VP10, mechanical property of this hydrogel is better than those of the AMPS80/VP20 and AMPS70/VP30 (see Fig.…”

“…2). Swelling capacity of hydrogels decreases with the increase of the cross-linking degree [5] since more cross-linked form of polymeric chains is produced [8]. It was observed that the equilibrium swelling value of P(AMPSco-VP) hydrogels both in deionized water (Fig.…”

“…2-acrylamido-2-methylpropanesulfonic acid (AMPS) based hydrogels show pH independent swelling attitude since ionic monomer AMPS has strongly ionizable sulfonate group and it dissociates wholly in the overall pH range [1,4]. 1-vinyl-2-pyrrolidone (VP) is a water soluble biocompatible monomer with nonionic nature [5]. However, homopolymer of VP (PVP) exhibits poor mechanical properties and low swelling capacity restricting the application of PVP hydrogels [4].…”

Insight Into the Current Directions in Functionalized Nanocomposite Hydrogels

“…The essential requirements for tissue engineering scaffolds are biocompatibility, biodegradability, having an interconnected porous structure, adequate mechanical properties, and appropriate surface chemistry. Since hydrogels have the potential to maintain a large water content, they are highly biocompatible (Thürmer et al, 2014). In addition, due to the hydrogel's inherent flexible and soft structure, they cause minimal harm when exposed to body tissue.…”